A5034059496- Renin-Angiotensin System Studies
- Hormonal Regulation and Hypertension
- Ion Transport and Channel Regulation
- Protein Hydrolysis and Bioactive Peptides
- Renal Diseases and Glomerulopathies
- Genomics, phytochemicals, and oxidative stress
- Trace Elements in Health
- Garlic and Onion Studies
- Renal cell carcinoma treatment
- Glutathione Transferases and Polymorphisms
- Chronic Kidney Disease and Diabetes
- Nitric Oxide and Endothelin Effects
- Nutrition, Genetics, and Disease
- Chromium effects and bioremediation
- Receptor Mechanisms and Signaling
- Protein Kinase Regulation and GTPase Signaling
- Heavy Metal Exposure and Toxicity
- Liver Disease Diagnosis and Treatment
- Pregnancy and Medication Impact
- Vitamin K Research Studies
- Chemotherapy-induced organ toxicity mitigation
- Pancreatic function and diabetes
- Apelin-related biomedical research
- Mechanisms of cancer metastasis
- Cholesterol and Lipid Metabolism
Universidad Nacional Autónoma de México
2000-2025
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
1984-1998
Mineral Resources
1994
National Institute of Nutrition
1989
Abstract Background Potassium dichromate (K 2 Cr O 7 )-induced nephrotoxicity is associated with oxidative and nitrosative stress. In this study we investigated the relation between time course of stress kidney damage alterations in following antioxidant enzymes: Cu, Zn superoxide dismutase (Cu, Zn-SOD), Mn-SOD, glutathione peroxidase (GPx), reductase (GR), catalase (CAT). Methods Nephrotoxicity was induced rats by a single injection K . Groups animals were sacrificed on days 1,2,3,4,6,8,10,...
Isoliquiritigenin (IsoLQ) is a flavonoid with antioxidant properties and inducer of endoplasmic reticulum (ER) stress. In vitro in vivo studies show that ER stress-mediated hormesis cytoprotective; therefore, natural antioxidants stress inducers have been used to prevent renal injury. Oxidative are some the mechanisms damage involved cisplatin (CP)-induced nephrotoxicity. This study aims explore whether IsoLQ pretreatment induces produces protect against CP-induced nephrotoxicity Lilly...
Clusterin is a glycoprotein induced after renal tubular cell injury. The purpose of this study was to examine the expression clusterin in disease model characterized early its course by predominant glomerular Male Wistar rats (weighing 251 +/- 16 g) were treated with puromycin aminonucleoside (PAN: 15 mg/100 g body wt, subcutaneously; n = 7) or vehicle (control; 8). kidneys harvested 6 d treatment, when nephrotic. mRNA markedly nephrotic (8.5-fold versus control). Immunohistochemistry...
Copper (Cu) and zinc (Zn) were measured in urine, serum tissues from rats with nephrotic syndrome (NS) induced a single subcutaneous dose of puromycin aminonucleoside (PAN; 15 mg/l00 g BW). Control animals pair-fed. Urine was collected daily, the sacrificed on day 10. PAN-nephrotic had proteinuria (days 3-10), high urinary Cu 1,2,4-10) Zn 3-10) excretion. On 10, had: (a) albuminuria, hypoalbuminemia, hypoproteinemia, urine low levels ceruloplasmin; (b) levels; (c) clearance fractional...
1. Serum angiotensin converting enzyme activity (ACEA) and plasma renin (PRA) were determined in rats under different experimental conditions such as: nephrotic syndrome (NS), bilateral nephrectomy (BN), renovascular hypertension (RH), dehydration (DEH), anaesthesia (AN), low sodium diet (LSD) high (HSD), injection with propranolol (PRO) isoprenaline (ISO). 2. PRA increased LSD, AN, NS, RH, DEH IPT groups, decreased HSD, BN, PRO groups. ACEA did not change IPT, DEH, NS group, LSD BN 3....
Puromycin aminonucleoside (PA)-nephrotic rats have a high plasma renin activity (PRA) and low angiotensinogen levels. We measured proteinuria, urine renin, daily, for 11 days after PA injection. Proteinuria were evident on day 5, 6. Peak levels of attained 8. These data suggest that excretion may contribute to its levels, loss limit further increase in PRA.
1. Plasma renin activity (PRA), plasma angiotensin I concentration (ANG I), angiotensinogen (PAC) and the levels of active, total inactive (prorenin) were measured in rats with carbon tetrachloride (CCl4)-induced acute renal failure. Rats treated a single oral dose CCl4 (2.5 mL/kg) killed 1, 2, 3 7 days later. 2. On 1-3 PRA, ANG PAC decreased increased on day 7. Active fell 2 3, (trypsin treatment) augmented 1 diminished prorenin per cent Angiotensin paralleled PRA PAC. The CCl4-induced...
The messenger ribonucleic acid (mRNA) levels of albumin, fibrinogen, alpha 1-acid glycoprotein (pAGP) and transferrin were analyzed in puromycin aminonucleoside (PAN)-treated (nephrotic) pair-fed (PF) rats with the Northern dot blot hybridization techniques. Albumin mRNA nephrotic PF 2- 1.5-fold higher, respectively, than ad-libitum-fed control (C) 6 days after PAN treatment. On day 11, this PAN-treated was 2.5-fold higher 4-fold C rats. A differential expression at level specific mRNAs also...
Rats treated with puromycin aminonucleoside (PAN) developed characteristics of the nephrotic syndrome, including albuminuria, hypoalbuminemia and hyperlipidemia. To study regulation apolipoprotein (apo) A-1 apo E gene expression in rats, we analyzed steady-state levels (SSLs) hepatic intestinal mRNA using Northern technique, plasma high-density lipoprotein (HDL) by biochemical methods. Male Wistar rats were PAN compared pair-fed untreated control at different stages disease. Nephrotic...