A5029985793- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Heavy Metal Exposure and Toxicity
- Circadian rhythm and melatonin
- Biochemical Acid Research Studies
- Gut microbiota and health
- Advanced Glycation End Products research
- Arsenic contamination and mitigation
- Polysaccharides and Plant Cell Walls
- Alzheimer's disease research and treatments
- Lysosomal Storage Disorders Research
- Selenium in Biological Systems
- Bipolar Disorder and Treatment
- Horticultural and Viticultural Research
- Neuroendocrine regulation and behavior
- Paraquat toxicity studies and treatments
- Neuroscience of respiration and sleep
- Mercury impact and mitigation studies
- Electrochemical Analysis and Applications
- Autophagy in Disease and Therapy
- Hops Chemistry and Applications
- Toxoplasma gondii Research Studies
- Pesticide Exposure and Toxicity
- Glutathione Transferases and Polymorphisms
- Virology and Viral Diseases
Instituto Nacional de Neurología y Neurocirugía
2011-2024
Universidad Autónoma Metropolitana
2021-2022
University of Maryland, Baltimore
2020
Universidad Nacional Autónoma de México
2014-2017
L-kynurenine (L-KYN) is an endogenous metabolite, that has been used as a neuroprotective strategy in experimental models. The protective effects of L-KYN have attributed mainly to kynurenic acid (KYNA). However, considering prone oxidation, this redox property may play substantial role its effects. aim work was characterize the potential impact properties L-KYN, both synthetic and biological systems. First, we determined whether scavenges reactive oxygen species (ROS) prevents DNA protein...
Kynurenic acid (KYNA), an astrocyte-derived, endogenous antagonist of α7 nicotinic acetylcholine and excitatory amino receptors, regulates glutamatergic, GABAergic, cholinergic dopaminergic neurotransmission in several regions the rodent brain. Synthesis KYNA brain elsewhere is generally attributed to enzymatic conversion L-kynurenine (L-KYN) by kynurenine aminotransferases (KATs). However, alternative routes, including formation from D-kynurenine (D-KYN) D-amino oxidase (DAAO) direct...
Abstract β‐Amyloid peptide accumulation in the cortex and hippocampus results neurodegeneration memory loss. Recently, it became evident that inflammatory response triggered by peptides promotes neuronal cell death degeneration. In addition to inflammation, also induce alterations autophagy, eventually leading death. Thus, here we evaluated whether induced impairs via disrupting autophagic flux. We show male mice overexpressing (5XFAD) but lacking caspase‐1, presented reduced plaques...
Abstract Background Reactive oxygen species (ROS) are important mediators in a number of degenerative diseases. Oxidative stress refers to the imbalance between production ROS and ability scavenge these through endogenous antioxidant systems. Since antioxidants can inhibit oxidative processes, it becomes relevant describe natural compounds with properties which may be designed as therapies decrease damage stimulate cytoprotective The present study tested protective effect two xanthones...
The tryptophan (Trp) metabolite kynurenic acid (KYNA) is an α7-nicotinic and N-methyl-d-aspartate receptor antagonist. Elevated brain KYNA levels are commonly seen in psychiatric disorders neurodegenerative diseases may be related to cognitive impairments. Recently, we showed that N-acetylcysteine (NAC) inhibits kynurenine aminotransferase II (KAT II), KYNA’s key biosynthetic enzyme, reduces neosynthesis rats vivo. In this study, examined if repeated systemic administration of NAC influences...
Alterations in the composition of gut microbiota may be causally associated with several brain diseases. Indole-3-propionic acid (IPrA) is a tryptophan-derived metabolite, which produced by intestinal commensal microbes, rapidly enters circulation, and crosses blood-brain barrier. IPrA has neuroprotective properties, have been attributed to its antioxidant bioenergetic effects. Here, we evaluate an alternative and/or complementary mechanism, linking kynurenic (KYNA), another tryptophan...
Lead (Pb2+) exposure during early life induces cognitive impairment, which was recently associated with an increase in brain kynurenic acid (KYNA), antagonist of NMDA and alpha-7 nicotinic receptors. It has been described that N-acetylcysteine (NAC) favors antioxidant environment inhibits kynurenine aminotransferase II activity (KAT II, the main enzyme KYNA production), leading to levels decrease improvement. This study aimed investigate whether NAC modulation mice ameliorated Pb2+-induced...
The activation of the maternal immune system by a prenatal infection is considered risk factor for developing psychiatric disorders in offspring. Toxoplasma gondii one pathogenic infections associated with schizophrenia. Recent studies have shown an association between high levels IgG anti-T. from mothers and their neonates, higher absence parasite IgGs found early stages life suggest transplacental transfer antibodies, which could bind fetal brain structures molecular mimicry induce...
Epidemiological studies and meta-analyses have shown a strong association between high seroprevalence of Toxoplasma gondii (T. gondii) schizophrenia. Schizophrenic patients showed higher levels anti-Toxoplasma immunoglobulins M G (IgM IgG) when compared to healthy controls. Previously, in rat model, we demonstrated that the progeny mothers immunized with T. lysates before gestation had behavioral social impairments during adulthood. Therefore, suggested infection can trigger autoreactivity...
Cisplatin (CIS) is a potent chemotherapeutic agent primarily used to treat hematologic malignancies and solid tumors, including lymphomas, sarcomas, some carcinomas. Patients receiving this treatment for tumors outside the nervous system develop cognitive impairment. Alterations in kynurenine pathway (KP) following CIS suggest that certain KP metabolites may cross blood-brain barrier, leading increased production of neuromodulator kynurenic acid (KYNA), which associated with This study aimed...