A5029652596- Parasitic infections in humans and animals
- Herpesvirus Infections and Treatments
- Multiple Sclerosis Research Studies
- Cerebrospinal fluid and hydrocephalus
- Parasites and Host Interactions
- Congenital Anomalies and Fetal Surgery
- Glioma Diagnosis and Treatment
- Parasite Biology and Host Interactions
- Prion Diseases and Protein Misfolding
- Systemic Lupus Erythematosus Research
- Toxoplasma gondii Research Studies
- Multiple Myeloma Research and Treatments
- Nerve injury and regeneration
- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Autophagy in Disease and Therapy
- Polyomavirus and related diseases
- Peripheral Neuropathies and Disorders
- Parasitic Infections and Diagnostics
- Epilepsy research and treatment
- Anesthesia and Neurotoxicity Research
- Renin-Angiotensin System Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Immunotherapy and Immune Responses
- Neuroblastoma Research and Treatments
Instituto Nacional de Neurología y Neurocirugía
2015-2024
Universidad Nacional Autónoma de México
1997-2024
Academia Nacional de Medicina
2022-2023
Weatherford College
2022-2023
Gobierno de Navarra
2023
Mexican Academy of Sciences
2022-2023
University of California System
2023
Dirección de Investigación y Desarrollo
2022
Center for Research and Advanced Studies of the National Polytechnic Institute
2018
Instituto Politécnico Nacional
2018
Background: Malignant cell clones resistant to chemotherapy and radiotherapy frequently lead treatment failure in patients with glioblastoma multiforme. Preliminary studies suggest that adding chloroquine conventional therapy may improve outcomes. Objective: To examine the effect of for Design: Randomized, double-blind, placebo-controlled trial. Setting: National Institute Neurology Neurosurgery Mexico. Patients: 30 surgically confirmed confined 1 cerebral hemisphere, a Karnofsky performance...
Worldwide, cerebral cysticercosis is one of the most common causes seizure disorders. Modern cysticidal drugs can usually eliminate parasite from brain, but there have been doubts as to whether such treatment improves disorder.
IgM antibodies against cysticercus antigens were measured by enzyme-linked immunosorbent assay (ELISA) in 133 serum and 126 cerebrospinal fluid (CSF) samples from patients with active neurocysticercosis (NCC), 61 32 CSF inactive NCC, 556 449 other neurological disorders. For diagnosis of NCC the test showed 50% sensitivity 70% specificity 87% 95% CSF. We concluded that use ELISA is not reliable for therefore cannot be used routinely detection cases or epidemiological studies. Conversely,...
Ninety-two patients with hydrocephalus secondary to cysticercotic meningitis were followed for a mean period of 8 years 11 months. The mortality rate was 50%, most dying within the first 2 after cerebrospinal fluid (CSF) shunting. prognosis worse in females than males. Multiple surgical procedures shunt obstruction necessary half patients. Complications such as bacterial and more frequent who died those survived. follow-up data revealed that clinical status satisfactory 78% survivors...
Clinical and computerized tomography findings in patients with miliary infestation of cysticerci brain parenchyma are presented. Cysticercotic encephalitis produces a severe frequently fatal neurological disorder. Although parenchymal cysticercosis is common endemic areas, the cases reported here, pathology induced by inflammatory response rather than physical presence multiple cysts. As result diffuse edema, all develop subacute intracranial hypertension compromise visual function. One...
Epidemiological studies suggest that including fruits, vegetables, and whole grains in regular dietary intake might prevent reverse cellular carcinogenesis, reducing the incidence of primary tumours. Bioactive components present food can simultaneously modulate more than one carcinogenic process, cancer metabolism, hormonal balance, transcriptional activity, cell-cycle control, apoptosis, inflammation, angiogenesis metastasis. Some have shown an inverse correlation between a diet rich...
The serums of some patients with subacute spongiform encephalopathies contain an autoantibody in higher titer against a normal fibrillar protein within the axon mature central neurons culture. morphological features this neurofilament, as demonstrated by immunofluorescence and immunoperoxidase staining, partial characterization antibody are described. detection hetero-specific is first evidence immune reaction encephalopathies.
Glioblastoma multiforme (GBM) is the most aggressive of primary brain tumors, with a grim prognosis despite intensive treatment. In past decades, progress in research has not significantly increased overall survival rate.The vitro antineoplastic effect and mechanism action Casiopeina III-ia (Cas III-ia), copper compound, on rat malignant glioma C6 cells was investigated.Cas inhibited cell proliferation, inducing autophagy apoptosis, which correlated formation autophagic vacuoles,...
Object Therapy of malignant tumors is frequently curtailed by the emergence chemoresistant cell clones. Experimentally, authors have demonstrated that chemotherapy for glioma in rats markedly improved administration antimutagenic quinacrine. They studied effects chloroquine, an with optimal pharmacological profile human use, as adjuvant treatment patients glioblastoma multiforme (GBM). Methods In a prospective controlled randomized trial, 18 GBM underwent standard surgery, chemotherapy, and...
Treatment with praziquantel for neurocysticercosis frequently induces adverse reactions due to acute destruction of parasites; these are suppressed by dexamethasone therapy. However, there is controversy about the most appropriate regimen and dexamethasone. We studied plasma levels in eight patients given drug alone or Plasma were 50% lower same patient when was simultaneously. Dexamethasone should not be added therapy as preventive treatment, but reserved transient reactions.
In this work, we investigated the effects of Casiopeina Il-gly (Cas ILgly)—a new copper compound exhibiting antineoplastic activity—on glioma C6 cells under both in vitro and vivo conditions, as an approach to identify potential therapeutic agents against malignant glioma. The exposure Cas Ilgly significantly inhibited cell proliferation, increased reactive oxygen species (ROS) formation, induced apoptosis a dose-dependent manner. cultured cells, caused mitochondrio-nuclear translocation...
Angiotensin II (Ang II) is a main effector peptide in the renin–angiotensin system and participates regulation of vascular tone. It also has role expression growth factors that induce neovascularisation which closely associated to malignant gliomas. We have shown selective blockage AT1 receptor angiotensin inhibites tumour growth, cell proliferation angiogenesis C6 rat glioma. The aim this study was effects on synthesis factors, genesis apoptosis cultured glioma cells rats with...
Recent studies in peripheral blood mononuclear cells (PBMCs) have indicated that exacerbations of multiple sclerosis (MS) could be associated with the reactivation latent varicella-zoster virus (VZV).Ultrastructural observations for viral particles were made by electron microscopy cerebrospinal fluid (CSF) from 15 MS patients during relapse, 19 remission, and 28 control subjects. Initial findings reproduced a confirmation cohort. In addition, DNA VZV was quantified real-time polymerase chain...