A5088670904- Genomics, phytochemicals, and oxidative stress
- Garlic and Onion Studies
- Glutathione Transferases and Polymorphisms
- Redox biology and oxidative stress
- Adipose Tissue and Metabolism
- Curcumin's Biomedical Applications
- Autophagy in Disease and Therapy
- Free Radicals and Antioxidants
- Mitochondrial Function and Pathology
- Fungal Plant Pathogen Control
- Selenium in Biological Systems
- Research on Leishmaniasis Studies
- Alzheimer's disease research and treatments
- Phytochemistry and biological activities of Ficus species
- Cholinesterase and Neurodegenerative Diseases
- Nuclear Receptors and Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Urticaria and Related Conditions
- Cannabis and Cannabinoid Research
- Pharmacological Effects of Natural Compounds
- Cancer therapeutics and mechanisms
- Tryptophan and brain disorders
- Plant Stress Responses and Tolerance
- Ginger and Zingiberaceae research
- Retinoids in leukemia and cellular processes
Instituto Nacional de Neurología y Neurocirugía
2012-2023
The neuroprotective properties of S-allyl cysteine (SAC) have been demonstrated in different neurotoxic paradigms, and it may be partially attributable to its antioxidant anti-inflammatory profile. Recently, SAC has also shown induce neuroprotection the rat striatum a toxic model induced by 6-hydroxydopamine rats through concerted response involving Nrf2 transcription factor nuclear transactivation Phase 2 enzymes' upregulation. In this work, we investigated whether SAC-induced vivo striatal...
In the present study we investigated participation of brain-derived neurotropic factor (BDNF) on activation mitogen activated protein kinase (MAPK) extracellular signal-regulated kinase-1/2 (ERK1/2) as a mechanism curcumin (CUR) to provide an antioxidant defense system mediated by nuclear erythroid 2-related 2 (Nrf2) in neurotoxic model induced quinolinic acid (QUIN). Wistar rats received CUR (400 mg/kg, intragastrically) for 6 days after intrastriatal injection with QUIN (240 nmol)....
Stroke is a public health problem due to its high mortality and disability rates; despite these, the pharmacological treatments are limited. Oxidative stress plays an important role in cerebral damage stroke activation of nuclear factor erythroid 2-related 2 (Nrf2) confers protection against oxidative stress. Different compounds, such as diallyl trisulfide (DATS), have ability activate Nrf2. DATS protects induced oxygen-glucose deprivation neuronal cells; however, vivo models ischemia, has...
Tuberculosis (TB) is one of the ten leading causes death worldwide. Patients with TB have been observed to suffer from depression and anxiety linked social variables. Previous experiments found that substantial pulmonary inflammation associated neuroinflammation, neuronal death, behavioral impairments in absence brain infection. Curcumin (CUR) a natural product antioxidant, anti-inflammatory antibacterial activities. In this work, we evaluated CUR effect on growth control mycobacteria lungs...
Stroke represents one of the main causes death and disability in world; despite this, pharmacological therapies against stroke remain insufficient. Ischemic is leading etiology stroke. Different molecular mechanisms, such as excitotoxicity, oxidative stress, inflammation, participate cell tissue damage. At a preclinical level, different garlic compounds have been evaluated these mechanisms. Additionally, there evidence supporting participation other mechanisms that contribute to brain...
Abstract Quinolinic acid (QUIN) is an agonist of N-methyl-D-aspartate receptor (NMDAr) used to study excitotoxicity in animal models. Striatal QUIN administration increases intracellular Ca 2+ and oxidative stress, induces cellular damage activates different mechanisms death. There evidence indicating that impairment autophagy at early times contributes excitotoxicity; however, the status model 7 days remain unexplored. In this study, ultrastructural analysis subcellular compartments...