A5014448554- Pain Mechanisms and Treatments
- Transcranial Magnetic Stimulation Studies
- Stress Responses and Cortisol
- Pain Management and Treatment
- Musculoskeletal pain and rehabilitation
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Anesthesia and Neurotoxicity Research
- Biochemical effects in animals
- Circadian rhythm and melatonin
- Pain Management and Placebo Effect
- Adenosine and Purinergic Signaling
- Neuropeptides and Animal Physiology
- Muscle activation and electromyography studies
- Pediatric Pain Management Techniques
- Regulation of Appetite and Obesity
- Myofascial pain diagnosis and treatment
- Public Health in Brazil
- Neuroscience and Neuropharmacology Research
- Attention Deficit Hyperactivity Disorder
- Tryptophan and brain disorders
- Youth, Drugs, and Violence
- Neuroendocrine regulation and behavior
- Neuroscience of respiration and sleep
Universidade Federal do Rio Grande do Sul
2016-2025
Hospital de Clínicas de Porto Alegre
2016-2025
EsSALUD
2024
Spaulding Rehabilitation Hospital
2019-2023
Universidade Federal do Rio Grande
2013-2023
National Council for Scientific and Technological Development
2023
Universidade Federal do Pampa
2021
Universidade Feevale
2021
Hospital de Clínicas
2017-2021
Harvard University
2021
In public health, mood disorders are among the most important mental impairments. Patients with depressive episodes exhibit daily variations, abnormal patterns in sleep-wake behavior, and rhythms of several endocrine-metabolic parameters. Although relationship between sleep/circadian processes is poorly understood, clock-related therapies, such as light therapy, sleep deprivation, rigid schedules, have been shown to be effective treatments. Several studies investigated circadian phenotype...
Catastrophizing is a maladaptive response to pain and one of the factors that contribute chronicity some syndromes. The Pain Scale (PCS) assists both treatment planning outcome assessment. Its use limited in Portuguese-speaking countries because lack validated translated version. We conducted validation Brazilian Portuguese (BP)-PCS explored its psychometric properties. This study reports internal consistency, factor structure, capability discriminate reported by patients with specific...
The primary aim was to assess the psychometric properties (including internal consistency, construct validity, reproducibility, and factor structure) of Central Sensitization Inventory (CSI), adapted validated for a Brazilian population (CSI-BP). Additionally, we evaluated relationship between CSI-BP serum brain-derived neurotrophic (BDNF) determined if symptoms elicited by discriminate subjects who do/do not respond conditioned pain modulation (CPM) task, as assessed change in numeric scale...
Endometriosis-associated chronic pelvic pain (EACPP) presents with an intense inflammatory reaction. Melatonin has emerged as important analgesic, antioxidant, and antiinflammatory agent. This trial investigates the effects of melatonin compared a placebo on EACPP, brain-derived neurotrophic factor (BDNF) level, sleep quality. Forty females, aged 18 to 45 years, were randomized into (n = 20) or (10 mg) treatment groups for period 8 weeks. There was significant interaction (time vs group)...
Central disinhibition is a mechanism involved in the physiopathology of fibromyalgia. Melatonin can improve sleep quality, pain and threshold. We hypothesized that treatment with melatonin alone or combination amitriptyline would be superior to modifying endogenous pain-modulating system (PMS) as quantified by conditional modulation (CPM), this change CPM could associated serum brain-derived neurotrophic factor (BDNF). also tested whether improves clinical symptoms pain, threshold quality....
The central sensitization syndrome (CSS) encompasses disorders with overlapping symptoms in a structural pathology spectrum ranging from persistent nociception [e.g., osteoarthritis (OA)] to an absence of tissue injuries such as the one presented fibromyalgia (FM) and myofascial pain (MPS). First, we hypothesized that these syndromes present differences their cortical excitability parameters assessed by TMS, namely motor evoked potential (MEP), silent period (CSP), short intracortical...
This randomized, double-blinded, placebo-controlled trial tested the hypothesis that 20mg of melatonin before and during first cycle adjuvant chemotherapy for breast cancer (ACBC) reduced side effects associated with cognitive impairment. We evaluated on cognition, depressive symptoms sleep quality, whether these were related to serum levels Brain Derived Neurotrophic Factor (BDNF) its receptor, tropomyosin kinase B (TrkB). Thirty-six women randomly assigned receive or placebo 10 days. To...
Obesity is a disease that has become serious public health issue worldwide, and chronic stressors, which are problem for modern society, cause neuroendocrine changes with alterations in food intake. stress associated the development of cardiovascular diseases metabolic disorders. In this study, rat model was used to evaluate effects hypercaloric diet plus restraint on serum leptin lipids levels weight specific adipose tissue (mesenteric, MAT; subcutaneous, SAT visceral, VAT). Wistar rats...
Cognitive dysfunction in fibromyalgia patients has been reported, especially when increased attentional demands are required. Transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) effective modulating attention. We tested effects of a single session tDCS coupled with Go/No-go task three distinct networks: alertness, orienting and executive control. Secondarily, effect on pain measures was evaluated. Forty females were randomized to receive active or...
Transcranial direct current stimulation (tDCS) has been suggested as a therapeutic tool for pain syndromes. Although initial results in human subjects are encouraging, it still remains unclear whether the effects of tDCS can reverse maladaptive plasticity associated with chronic pain. To investigate this question, we tested specific behavioral stress system, and also those indexed by corticosterone interleukin-1β levels serum TNFα hippocampus, well-controlled rat model restraint (CRS)....