A5079233267- Proteoglycans and glycosaminoglycans research
- Blood Coagulation and Thrombosis Mechanisms
- Global Cancer Incidence and Screening
- Colorectal Cancer Surgical Treatments
- Glycosylation and Glycoproteins Research
- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Screening and Detection
- Genetic factors in colorectal cancer
- Protease and Inhibitor Mechanisms
- Platelet Disorders and Treatments
- Colorectal and Anal Carcinomas
- AI in cancer detection
- Gastric Cancer Management and Outcomes
- Carbohydrate Chemistry and Synthesis
- Venous Thromboembolism Diagnosis and Management
- Digital Radiography and Breast Imaging
- Cell Adhesion Molecules Research
- Blood properties and coagulation
- Angiogenesis and VEGF in Cancer
- Radiology practices and education
- Hemophilia Treatment and Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cancer Cells and Metastasis
- Pancreatic and Hepatic Oncology Research
- Atrial Fibrillation Management and Outcomes
Theological Seminary Bienenberg
2020-2024
Kantonsspital Baselland
2015-2024
Psychiatry Baselland
2016-2024
Radiology Associates of Albuquerque
2014-2023
University Hospital of Basel
2023
Royal Free London NHS Foundation Trust
2022
Royal London Hospital
2022
NeuroTrials Research (United States)
2021
University of Basel
2019
Sutter Health
2018-2019
A procedure is presented for purifying antithrombin-heparin cofactor from human plasma. The final product homogeneous as judged by disc gel electrophoresis, sodium dodecyl sulfate and immunoelectrophoresis. yield averages 12%. specific antibody directed against pure inhibitor preparations precipitates virtually all of both antithrombin heparin activity defibrinated purification, the immunoprecipitation, other data, indicate that activities are properties a single molecular species. thrombin...
Background: The relationships among breast density, age, and use of hormone replacement therapy (HRT) in cancer detection have not been fully evaluated. Objective: To determine how HRT individually combination affect the accuracy screening mammography. Design: Prospective cohort study. Setting: 7 population-based mammography registries North Carolina; New Mexico; Hampshire; Vermont; Colorado; Seattle, Washington; San Francisco, California. Participants: 329 495 women 40 to 89 years age who...
Using cultured cells from bovine and rat aortas, we have examined the possibility that endothelial might regulate growth of vascular smooth muscle cells. Conditioned medium confluent aortic inhibited proliferation growth-arrested exponential cells, or fibroblasts, did not inhibit cell growth. fibroblasts. In addition to apparent specificity both producer target cell, inhibitory activity was heat stable affected by proteases. It sensitive flavobacterium heparinase but hyaluronidase...
Tumor necrosis factor has been implicated in the activation of blood coagulation septicemia, a condition commonly associated with intravascular and disturbances hemostasis. To evaluate early dynamics route vivo coagulative response to tumor factor, we performed controlled study six healthy men, monitoring common intrinsic pathways highly sensitive specific radioimmunoassays.
BACKGROUND The blood coagulation system is activated in the acute phase of unstable angina and myocardial infarction. However, it remains unclear whether augmented function hemostatic mechanism serves only as a marker thrombotic episode or hypercoagulable state persists for prolonged period after clinical stabilization. METHODS AND RESULTS We prospectively measured plasma concentrations prothrombin fragment 1 + 2 (F1 2) fibrinopeptide A (FPA) consecutive patients presenting with (n = 81)...
With the large number of women having mammography-an estimated 28.4 million U.S. aged 40 years and older in 1998-the percentage cancers detected as ductal carcinoma situ (DCIS), which has an uncertain prognosis, increased. We pooled data from seven regional mammography registries to determine mammographically that are DCIS rate per 1000 mammograms.We analyzed on 653 833 mammograms 540 738 between 84 age who underwent screening at facilities participating National Cancer Institute's Breast...
