A5009469867- Mitochondrial Function and Pathology
- Heme Oxygenase-1 and Carbon Monoxide
- Genomics, phytochemicals, and oxidative stress
- Neuroscience and Neuropharmacology Research
- Cannabis and Cannabinoid Research
- Metabolism and Genetic Disorders
- Adipose Tissue and Metabolism
- Alzheimer's disease research and treatments
- Curcumin's Biomedical Applications
- Metabolomics and Mass Spectrometry Studies
- Neurological Disease Mechanisms and Treatments
- Parkinson's Disease Mechanisms and Treatments
- Garlic and Onion Studies
- Natural Compound Pharmacology Studies
- Neuroscience of respiration and sleep
- Nuclear Receptors and Signaling
- Biochemical effects in animals
- Chemotherapy-induced organ toxicity mitigation
- Trace Elements in Health
- Tryptophan and brain disorders
- Birth, Development, and Health
- Paraquat toxicity studies and treatments
- Neonatal Health and Biochemistry
- Biochemical Acid Research Studies
- Sleep and Wakefulness Research
Instituto Nacional de Cardiología
2023-2024
Instituto Nacional de Neurología y Neurocirugía
2012-2024
Universidad Nacional Autónoma de México
2005-2012
Curcumin is a phenolic yellow curry pigment with anti-inflammatory and antioxidant activities α-mangostin xanthone isolated from mangosteen fruit properties. Iodoacetate (IAA) an inhibitor of the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase that induces model metabolic inhibition in neurons where reactive oxygen species (ROS) production significant mechanism. Furthermore, it has been shown induction heme oxygenase-1 (HO-1) protects against IAA-induced neuronal death.To study...
One of the characteristics cerebral aging process is presence chronic inflammation through glial cells, which particularly significant in neurodegeneration. On other hand, it has been demonstrated that aryl hydrocarbon receptor (AHR) participates inflammatory response. Currently, evidence animal models shows hallmarks are associated with changes AHR levels. However, there no information concerning behavior and participation human brain or Alzheimer’s disease (AD). We evaluated expression...
Unilateral ureteral obstruction (UUO) is an animal rodent model that allows the study of obstructive nephropathy in accelerated manner. During UUO, tubular damage induced, and alterations such as oxidative stress, inflammation, lipid metabolism, mitochondrial impairment favor fibrosis development, leading to chronic kidney disease progression. Sulforaphane (SFN), isothiocyanate derived from green cruciferous vegetables, might improve functions metabolism; however, its role UUO has been...
Abstract Quinolinic acid (QA) triggers striatal neuronal death by an excitotoxic cascade that involves oxidative stress, which in turns is tightly linked to mitochondria. Mitochondrial dysfunction a molecular feature described several brain pathologies. In this work, we determined whether the sulforaphane‐neuroprotective effect rodent experimental model of Huntington's disease induced QA associated with mitochondrial function preservation. We found impaired within 24 h post‐lesion....
Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by increased activation of fibroblasts/myofibroblasts. Previous reports have shown that IPF fibroblasts are resistant to apoptosis, but the mechanisms remain unclear. Since inhibition mitochondrial permeability transition pore (mPTP) has been implicated in resistance this study, we analyzed role function and mPTP on apoptosis under basal conditions after mitomycin C-induced apoptosis. We measured release cytochrome c,...
Aged garlic extract (AGE) and its main constituent S-allylcysteine (SAC) are natural antioxidants with protective effects against cerebral ischemia or cancer, events that involve hypoxia stress. Cobalt chloride (CoCl2) has been used to mimic hypoxic conditions through the stabilization of α subunit inducible factor (HIF-1α) up-regulation HIF-1α-dependent genes as well activation such reactive oxygen species (ROS) generation, loss mitochondrial membrane potential apoptosis. The present study...
Abstract Background Morin is a flavonoid found in many edible fruits. The hippocampus and entorhinal cortex play crucial roles memory formation consolidation. This study aimed to characterize the effect of morin on recognition space healthy C57BL/6 adult mice explore underlying molecular mechanism. Methods was administered i.p. at 1, 2.5, 5 mg/kg/24 h for 10 days. Morris water maze (MWM), novel object recognition, context tasks were conducted 1 day after last administration. mice's brains...
Ginkgo biloba extracts have long been used in Chinese traditional medicine for hundreds of years. The most significant extract obtained from leaves has EGb 761, a widely phytopharmaceutical product Europe. 761 is well-defined mixture active compounds, which contains two main substances: flavonoid glycosides (24–26%) and terpene lactones (6–8%). These compounds shown antiapoptotic effects through the protection mitochondrial membrane integrity, inhibition cytochrome c release, enhancement...
Abstract Nordihydroguaiaretic acid (NDGA) is present in high concentrations the desert shrub Creosote bush, Larrea tridentate. This plant has been used traditional medicine because of its beneficial effects related, at least part, to antioxidant properties. Taking into account some evidence about neuroprotective elicited by NDGA, we evaluated effect this compound on neurotoxicity induced iodoacetate (IAA), an inhibitor glyceraldehyde‐3‐phosphate dehydrogenase (GAPDH), cerebellar granule...