A5037424438- Cannabis and Cannabinoid Research
- Neuroscience and Neuropharmacology Research
- Ion channel regulation and function
- Sleep and Wakefulness Research
- Circadian rhythm and melatonin
- Inflammatory Bowel Disease
- Neurotransmitter Receptor Influence on Behavior
- Photoreceptor and optogenetics research
- Eosinophilic Esophagitis
- Microscopic Colitis
- Natural Antidiabetic Agents Studies
- Cardiac Ischemia and Reperfusion
- Biochemical effects in animals
- Forensic Toxicology and Drug Analysis
- Muscle Physiology and Disorders
- Adipose Tissue and Metabolism
- Neuroscience of respiration and sleep
- Nicotinic Acetylcholine Receptors Study
- Cardiac Fibrosis and Remodeling
- Cardiovascular Issues in Pregnancy
- Advanced Glycation End Products research
- Heart rate and cardiovascular health
- Diet, Metabolism, and Disease
- Magnesium in Health and Disease
- Curcumin's Biomedical Applications
Universidad de Colima
2013-2025
Bellvitge University Hospital
2022-2025
Howard Hughes Medical Institute
2010
Bose Institute
2010
University of California, Los Angeles
2008-2009
Abstract Background Patients with inflammatory bowel disease (IBD) carrying the HLA-DQA1*05 allele have a higher risk of developing immunogenicity and loss response to anti-TNFs. On other hand, this association has not been observed ustekinumab, fact that could help individualize treatment (J. Guardiola ECCO 2024). We do data for vedolizumab. Methods: Objective To evaluate relationship between HLA-QA1*05 persistence Methods Design: Unicentric retrospective cohort study from tertiary...
Hepatocellular carcinoma (HCC) is the most common primary liver cancer, often diagnosed at advanced stages due to insufficient early screening and monitoring. MicroRNAs (miRNAs) are key regulators of gene expression potential biomarkers for cancer diagnosis. This study investigated diagnostic miRNAs in Extracellular Vesicles (EVs) from HCC. miRNA EVs was analyzed using HCC cell lines, circulating a Diethylnitrosamine (DEN)-induced tumor rat model, plasma samples patients. Receiver Operating...
Forskolin is a diterpene derived from the plant Coleus forskohlii.Forskolin activates adenylate cyclase, which increases intracellular cAMP levels.The antioxidant and antiinflammatory action of forskolin due to inhibition macrophage activation with subsequent reduction in thromboxane B2 superoxide levels.These characteristics have made an effective medication for heart disease, hypertension, diabetes, asthma.Here, we evaluated effects chronic administration on blood glucose oxidative stress...
Large conductance voltage- and calcium-activated potassium channels (MaxiK, BK Ca ) are well known for sustaining cerebral coronary arterial tone their linkage to vasodilator β-adrenergic receptors. However, how MaxiK linked counterbalancing vasoconstrictor receptors is unknown. Here, we show that vasopressive thromboxane A2 (TP) can intimately couple with inhibit channels. Activation of the receptor its agonist trans -inhibits independently G-protein activation. This unconventional...
Different studies in experimental diabetes models suggest that zinc oxide nanoparticles (ZnONPs) are useful as antidiabetic agents. However, this evidence was performed and measured long-term treatments with repeated doses of ZnONPs. This work aimed to evaluate the ZnONPs acute effects on glycemia during next six h after an oral or intraperitoneal administration treatment healthy diabetic rats. In study, streptozotocin-nicotinamide male Wistar rats were used a model. 10 mg/kg did not modify...
To analyse the effect of chronic caffeine use on risk reduction and prognosis diabetes mellitus.In this 60-day study, five groups 11 healthy male Wistar rats were selected to receive one four doses (37.5, 56.2, 75.0 or 93.0 mg/kg per day) orally no (control). The glycaemia glucose tolerance was evaluated. After 15 days, each group treated with 60 streptozotocine induce mellitus, assessed for a further 45 days.In nondiabetic rats, had blood glucose. Compared controls, fasting levels declined...
The aim of this work was to determine whether Capsaicin may exert a vascular regulation through the activation CB1 and/or CB2 receptors causing vasorelaxation in rat aorta. Our results show location TRPV1 mainly endothelial and smooth muscle cells membrane. Nevertheless, caused artery mechanism independent TRPV1, since specific antagonists Capsazepine SB-366791 did not block effect Capsaicin. Because significant expression has been previously reported aorta, we used for these two prior...
