A5013444788- Inflammatory mediators and NSAID effects
- Extracellular vesicles in disease
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer, Hypoxia, and Metabolism
- Fatty Acid Research and Health
- Eicosanoids and Hypertension Pharmacology
- Liver Disease and Transplantation
- Liver physiology and pathology
- Pulmonary Hypertension Research and Treatments
- Drug-Induced Hepatotoxicity and Protection
- Cancer, Lipids, and Metabolism
- Adipose Tissue and Metabolism
- MicroRNA in disease regulation
- Liver Disease Diagnosis and Treatment
- Cardiovascular Disease and Adiposity
- Mitochondrial Function and Pathology
- Cancer-related molecular mechanisms research
- Biochemical effects in animals
- ATP Synthase and ATPases Research
- Peroxisome Proliferator-Activated Receptors
- Cell Adhesion Molecules Research
- Genomics, phytochemicals, and oxidative stress
- Vector-borne infectious diseases
- Neuroendocrine regulation and behavior
- Circadian rhythm and melatonin
Universidad de Colima
2016-2025
Washington University in St. Louis
2024
Universidad Nacional Autónoma de México
2023
Autonomous University of Queretaro
2022
Consejo Nacional de Humanidades, Ciencias y Tecnologías
2019
Universidad Autónoma de Madrid
2013-2015
Instituto de Investigaciones Biomédicas Sols-Morreale
2013-2015
Consejo Superior de Investigaciones Científicas
2014
Instituto Politécnico Nacional
2009-2012
Center for Research and Advanced Studies of the National Polytechnic Institute
2009-2012
Because nonalcoholic steatohepatitis (NASH) is associated with impaired liver regeneration, we investigated the effects of G49, a dual glucagon‐like peptide‐1/glucagon receptor agonist, on NASH and hepatic regeneration. C57Bl/6 mice fed chow or methionine choline–deficient (MCD) diet for 1 week were divided into 4 groups: control (chow diet), MCD diet, plus M+G49 (MCD G49). Mice high‐fat (HFD) 10 weeks HFD H+G49 (HFD Following 2 groups) 3 treatment partial hepatectomy (PH) was performed, all...
ABSTRACT A hallmark of enteroaggregative Escherichia coli (EAEC) infection is a formation biofilm, which comprises mucus layer with immersed bacteria in the intestines patients. While studying mucinolytic activity Pic an vivo system, rat ileal loops, we surprisingly found that EAEC induced hypersecretion mucus, was accompanied by increase number mucus-containing goblet cells. Interestingly, isogenic pic mutant (EAEC Δ ) unable to cause this hypersecretion. Furthermore, purified also able...
Hepatocellular carcinoma (HCC) is the most common primary liver cancer, often diagnosed at advanced stages due to insufficient early screening and monitoring. MicroRNAs (miRNAs) are key regulators of gene expression potential biomarkers for cancer diagnosis. This study investigated diagnostic miRNAs in Extracellular Vesicles (EVs) from HCC. miRNA EVs was analyzed using HCC cell lines, circulating a Diethylnitrosamine (DEN)-induced tumor rat model, plasma samples patients. Receiver Operating...
Accumulation evidence links obesity-induced inflammation as an important contributor to the development of insulin resistance, which plays a key role in pathophysiology obesity-related diseases such type 2 diabetes and nonalcoholic fatty liver disease. Cyclooxygenase (COX)-1 -2 catalyze first step prostanoid biosynthesis. Because adult hepatocytes fail induce COX-2 expression regardless proinflammatory stimuli used, we have evaluated whether this lack under mild conditions might constitute...
Cyclooxygenase (COX) catalyzes the first step in prostanoid biosynthesis and exists as two isoforms. COX-1 is a constitutive enzyme involved physiological processes, whereas COX-2 induced by variety of stimuli. MicroRNAs (miRNAs) are noncoding RNAs that function key posttranscriptional regulators gene expression. Although it known expression regulated miRNAs, there no data regarding involvement miRNA regulation. Considering our previous results showing hepatocytes protects against insulin...
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, irreversible, and highly fatal disease. It characterized by the increased activation of both fibroblast myofibroblast that results in excessive extracellular matrix (ECM) deposition. Extracellular vesicles (EVs) have been described as key mediators intercellular communication various pathologies. However, role EVs development IPF remains poorly understood. This study aimed to characterize differentially expressed proteins...
Background: Transforming growth factor-β (TGF-β) plays a pivotal role in liver fibrosis, because it activates hepatic stellate cells, stimulating extracellular matrix deposition. Cyclooxygenase-2 (COX-2) has been associated with TGF-β its inhibition decreases expression and collagen production some cultured cell types. Aim: The aim of this work was to evaluate the ability celecoxib (a selective COX-2 inhibitor) prevent reverse fibrosis induced by CCl4. Methods: We established experimental...
