A5005501707- Garlic and Onion Studies
- Genomics, phytochemicals, and oxidative stress
- Tryptophan and brain disorders
- Nephrotoxicity and Medicinal Plants
- Stress Responses and Cortisol
- Biochemical Acid Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Mitochondrial Function and Pathology
- Pregnancy and Medication Impact
- Chemotherapy-induced organ toxicity mitigation
- Antibiotics Pharmacokinetics and Efficacy
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Fungal Plant Pathogen Control
- Genetic Neurodegenerative Diseases
- Curcumin's Biomedical Applications
- Free Radicals and Antioxidants
- Adipose Tissue and Metabolism
- Heme Oxygenase-1 and Carbon Monoxide
- Heavy Metal Exposure and Toxicity
- Biochemical effects in animals
- Alzheimer's disease research and treatments
- Ginger and Zingiberaceae research
- Aluminum toxicity and tolerance in plants and animals
- Cholinesterase and Neurodegenerative Diseases
Universidad Nacional Autónoma de México
2000-2023
Instituto Nacional de Neurología y Neurocirugía
2014-2023
Institut Català d'Investigació Química
2014
Pronatura Noroeste
2011
Universidad Autónoma Metropolitana
2005-2011
University of Alaska Fairbanks
2011
Geranium niveum S. Watson (Geraniaceae) is a medicinal herb widely used by the Tarahumara Indians of Mexico. This species rich in proanthocyanidins and other phenolics. Previous vitro assays have demonstrated that exhibited antiinflammatory, antiviral, antibacterial, enzyme-inhibiting, antioxidant, radical-scavenging properties. In view its use chemical composition, aim present study was to determine antioxidant activity extracts two (geranins A D) from roots G. using seven different assay...
Parkinson's disease has been associated with the selective loss of neurons in substantia nigra pars compacta. Increasing evidence suggests that oxidative stress plays a major role. The resulting increase reactive oxygen species triggers sequence events leads to cell damage, activation microglia cells and neuroinflammatory responses. Our objective was study whether chronic exposure low doses ozone, which produces itself, induces progressive death conjunction glial alterations nigra. Animals...
Abstract Background Potassium dichromate (K 2 Cr O 7 )-induced nephrotoxicity is associated with oxidative and nitrosative stress. In this study we investigated the relation between time course of stress kidney damage alterations in following antioxidant enzymes: Cu, Zn superoxide dismutase (Cu, Zn-SOD), Mn-SOD, glutathione peroxidase (GPx), reductase (GR), catalase (CAT). Methods Nephrotoxicity was induced rats by a single injection K . Groups animals were sacrificed on days 1,2,3,4,6,8,10,...
We investigated the effects of S-allylcysteine (SAC) on early behavioral alterations, striatal changes in superoxide dismutase (SOD) activity, lipid peroxidation (LP) and mitochondrial dysfunction induced by systemic infusion 3-nitropropionic acid (3-NPA) to rats. SAC (300 mg/kg, i.p.), given animals 30 min before 3-NPA (30 prevented hyperkinetic pattern evoked toxin. In addition, alone produced decreased activities manganese- (Mn-SOD) copper/zinc-dependent (Cu,Zn-SOD), increased LP...
Progressive renal damage and hypertension are associated with oxidative nitrosative stress. On the other hand, S-allylcysteine (SAC), most abundant organosulfur compound in aged garlic extract (AG), has antioxidant properties. The effects of SAC AG on blood pressure, damage, stress were studied five-sixths nephrectomized rats treated (200 mg/kg ip) (1.2 ml/kg every day for 30 days. Proteinuria serum creatinine urea nitrogen concentrations measured days 0, 5, 10, 15, 30, systolic pressure was...
Experimental evidence on the protective properties of S-allylcysteine (SAC) was collected from three models exerting striatal toxicity. In first model, SAC (120mg kg−1×5) prevented lipoperoxidation (LP) and mitochondrial dysfunction (MD) in synaptosomal fractions 1-methyl-4-phenyl-1,2,3,6-tetrahydropiridinium-treated mice (30mg kg−1), but without complete restoration dopamine levels. second (300mg kg−1×3), LP MD synaptosomes rats infused with 6-hydroxydopamine (8µg µl−1) into substantia...