A5004511214- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Glioma Diagnosis and Treatment
- Immune cells in cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer-related cognitive impairment studies
- Neuroendocrine regulation and behavior
- Chemokine receptors and signaling
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Electrochemical Analysis and Applications
- Ferroptosis and cancer prognosis
- Horticultural and Viticultural Research
- Circadian rhythm and melatonin
- Hops Chemistry and Applications
- Cancer-related molecular mechanisms research
- Lysosomal Storage Disorders Research
- Heavy Metal Exposure and Toxicity
- Ginseng Biological Effects and Applications
- Arsenic contamination and mitigation
- Epigenetics and DNA Methylation
- Neuroscience of respiration and sleep
- Genetic Neurodegenerative Diseases
- Gut microbiota and health
Northwestern University
2023-2024
Neurological Surgery
2024
Instituto Nacional de Neurología y Neurocirugía
2015-2023
Introduction Glioblastoma multiforme (GBM) pathobiology is characterized by its significant induction of immunosuppression within the tumor microenvironment, predominantly mediated immunosuppressive tumor-associated myeloid cells (TAMCs). Myeloid play a pivotal role in shaping GBM microenvironment and influencing immune responses, with direct interactions effector critically impacting these processes. Methods Our study investigates CXCR6/CXCL16 axis T-cell tissues. We examined surface...
L-kynurenine (L-KYN) is an endogenous metabolite, that has been used as a neuroprotective strategy in experimental models. The protective effects of L-KYN have attributed mainly to kynurenic acid (KYNA). However, considering prone oxidation, this redox property may play substantial role its effects. aim work was characterize the potential impact properties L-KYN, both synthetic and biological systems. First, we determined whether scavenges reactive oxygen species (ROS) prevents DNA protein...
Kynurenine 3-monooxygenase (KMO), a key player in the kynurenine pathway (KP) of tryptophan degradation, regulates synthesis neuroactive metabolites 3-hydroxykynurenine (3-HK) and kynurenic acid (KYNA). KMO activity has been implicated several major brain diseases including Huntington's disease (HD) schizophrenia. In brain, is widely believed to be predominantly localized microglial cells, but verification vivo not provided so far. Here, we examined KP metabolism after depleting cells...
Abstract The immature brain is especially vulnerable to lead (Pb 2+ ) toxicity, which considered an environmental neurotoxin. Pb exposure during development compromises the cognitive and behavioral attributes persist even later in adulthood, but mechanisms involved this effect are still unknown. On other hand, kynurenine pathway metabolites modulators of different receptors neurotransmitters related cognition; specifically, high kynurenic acid levels has been with impairment, including...
Kynureninase (KYNU) is a kynurenine pathway (KP) enzyme that produces metabolites with immunomodulatory properties. In recent years, overactivation of KP has been associated poor prognosis several types cancer, in particular by promoting the invasion, metastasis, and chemoresistance cancer cells. However, role KYNU gliomas remains to be explored. this study, we used available data from TCGA, CGGA GTEx projects analyze expression healthy tissue, as well potential contribution tumor immune...
The activation of the maternal immune system by a prenatal infection is considered risk factor for developing psychiatric disorders in offspring. Toxoplasma gondii one pathogenic infections associated with schizophrenia. Recent studies have shown an association between high levels IgG anti-T. from mothers and their neonates, higher absence parasite IgGs found early stages life suggest transplacental transfer antibodies, which could bind fetal brain structures molecular mimicry induce...
Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor. The enzyme indoleamine-2,3-dioxygenase (IDO), which participates in rate-limiting step of tryptophan catabolism through kynurenine pathway (KP), associated with poor prognosis patients GBM. metabolites produced after oxidation have immunomodulatory properties that can support immunosuppressor environment. In this study, mRNA expression, protein activity monooxygenase (KMO) were analyzed GBM cell lines (A172,...
Indoleamine dioxygenase (IDO), a rate limiting enzyme of the tryptophan catabolism through kynurenine pathway (KP), has been related with lower survival and poor patient prognosis on several solid tumors, including gliomas. However, use IDO inhibitors as therapeutic strategy for tumor treatment remains controversial in clinical trials role other KP enzymes progression remained poorly understood so far. Recently, different studies types cancer have pointed out importance downstream IDO....
Abstract Glioblastoma (GBM) presents as a highly aggressive and malignant brain tumor with limited treatment options. Despite the availability of existing therapies, invasive characteristics GBM frequently result in recurrence poor prognosis. We previously developed B-cell-based therapy (BVax) that has shown promising results its ability to induce therapeutic responses preclinical models GBM. Our research revealed potency BVax can be attributed robust antigen-presenting capability, cognate...
Abstract INTRODUCTION Glioblastoma (GBM) stands as the most frequent and aggressive of primary brain tumors. GBM-driven immunomodulatory mechanisms induce T-cell exhaustion or senescence leading to impaired anti-tumor responses. Telomeres are nucleoprotein complexes located at ending regions eukaryotic chromosomes that become shorter during each cell cycle due cellular stress DNA damage response arrest. Tumor-associated associated with telomere loss on different tumor models still represents...
Abstract INTRODUCTION Glioblastoma (GBM) is the most common and aggressive primary brain tumor with a poor prognosis no curative treatment. Immunotherapy, revolutionizing oncology, currently ineffective for GBM due to immunosuppressive microenvironment. A critical driver tumor-associated macrophages (TAMs) infiltration, which correlated T-cell deficiency progression. While interactions between TAMs T-cells are known inhibit antitumor functions, mechanisms driving these in still not...
Abstract The last decade witnessed tremendous improvement in immunotherapy to treat cancers. Its application GBM has been particularly challenging due the immunosuppressive tumor microenvironment, which greatly challenges T-cell infiltration and function. We developed a B-cell therapy with potent antigen-presenting functions that promote CD8+ tropism persistence microenvironment. present study investigates how BVax activates T cells differently from other professional APCs like dendritic...
Abstract Glioblastoma (GBM) is the most common brain malignancy in adults and has a dismal prognosis. Advances standard-of-care treatments for GBM have not kept pace with those other malignancies, part due to inefficacy of immunotherapies treating GBM. The tumor microenvironment (TME) heavily populated pro-tumorigenic tumor-associated macrophages (TAMs) lacks robust infiltration T cells. Given that number TAMs TME correlates poor prognosis, understanding mechanisms by which they thrive...