A5006473694- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Neuroinflammation and Neurodegeneration Mechanisms
- Circadian rhythm and melatonin
- Heavy Metal Exposure and Toxicity
- Cancer-related cognitive impairment studies
- Economic and Financial Impacts of Cancer
- Health Systems, Economic Evaluations, Quality of Life
- Pituitary Gland Disorders and Treatments
- Hemoglobinopathies and Related Disorders
- Radiomics and Machine Learning in Medical Imaging
- Artificial Intelligence in Healthcare
- Esophageal and GI Pathology
- Bipolar Disorder and Treatment
- Advances in Oncology and Radiotherapy
- Mental Health Research Topics
- Blood transfusion and management
- Artificial Intelligence in Healthcare and Education
- Sesame and Sesamin Research
- Cynara cardunculus studies
- Global Healthcare and Medical Tourism
- Adrenal Hormones and Disorders
- Diverticular Disease and Complications
- Hops Chemistry and Applications
- Cannabis and Cannabinoid Research
Instituto Nacional de Neurología y Neurocirugía
2015-2024
Morehouse School of Medicine
2023-2024
Secretaria de Salud
2022
Universidad Nacional Autónoma de México
2017
Friedrich Schiller University Jena
2014
Kynurenic acid (KYNA), an astrocyte-derived, endogenous antagonist of α7 nicotinic acetylcholine and excitatory amino receptors, regulates glutamatergic, GABAergic, cholinergic dopaminergic neurotransmission in several regions the rodent brain. Synthesis KYNA brain elsewhere is generally attributed to enzymatic conversion L-kynurenine (L-KYN) by kynurenine aminotransferases (KATs). However, alternative routes, including formation from D-kynurenine (D-KYN) D-amino oxidase (DAAO) direct...
L-kynurenine (L-KYN) is an endogenous metabolite, that has been used as a neuroprotective strategy in experimental models. The protective effects of L-KYN have attributed mainly to kynurenic acid (KYNA). However, considering prone oxidation, this redox property may play substantial role its effects. aim work was characterize the potential impact properties L-KYN, both synthetic and biological systems. First, we determined whether scavenges reactive oxygen species (ROS) prevents DNA protein...
Previous reports described the antidepressant-like action of aqueous extract pomegranate (
Copper is an integral component of various enzymes, necessary for mitochondrial respiration and other biological functions. Excess copper related with neurodegenerative diseases as Alzheimer able to modify cellular redox environment, influencing its functions, signaling, catabolic pathways. Tryptophan degradation through kynurenine pathway produces some metabolites properties 3‐hydroxykynurenine (3‐HK) 3‐hydroxyanthranilic acid (3‐HANA). The imbalance in their production neuropathologies,...
Aging is a physiological decline process. The number of older adults growing around the world; therefore, incidence cognitive impairment, dementia, and other diseases related to aging increases. main cellular factors that converge in process are mitochondrial dysfunction, antioxidant inflammation, immune response decline, among others. In this context, these changes have an influence on kynurenine pathway (KP), route tryptophan (Trp) catabolism. KP metabolites been involved neurodegenerative...
Background Poststroke depression (PSD) is related to adverse functional and cognitive prognosis in stroke patients. The participation of kynurenine pathway metabolites has been previously proposed; however, there are few studies on its role PSD disability stroke. Objective To investigate if a correlation between serum kynurenines levels with poststroke anxiety symptoms scales. Methods A cross-sectional case-control study was conducted patients first stroke, >1 month <1 year evolution,...
Kynurenine 3-monooxygenase (KMO), a key player in the kynurenine pathway (KP) of tryptophan degradation, regulates synthesis neuroactive metabolites 3-hydroxykynurenine (3-HK) and kynurenic acid (KYNA). KMO activity has been implicated several major brain diseases including Huntington's disease (HD) schizophrenia. In brain, is widely believed to be predominantly localized microglial cells, but verification vivo not provided so far. Here, we examined KP metabolism after depleting cells...
The tryptophan (Trp) metabolite kynurenic acid (KYNA) is an α7-nicotinic and N-methyl-d-aspartate receptor antagonist. Elevated brain KYNA levels are commonly seen in psychiatric disorders neurodegenerative diseases may be related to cognitive impairments. Recently, we showed that N-acetylcysteine (NAC) inhibits kynurenine aminotransferase II (KAT II), KYNA’s key biosynthetic enzyme, reduces neosynthesis rats vivo. In this study, examined if repeated systemic administration of NAC influences...
Abstract The immature brain is especially vulnerable to lead (Pb 2+ ) toxicity, which considered an environmental neurotoxin. Pb exposure during development compromises the cognitive and behavioral attributes persist even later in adulthood, but mechanisms involved this effect are still unknown. On other hand, kynurenine pathway metabolites modulators of different receptors neurotransmitters related cognition; specifically, high kynurenic acid levels has been with impairment, including...
Lead (Pb2+) exposure during early life induces cognitive impairment, which was recently associated with an increase in brain kynurenic acid (KYNA), antagonist of NMDA and alpha-7 nicotinic receptors. It has been described that N-acetylcysteine (NAC) favors antioxidant environment inhibits kynurenine aminotransferase II activity (KAT II, the main enzyme KYNA production), leading to levels decrease improvement. This study aimed investigate whether NAC modulation mice ameliorated Pb2+-induced...
Endurance and resistance exercises, alone or in combination, induce metabolic changes that affect tryptophan (Trp) catabolism. The kynurenine pathway (KP) is the main route of Trp degradation, it modulated by inflammatory redox environments. Previous studies have shown KP metabolites work as myokines mediate positive systemic effects related to exercise. However, poorly understood how different exercise modalities intensities impact KP. aim this study was characterize effect two modalities,...
Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor. The enzyme indoleamine-2,3-dioxygenase (IDO), which participates in rate-limiting step of tryptophan catabolism through kynurenine pathway (KP), associated with poor prognosis patients GBM. metabolites produced after oxidation have immunomodulatory properties that can support immunosuppressor environment. In this study, mRNA expression, protein activity monooxygenase (KMO) were analyzed GBM cell lines (A172,...