A5012526517- Essential Oils and Antimicrobial Activity
- Pharmacological Effects of Natural Compounds
- Pain Mechanisms and Treatments
- Phytochemistry and Biological Activities
- Neuroscience and Neuropharmacology Research
- Chemical synthesis and alkaloids
- Traditional and Medicinal Uses of Annonaceae
- Genomics, phytochemicals, and oxidative stress
- Medicinal Plants and Neuroprotection
- Medicinal Plant Extracts Effects
- Herbal Medicine Research Studies
- Pomegranate: compositions and health benefits
- Bioactive Compounds and Antitumor Agents
- Natural product bioactivities and synthesis
- Phytochemicals and Antioxidant Activities
- Alkaloids: synthesis and pharmacology
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Plant-based Medicinal Research
- Ethnobotanical and Medicinal Plants Studies
- Psychedelics and Drug Studies
- Neuropeptides and Animal Physiology
- Plant biochemistry and biosynthesis
- Natural Antidiabetic Agents Studies
- Biochemical Analysis and Sensing Techniques
- Moringa oleifera research and applications
Instituto Nacional de Psiquiatría
2016-2025
Universidad Nacional Autónoma de México
1998-2022
Secretaria de Salud
2022
The rationale of this investigation was to examine the antinociceptive properties essential oil obtained from Rosmarinus officinalis aerial parts, using a rat model arthritic pain. (100, 300 and 600 mg/kg, I. P.) produced dose-dependent effect, manifested as significant reduction in dysfunction pain-induced functional impairment (PIFIR model), mainly at high doses. Chemical constituents were further analyzed by gas chromatography-mass spectrometry (GC/MS). major compounds alpha-pinene (14.10...
Abstract Background Rutin is a bioflavonoid found in fruits, vegetables and plants used traditional medicine to alleviate pain. However, rutin's scientific evidence for the modulation of pain its mechanism action lacking. It well known that periaqueductal grey matter ( PAG ) contains opioidergic neural circuits involved descending nociception. The aim this study was investigate if antinociceptive activity rutin modulated by circuitry involving participation opioid receptors. Methods...
Tagetes lucida Cav. (Asteraceae) is an ancient medicinal plant commonly used to alleviate pain. Nevertheless, scientific studies validating this property are lacking in the literature. Animal models of pain were evaluate antinociceptive and anti-inflammatory activities T. essential oil (TLEO) a bioactive metabolite. The chemical constitution possible toxicity extract mechanism action β-caryophyllene also explored. Temporal course curves dose–response graphics generated using TLEO (0.1–10...
Pomegranate (Punica granatum L.) has been used for centuries the treatment of inflammatory diseases. However, there is a lack comprehensive information focused on properties certain pomegranate (poly)phenolic profile to cure pain and gastric injury induced by anti-inflammatory drugs. This study investigated systemic effects different doses HPLC-characterized extract formalin-induced nociceptive behavior in mice. The effect against caused non-steroidal drugs ethanol was also assessed. reduced...
Neuropathic pain is caused by a primary lesion, dysfunction, or transitory perturbation in the peripheral central nervous system. In this study, we investigated hesperidin antihyperalgesic effects alone combined with diosmin model of neuropathic to corroborate possible synergistic antinociceptive activity. Mechanical and thermal hyperalgesia were assessed aesthesiometer plantar tests, respectively, after chronic constriction injury (CCI) rats receiving (HS, 5 doses from 10 1000 mg/kg) (DS,...
Tilia genus is commonly used around the world for its central nervous system properties; it prepared as tea and tranquilizing, anticonvulsant, analgesic. In this study, anticonvulsant activity of americana var. mexicana inflorescences leaves was investigated by evaluating organic aqueous extracts (100, 300, 600 mg/kg, i.p.) some flavonoids in pentylenetetrazole-induced seizures mice. Moreover, antioxidant effect these examined an vitro study using spectrophotometric technique. Significant...
Rutin is a bioflavonoid found in medicinal plants used to reduce anxiety. Evidence lacking of rutin’s anxiolytic-like activity, putative mechanism(s) action, and neural sites effects. The basolateral amygdala (BLA) the main brain region that regulates anxiety, through GABA A /benzodiazepine (BDZ) receptors, which are modulated by flavonoids. Therefore, aim this study was investigate whether effect rutin involves /BDZ receptors BLA. administered systemically (30–1000 mg/kg, intraperitoneal)...
Previous reports described the antidepressant-like action of aqueous extract pomegranate (
Agastache mexicana is a plant in high demand that has long been used Mexican folk medicine to treat anxiety, insomnia, and stomachache, among other afflictions. Ursolic acid acacetin were isolated identified as two possible active compounds of A. aerial parts. An antinociceptive response was demonstrated significant dose-dependent manner with ursolic (i. p. o.) comparison the analgesic diclofenac by using writhing test mice. Moreover, also produced concentration-dependent spasmolytic major...