This study aimed to investigate the function of cannabinoid receptor in neuromuscular junction frog (<i>Rana pipiens</i>). Miniature end-plate potentials were recorded using intracellular electrode recording technique cutaneous pectoris muscle presence agonists WIN55212-2 (WIN; <i>R</i>-(+)-[2,3-dihydro-5-methyl-3-[(morpholinyl)]-pyrolol[1,2,3<i>de</i>]-1,4-benzoxazinyl]-(1-naphthalenyl)methanone) and arachidonylcyclopropylamide [ACPA;...
The pathologic cardiac remodeling has been widely documented; however, the physiological induced by pregnancy and its reversion in postpartum are poorly understood. In present study we investigated changes collagen I (Col I) III III) mRNA protein levels left ventricle from rat heart during postpartum. Col expression samples were analyzed using quantitative PCR. Data obtained gene show that upregulated with contrast to expression, evaluated western blot showed is downregulated pregnancy....
Iron overload (IOL) increases the risk of diabetes mellitus (DM). Capsaicin (CAP), an agonist transient receptor potential vanilloid-1 (TRPV1), reduces effects IOL. We evaluated chronic CAP administration on hepcidin expression, kidney iron deposits, and urinary biomarkers in a male Wistar rat model with IOL DM (DM-IOL). was induced oral for 12 weeks streptozotocin. Four groups were studied: Healthy, DM, DM-IOL, DM-IOL + (1 mg·kg−1·day−1 weeks). deposits visualized Perls tissue staining...
Abstract Circadian rhythms synchronize to light through the retinohypothalamic tract (RHT), which is a bundle of axons coming from melanopsin retinal ganglion cells, whose synaptic terminals release glutamate ventral suprachiasmatic nucleus (SCN). Activation AMPA–kainate and NMDA postsynaptic receptors elicits increase in intracellular calcium required for triggering signaling cascade that ends phase shifts. During aging, there decline synchronization circadian light. With...
The effect of cannabinoids on caffeine contractures was investigated in slow and fast skeletal muscle fibers using isometric tension recording. In fibers, WIN 55,212-2 (10 5 μM) caused a decrease tension. These doses reduced maximum to 67.43 ± 8.07% (P = 0.02, n 5) 79.4 14.11% 0.007, compared control, respectively. Tension-time integral 58.37 7.17% 75.10 3.60% 0.002, 5), Using the CB1 cannabinoid receptor agonist ACPA (1 by 68.70 11.63% 0.01, 5); tension-time 66.82 6.89% controls. When...
In contrast to fast-twitch skeletal muscle fibers of the chicken, slow-twitch are fatigue-resistant. fast fibers, fatigue process has been related K(ATP) channels. present study, we investigated action glibenclamide (an anti-diabetic sulphonylurea that acts on channels) fatigued slow muscle, studying twitch and tetanus tension after inducing by continuous electrical stimulation. Our results showed (150 μM) increased post-fatigue about 25% with respect condition (P < 0.05). addition, tetanic...
Background and objectives: Cardiac remodeling in pregnancy postpartum is poorly understood. The aim of this study was to evaluate changes cardiac fibrosis (pericardial, perivascular, interstitial), as well the expression matrix metalloproteinases (MMP-1, MMP-2, MMP-9) their inhibitors (Tissue metalloproteinases, TIMP-1 TIMP-4) during late rat left ventricle. Materials Methods: Female Sprague-Dawley rats were used for study. Rats divided three groups: non-pregnant, pregnancy, postpartum....
The suprachiasmatic nucleus (SCN) is the main brain clock that regulates circadian rhythms in mammals. SCN synchronizes to LD cycle through retinohypothalamic tract (RHT), which projects ventral neurons via glutamatergic synapses. Released glutamate activates N-methyl-D-aspartate (NMDA) receptors, play a critical role activation of signaling cascades enable phase shifts. Previous evidence indicates presynaptic changes during postnatal development consist an increase RHT fibers impinging on...
Pharmacological synergism is a current strategy for the treatment of pain. However, few studies have been explored to provide evidence possible between non-steroidal anti-inflammatory drug (NSAID) and cannabinoid agonist, in order establish which combinations might be effective manage The aim this study was explore ibuprofen (IBU) synthetic WIN 55,212-2 (WIN) improve pain relief by analyzing degree participation CB1 CB2 receptors antinociceptive using an experimental model Wistar rats....
Abstract The master control of mammalian circadian rhythms is the suprachiasmatic nucleus (SCN), which formed by ventral and dorsal regions. In SCN neurons, GABA has an important function even excitatory actions in adulthood. However, physiological role this neurotransmitter developing unknown. Here, we recorded GABAergic postsynaptic currents (in perforated‐patch configuration using gramicidin) to determine chloride reversal potential (E Cl ) also assessed immunological expression Na‐K‐Cl...