Different studies in experimental diabetes models suggest that zinc oxide nanoparticles (ZnONPs) are useful as antidiabetic agents. However, this evidence was performed and measured long-term treatments with repeated doses of ZnONPs. This work aimed to evaluate the ZnONPs acute effects on glycemia during next six h after an oral or intraperitoneal administration treatment healthy diabetic rats. In study, streptozotocin-nicotinamide male Wistar rats were used a model. 10 mg/kg did not modify...
BackgroundType 2 diabetes (T2D) is a complex metabolic ailment marked by global high prevalence and significant attention in primary healthcare settings due to its elevated morbidity mortality rates. The pathophysiological mechanisms underlying the onset progression of this disease remain subjects ongoing investigation. Recent evidence underscores pivotal role intricate intercellular communication network, wherein cell-derived vesicles, commonly referred as extracellular vesicles (EVs),...
SUMMARY Six healthy adult mares were each given a single iv injection of trimethoprim ( tmp )-sulfamethoxazole smz ) at dosage 2.5 mg /kg body weight and 12.5 /kg. Serum concentrations drug measured serially over 24-hour period. For , the mean overall elimination rate constant (K) was 0.43/hr half-life (t 1/2 1.9 hours. The apparent volume distribution (at steady state) 1.62 L/kg clearance 886 ml/hr/kg. K 0.22/hr t 3.53 state 0.33 78.2 Each mare then 5 consecutive oral doses tmp-smz 12-hour...
Non-steroidal anti-inflammatory drugs (NSAIDs) are used primarily to treat inflammation, pain and fever. Their main mechanism of action is cyclooxygenase (COX) inhibition, this enzyme has been linked hepatotoxicity. The association COX liver injury been, in part, due the presence COX-2 isoform damaged possible induction by profibrotic molecules like Transforming Growth Factor-β (TGF-β). aim work was evaluate effects two most NSAIDs, acetyl salicylic acid (ASA) ibuprofen (IBP), on...
It has been demonstrated that this sulfasalazine (SF) inhibits the nuclear factor κB (NFκB) pathway, which regulates important genes during inflammation and immune answer. The aim of work was to evaluate effects SF on carbon tetrachloride (CCl 4 )-induced liver fibrosis. We formed following experimental groups rats: controls, damage induced by chronic CCl (0.4 g/kg, intraperitoneally, three times a week for 8 weeks) administration + (100 mg/kg/day, postoperatively administration. determined...
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive lung disease. Lesions in the epithelium cause alterations microenvironment that promote fibroblast accumulation. Extracellular vesicles (EVs) transport proteins, lipids, and nucleic acids, such as microRNAs (miRNAs). The aim of this study was to characterize differentially expressed miRNAs cargo EVs obtained from LL97 LL29 cell lines isolated IPF lungs versus those derived CCD19 line healthy donors. We characterized by...
Abstract Non-alcoholic fatty liver disease (NAFLD) is associated with post-operative failure (PLF) and impaired regeneration. We investigated the effects of a glucagon-like peptide-1 (GLP-1) receptor agonist on NAFLD, PLF regeneration in mice fed chow diet or methionine/choline-deficient (MCD) high fat (HFD). Fc-GLP-1 decreased transaminases, reduced intrahepatic triglycerides (TG) improved MCD-induced dysfuction. Macrophage/Kupffer cell-related markers were also although increased...
Abstract Hepatocellular carcinoma (HCC) progression is associated with dysfunctional mitochondria and bioenergetics impairment. However, no data about the relationship between mitochondrial supercomplexes (hmwSC) formation ATP production rates in HCC are available. Our group has developed an adenosine derivative, IFC-305, which improves function, it been proposed as a therapeutic candidate for HCC. We aimed to determine role of IFC-305 on both structure sequential cirrhosis-HCC model rats....
SUMMARY Six foals from 6 to 8 weeks of age were given a single oral dose rifampin at dosage 10 mg/kg body weight. Serum concentrations measured serially during 24-hour period. The mean peak serum concentration was 6.7 μg/ml 4 hours after treatment. decreased slowly, and 24 the value 2.7 μg/ml. elimination half-life 17.5 hours, rate constant 0.04/hr.
Idiopathic pulmonary fibrosis (IPF) is the most frequent and severe idiopathic interstitial pneumonia. It a chronic progressive disease with poor prognosis major cause of morbidity mortality. This has no cure; therefore, there clinical need to search for alternative treatments greater efficacy. In this study, we aimed evaluate effect extracellular vesicles (EVs) from Zingiber officinale (EVZO) in murine model bleomycin (BLM)-induced IPF administered through an osmotic minipump. EVZO had...
In B. bigemina, the 45 kilodaltons glycoprotein (GP-45) is most studied. GP-45 exposed on surface of bigemina merozoite, it believed to play a role in invasion erythrocytes, and characterized by high genetic antigenic polymorphism. The objective this study was determine if contains conserved B-cell epitopes, they would induce neutralizing antibodies. comparative analysis nucleotide amino acids sequences revealed percentage similarity between field isolates. Antibodies against peptides...