A5013411164- Pancreatic function and diabetes
- Birth, Development, and Health
- Diet, Metabolism, and Disease
- Natural Antidiabetic Agents Studies
- Diabetes and associated disorders
- Diet and metabolism studies
- Growth Hormone and Insulin-like Growth Factors
- Liver Disease Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Milk Quality and Mastitis in Dairy Cows
- Tuberculosis Research and Epidemiology
- Heart Failure Treatment and Management
- Metabolism, Diabetes, and Cancer
- Phytochemicals and Antioxidant Activities
- Diabetes Treatment and Management
- Gut microbiota and health
- Adipokines, Inflammation, and Metabolic Diseases
- Genomics and Phylogenetic Studies
- Congenital Anomalies and Fetal Surgery
- Parasitic infections in humans and animals
- Pancreatitis Pathology and Treatment
- Cardiovascular Function and Risk Factors
- Infant Nutrition and Health
- Diabetes Management and Research
- Microbial infections and disease research
Universidad Complutense de Madrid
2007-2024
Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas
2012-2024
Instituto de Salud Carlos III
2012-2024
Universidad Señor de Sipán
2024
Centro de Investigación Biomédica en Red
2023
Hospital Universitario Infanta Leonor
2023
Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition
2022
Hospital Universitario La Paz
2021
Hospital La Paz Institute for Health Research
2021
Universidad de Montevideo
2013
Scope Diabetes mellitus is associated with reductions in glutathione, supporting the critical role of oxidative stress its pathogenesis. Antioxidant food components such as flavonoids have a protective against stress‐induced degenerative and age‐related diseases. Flavonoids epicatechin ( EC ) constitute an important part human diet; they can be found green tea, grapes, cocoa possess multiple biological activities. This study investigates chemo‐protective effect induced by tert...
Because nonalcoholic steatohepatitis (NASH) is associated with impaired liver regeneration, we investigated the effects of G49, a dual glucagon‐like peptide‐1/glucagon receptor agonist, on NASH and hepatic regeneration. C57Bl/6 mice fed chow or methionine choline–deficient (MCD) diet for 1 week were divided into 4 groups: control (chow diet), MCD diet, plus M+G49 (MCD G49). Mice high‐fat (HFD) 10 weeks HFD H+G49 (HFD Following 2 groups) 3 treatment partial hepatectomy (PH) was performed, all...
We have recently shown that cocoa flavanols may anti‐diabetic potential by promoting survival and function of pancreatic beta‐cells in vitro. In this work, we investigated if a cocoa‐rich diet is able to preserve beta‐cell mass an animal model type 2 diabetes the mechanisms involved. Our results showed feeding during prediabetic state attenuates hyperglycaemia, reduces insulin resistant, increases beta cell obese Zucker diabetic rats. At molecular level, prevented apoptosis increasing levels...
Mice with deletion of insulin receptor substrate (IRS) 2 develop hyperglycaemia, impaired hepatic signaling and elevated gluconeogenesis. Protein tyrosine phosphatase 1B (PTP1B) inhibition by resveratrol improves peripheral sensitivity these mice. Although activates Sirtuin1 (Sirt1), the mechanisms underlying its beneficial effects are not totally elucidated. In this study, we have investigated whether Sirt1 mediates in controlling resistance diabetic mice.We attempted to ameliorate two...
Adipose tissue is a multifunctional organ that regulates many physiological processes such as energy homeostasis, nutrition, the regulation of insulin sensitivity, body temperature, and immune response. In this review, we highlight relevance different mediators control adipose activity through systematic review main players present in white brown tissues. Among them, inflammatory secreted by tissue, classical adipokines more recent ones, elements system infiltrated into (certain cell types...
La preparación docente constituye elemento indispensable para el desarrollo de conocimientos, habilidades y competencias en marco la profesión, Educación Física tiene como una sus mayores tareas estimular creatividad, experiencias, aprendizajes vivencias motrices mediante un diagnóstico fáctico, escuela primaria Jorge Matos del municipio 10 octubre conocer cómo los profesores enseñan regulación dirección movimientos estudiantes primer ciclo después periodo pos pandémico, se relevó que son...
The loss of functional beta-cell mass in diabetes is directly linked to the development diabetic complications. Although dietary flavonoids have demonstrated antidiabetic properties, their potential effects on pancreatic preservation and synergistic benefits with drugs remain underexplored. We developed a food enriched by combining cocoa powder carob flour (CCB), which has shown effects. Here, we investigated ability CCB, alone or combination metformin, preserve beta cells an established...
Fourteen strains of a hitherto unknown catalase-positive, aerobic, gram-positive coryneformlike organism were isolated from the milk sheep with subclinical mastitis different regions Spain. The phenotypically closely resembled one another and biochemically similar to Corynebacterium urealyticum afermentans subsp. lipophilum. results chemotaxonomic investigations consistent membership in genus Corynebacterium, comparative 16S rRNA gene sequencing studies showed that bacterium was indeed...
Four strains of a hitherto-unknown catalase-positive, facultatively anaerobic Corynebacterium species were isolated from the milk sheep affected by subclinical mastitis. The most characteristic phenotypic reactions four their weak fermentative acid production glucose, failure to produce mannitol, xylose, sucrose and maltose, strong CAMP reaction with Staphylococcus aureus. Chemotaxonomic investigations revealed presence cell wall based on mesodiaminopimelic short-chain mycotic acids, which...
MPOX (monkeypox) is a zoonotic viral disease, endemic in some Central and West African countries. However, May 2022, cases began to be reported non-endemic countries, demonstrating community transmission. Since the beginning of outbreak, different epidemiological clinical behaviors have been observed. We conducted an observational study at secondary hospital Madrid characterize suspected confirmed epidemiologically clinically. Besides general descriptive analysis, we compared data between...
Catch-up growth has been associated with the appearance of metabolic dysfunctions such as obesity and type 2 diabetes in adulthood. Because entero-insular axis is critical to glucose homeostasis control, we explored relevance incretins glucose-dependent insulinotropic polypeptide (GIP) glucagon-like peptide-1 (GLP-1) development these pathologies. Offspring rat dams fed ad libitum (control [C]) or 65% food-restricted during pregnancy suckling time (undernourished [U]) were weaned onto a...
ABSTRACT Type 2 diabetes mellitus is a complex metabolic disease and its pathogenesis involves abnormalities in both peripheral insulin action secretion. Previous vitro data showed that receptor isoform A, but not B, favours basal glucose uptake through specific association with endogenous GLUT1/2 murine hepatocytes beta cells. With this background, we hypothesized hepatic expression of A mouse model type could potentially increase the these cells, decreasing hyperglycaemia therefore...
We previously demonstrated that fetuses from undernourished pregnant rats exhibited increased β-cell mass and hyperinsulinemia, whereas keeping food restriction until adult age caused reduced mass, hypoinsulinemia, decreased insulin secretion. Because these alterations can be related to availability, we have now investigated early long-term effects of protein calorie on mRNA levels as well the possible mechanisms could modulate endogenous content. used at 21.5 days gestation proceeding...