A5035700556- Pituitary Gland Disorders and Treatments
- Glioma Diagnosis and Treatment
- Garlic and Onion Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Growth Hormone and Insulin-like Growth Factors
- Adrenal and Paraganglionic Tumors
- Nerve injury and regeneration
- Mitochondrial Function and Pathology
- Sirtuins and Resveratrol in Medicine
- Peroxisome Proliferator-Activated Receptors
- Cerebrospinal fluid and hydrocephalus
- Cancer Cells and Metastasis
- Cancer, Hypoxia, and Metabolism
- Retinoids in leukemia and cellular processes
- Genomics, phytochemicals, and oxidative stress
- Ginger and Zingiberaceae research
- Calcium signaling and nucleotide metabolism
- Metabolomics and Mass Spectrometry Studies
- Alzheimer's disease research and treatments
- Angiogenesis and VEGF in Cancer
- Neurological Disease Mechanisms and Treatments
- Alcohol Consumption and Health Effects
- Vascular Malformations Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Myasthenia Gravis and Thymoma
Instituto Nacional de Neurología y Neurocirugía
2016-2025
Centro Médico ABC
2023
Hospital General de México
2022
Instituto Politécnico Nacional
2005
Center for Research and Advanced Studies of the National Polytechnic Institute
2005
To evaluate the effect of all-trans retinoic acid (ATRA) as treatment for chemotherapy-induced peripheral neuropathy in an experimental animal model and a randomized, double-blinded, controlled trial patients with non-small-cell lung cancer (NSCLC).Forty male Wistar rats were randomized 5 groups: group A, control; groups B C, treated cisplatin; D E, paclitaxel. ATRA (20 mg/kg PO) was administered 15 days C E. We evaluated nerve regeneration-related morphologic changes sciatic nerve,...
The sulfonylurea receptor 1 (SUR1) has been classified as a member of the adenosine triphosphate (ATP)-binding cassette (ABC) transporter superfamily. SUR1, unlike classic ABC transporters, assembles with Kir6.2, forming KATP channels to regulate flux potassium ions. In central nervous system, SUR1 is weakly expressed in some brain regions but induced by pathological conditions different cell types neurovascular unit. Therefore, we first analyzed expression various rat tissues and identify...
Abstract Although dapsone (4,4′‐diaminodiphenylsulfone) has been described as a neuroprotective agent in occlusive focal ischemia rats, its mechanism of action is still unknown. To explore this mechanism, oxidative, inflammatory and apoptotic processes were evaluated the striatum adult rats using model ischemia‐reperfusion (I/R), either with or without treatment. Male Wistar submitted to transient middle cerebral artery occlusion for 2 hr, followed by reperfusion. Rats dosed (12.5 mg/kg...
Stroke is a public health problem due to its high mortality and disability rates; despite these, the pharmacological treatments are limited. Oxidative stress plays an important role in cerebral damage stroke activation of nuclear factor erythroid 2-related 2 (Nrf2) confers protection against oxidative stress. Different compounds, such as diallyl trisulfide (DATS), have ability activate Nrf2. DATS protects induced oxygen-glucose deprivation neuronal cells; however, vivo models ischemia, has...
This study aimed to compare the antioxidant activities of extracts obtained from three plant families and evaluate their therapeutic effect on strokes. Ethanol were either leaf or aerial parts plants Annonaceae (Annona cherimola, A. diversifolia, muricata, purpurea, reticulata), Lamiaceae (Salvia amaríssima S. polystachya), Geraniaceae (Geranium niveum G. mexicanum). Extracts analyzed in terms hydroxyl radical (OH•), peroxyl (ROO•), superoxide anion (O2•−). The efficiency prevent neuronal...
Neurocysticercosis is a common parasitic disease in the CNS humans caused by metacestode Taenia solium, with high incidence developing countries. Albendazole drug of choice. However, wide interindividual variability response has been reported. In order to evaluate alternative treatment options, vitro efficacy nitazoxanide, its main metabolite tizoxanide as well and albendazole sulphoxide combination was tested against crassiceps cysts.T. cysts were incubated culture medium containing...
A glioblastoma is an aggressive form of a malignant glial-derived tumor with poor prognosis despite multimodal therapy approaches. Lactate has preponderant role in the microenvironment, playing immunoregulatory as well being carbon source for growth. homeostasis depends on proper functioning intracellular lactate regulation systems, such transporters and enzymes involved its synthesis degradation, evidence that overload generates metabolic stress cells cell death. We propose delivery carried...
Primary central nervous system atypical teratoid/rhabdoid tumors mostly occur during early childhood and are almost invariably fatal. These show similar histological radiological features to primitive neuroectodermal tumor, meduloblastoma choroid plexus carcinoma, but present different biological behaviors. We the case of an 18 year-old man who presented headache, vomiting ataxia. CT-scan MRI revealed a posterior fossa tumor. A gross total resection was performed. An intraoperative study...
After transient cerebral ischemia and reperfusion (I/R), damaging mechanisms, such as excitotoxicity oxidative stress, lead to irreversible neurological deficits. The induction of metallothionein-II (MT-II) protein is an endogenous mechanism after I/R. Our aim was evaluate the neuroprotective effect MT-II I/R in rats. Male Wistar rats were transiently occluded at middle artery for 2 h, followed by reperfusion. Rats received either MT (10 μ g per rat i.p.) or vehicle ischemia. Lipid...
Glucose transporter (GLUT)3 up-regulation is an adaptive response activated to prevent cellular damage when brain metabolic energy reduced. Resveratrol a natural polyphenol with anti-oxidant and anti-inflammatory features that protects neurons against induced in cerebral ischemia. Since transcription factors sensitive oxidative stress inflammation modulate GLUT3 expression, the purpose of this work was assess effect resveratrol on expression levels after Male Wistar rats were subjected 2 h...