A5047795199- Pharmacological Effects and Toxicity Studies
- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- Metabolism and Genetic Disorders
- Phytochemistry and Biological Activities
- Pharmacology and Obesity Treatment
- Mitochondrial Function and Pathology
- Tryptophan and brain disorders
- Diet and metabolism studies
- Neuropeptides and Animal Physiology
- Drug Transport and Resistance Mechanisms
- Essential Oils and Antimicrobial Activity
- Receptor Mechanisms and Signaling
- Pharmaceutical studies and practices
- Botulinum Toxin and Related Neurological Disorders
- Memory and Neural Mechanisms
- Adipose Tissue and Metabolism
- Health Systems, Economic Evaluations, Quality of Life
- Stress Responses and Cortisol
- Biochemical Acid Research Studies
- Phytochemicals and Antioxidant Activities
- Amino Acid Enzymes and Metabolism
- Global Cancer Incidence and Screening
- Latin American Urban Studies
- Lipid Membrane Structure and Behavior
Instituto Nacional de Pediatria
2010-2023
The University of Texas at El Paso
2023
National Institute of Genomic Medicine
2019
Instituto de Historia
2014-2017
Universidad de la República
2014-2017
National Hospital of Pediatrics
2015-2016
Universidad Nacional Autónoma de México
1999-2014
Centro de Investigación en Materiales Avanzados
2009
University of Ferrara
2004
Early cognitive deficit characteristic of early Alzheimer's disease seems to be produced by the soluble forms beta-amyloid protein. Such correlates with neuronal network dysfunction that is reflected as alterations in electroencephalogram both Alzheimer patients and transgenic murine models such disease. Correspondingly, recent studies have demonstrated chronic exposure betaAP affects hippocampal oscillatory properties. However, it still unclear if results from a direct action on circuit or...
Kynurenic acid (KYNA), an astrocyte-derived, endogenous antagonist of α7 nicotinic acetylcholine and excitatory amino receptors, regulates glutamatergic, GABAergic, cholinergic dopaminergic neurotransmission in several regions the rodent brain. Synthesis KYNA brain elsewhere is generally attributed to enzymatic conversion L-kynurenine (L-KYN) by kynurenine aminotransferases (KATs). However, alternative routes, including formation from D-kynurenine (D-KYN) D-amino oxidase (DAAO) direct...
Tilia genus is commonly used around the world for its central nervous system properties; it prepared as tea and tranquilizing, anticonvulsant, analgesic. In this study, anticonvulsant activity of americana var. mexicana inflorescences leaves was investigated by evaluating organic aqueous extracts (100, 300, 600 mg/kg, i.p.) some flavonoids in pentylenetetrazole-induced seizures mice. Moreover, antioxidant effect these examined an vitro study using spectrophotometric technique. Significant...
Epilepsy is a neurological disorder that can produce brain injury and neuronal death. Several factors such as oxidative stress have been implicated in epileptogenesis. Valproic acid (VPA) widely used drug for the treatment of epilepsy, but mechanisms underlying these benefits are complex still not fully understood. The objective this study was to evaluate, first time, effects VPA on oxidant‐antioxidant status Mexican epileptic children before after 6 or 12 months with by determining...
Obesity is a health problem that requires substantial efforts to understand the physiopathology of its various types and determine therapeutic strategies for treatment. The objective this study was characterize differences in global gene expression profiles subcutaneous adipose tissue (SAT) visceral (VAT) between control patients (normal weight) with obesity (IMC≥30) using microarrays.Employing RNA isolated from SAT VAT samples obtained eight class I, II III obesity, were compared...
Purpose: The objective of this study was to determine whether a comorbidity index could be used predict mortality in pediatric patients with chemotherapy-treated solid tumors. Methods: Pediatric who underwent chemotherapy treatment for tumors were included, and demographic, clinical, data obtained from patient electronic records. Results: A total 196 embryonic included. Metastatic the most frequently observed (n = 103, 52.6%). common comorbidities encountered Charlson (CCI) cellulitis 24,...
Around the world, species from genus Tilia are commonly used because of their peripheral and central medicinal effects; they prepared as teas tranquilizing, anticonvulsant, analgesic agents. In this study, we provide evidence protective effects organic aqueous extracts (100 mg/kg, i.p.) obtained leaves americana var. mexicana on CCl4-induced liver brain damage in rat. Protection was observed (cerebellum, cortex cerebral hemispheres) by measuring activity antioxidant enzymes levels...
Abstract The neuropeptide nociceptin/orphanin FQ (N/OFQ) has been suggested to play a facilitatory role in kainate seizure expression. Furthermore, mRNA levels for the N/OFQ precursor are increased following seizures, while its receptor (NOP) density is decreased. These data suggest release. To obtain direct evidence that this case, we have developed microdialysis technique, coupled with sensitive radioimmunoassay, allows measurement of release from hippocampus and thalamus awake, freely...
Epilepsy is a neuronal disease that affects up to 70 million people worldwide. The development of effective therapies combat childhood epilepsy requires early biomarkers. Here, we performed whole-genome microarray analysis in blood cells identify genes differentially expressed between epileptic and valproic acid (VPA)-treated children versus normal obtain information about the gene expression help us understand genetic aspects this disease. We found most significant were related...
Kainic acid (KA) has been used to study the neurotoxicity induced after status epilepticus (SE) due activation of excitatory amino acids with neuronal damage. Medicinal plants can protect against damage caused by KA-induced SE; in particular, organic extracts Heterotheca inuloides and its metabolite quercetin display antioxidant activity act as hepatoprotective agents. However, it is unknown whether these properties hyperexcitability underlying SE. Our aim was protective effects (with regard...