Murine models of atherosclerosis, such as the apolipoprotein E (apoE) or LDL receptor knockout mice, usually do not exhibit many cardinal features human coronary heart disease (CHD), eg, spontaneous myocardial infarction, severe cardiac dysfunction, and premature death. Here we show that mice with homozygous null mutations in genes for both high density lipoprotein SR-BI apoE (SR-BI/apoE double [dKO] mice) morphological functional defects similarities to those seen CHD. When fed a standard...
Risk prediction models for breast cancer can be improved by the addition of recently identified risk factors, including density and use hormone therapy. We used prospective information to predict a diagnosis in cohort 1 million women undergoing screening mammography.There were 2,392,998 eligible mammograms from without previously diagnosed who had prior mammogram preceding 5 years. Within year mammogram, 11,638 with cancer. Separate logistic regression constructed premenopausal...
October 1997Breast Cancer Surveillance Consortium: a national mammography screening and outcomes database.Authors: R Ballard-Barbash, S H Taplin, B C Yankaskas, V L Ernster, D Rosenberg, P A Carney, W E Barlow, … Show All , M Geller, K Kerlikowske, Edwards, F Lynch, N Urban, Chrvala, Key, Poplack, J Worden, G Kessler FewerAuthor Info & AffiliationsVolume 169, Issue 4https://doi.org/10.2214/ajr.169.4.9308451 METRICS PDF
2-O -sulfated glucuronic acid; GlcNAc, N -acetylglucosamine; GlcN(Ac/S), -acetyl
Tumor necrosis factor (TNF) dramatically alters the levels of various surface components blood vessel wall, such as coagulation enzyme receptors, leukocyte-adhesive and class 1 major histocompatibility complex antigens, which may have relevance to its effects in septic shock, angiogenesis, tumor growth. However, precise mechanism by cytokine is able accomplish this remodeling endothelial cell has not been defined. We demonstrated that exposure bovine human cells TNF leads suppression...
Cloned bovine aortic endothelial cells were cultured with [35S]NazS04 and proteolyzed extensively papain.Radiolabeled heparan sulfate was isolated by DEAE-Sephacel chromatography.The mucopolysaccharide then affinity fractionated into two separate populations utilizing immobilized antithrombin.The sulfate, which bound tightly to the protease inhibitor, represented 0.84% of mass, accounted for >99% initial anticoagulant activity, exhibited a specific activity 1.16 USP units/106...
We studied in vitro the effects heparin on growth of rat aortic smooth muscle cells. Measurements were monitored by [3H]thymidine uptake and changes cell number over a period 3 days. Our results show that heparin-highly anticoagulant or nonanticoagulant-significantly inhibits also this is highly specfic interaction with regard to molecule type: i.e., other polyanions, except for low molecular weight dextran sulfate, do not have same effect growth, all cells are inhibited heparin; e.g.,...
We have examined the role of heparinlike molecules in regulation coagulation by perfusing rat hindquarters with purified human thrombin and its plasma inhibitor, antithrombin. Our data indicate that contact hemostatic components endothelium enhances rate thrombin-antithrombin complex formation as much 19-fold over uncatalyzed enzyme-inhibitor interaction. Heparinlike are responsible for antithrombin accelerating activity. The amount generated within hindlimb preparation after pretreatment...
Purpose: To retrospectively evaluate the range of performance outcomes radiologist in an audit screening mammography by using a representative sample U.S. radiologists to allow development benchmarks for mammography. Materials and Methods: Institutional review board approval was obtained, study HIPAA compliant. Informed consent or not obtained according institutional guidelines. Data from 188 mammographic facilities 807 between 1996 2002 were analyzed six registries Breast Cancer...
In most colorectal cancer (CRC) patients, outcome cannot be predicted because tumors with similar clinicopathological features can have differences in disease progression and treatment response. Therefore, a better understanding of the CRC biology is required to identify those patients who will benefit from chemotherapy find more tailored therapy plan for other patients. Based on unsupervised classification whole genome data 188 stages I–IV molecular was developed that consist at least three...