A5061496748- Dementia and Cognitive Impairment Research
- Health disparities and outcomes
- Aging, Health, and Disability
- Alzheimer's disease research and treatments
- Aging, Elder Care, and Social Issues
- Frailty in Older Adults
- Intergenerational Family Dynamics and Caregiving
- Health, Environment, Cognitive Aging
- Parkinson's Disease Mechanisms and Treatments
- Functional Brain Connectivity Studies
- Health Systems, Economic Evaluations, Quality of Life
- Chronic Disease Management Strategies
- Global Health Care Issues
- Mental Health Treatment and Access
- Nutritional Studies and Diet
- Neurological disorders and treatments
- Health and Lifestyle Studies
- Neurological Disorders and Treatments
- Healthcare Systems and Public Health
- Neurobiology of Language and Bilingualism
- Cardiac Health and Mental Health
- Nutrition and Health in Aging
- Neuroinflammation and Neurodegeneration Mechanisms
- Alcoholism and Thiamine Deficiency
- Genetic Neurodegenerative Diseases
Instituto Nacional de Neurología y Neurocirugía
2016-2025
The University of Texas Health Science Center at Houston
2025
Universidad Nacional Autónoma de México
2015-2024
Metropolitan University
2024
Alzheimer’s Disease Neuroimaging Initiative
2023
Secretaria de Salud
2021
ORCID
2020
NTL Institute for Applied Behavioral Science
2016
King's College London
2009-2014
Instituto Nacional de Psiquiatría
2014
Abstract Reducing the risk of dementia can halt worldwide increase affected people. The multifactorial and heterogeneous nature late‐onset dementia, including Alzheimer's disease (AD), indicates a potential impact multidomain lifestyle interventions on reduction. positive results landmark Finnish Geriatric Intervention Study to Prevent Cognitive Impairment Disability (FINGER) support such an approach. World‐Wide FINGERS (WW‐FINGERS), launched in 2017 over 25 countries, is first global...
Latin America, China and India are experiencing unprecedentedly rapid demographic ageing with an increasing number of people dementia. The 10/66 Dementia Research Group's title refers to the 66% dementia that live in developing countries less than one tenth population-based research carried out those settings. This paper describes protocols for intervention studies aim redress this imbalance. Cross-sectional comprehensive phase surveys have been conducted all residents aged 65 over...
A set of cross-sectional surveys carried out in Cuba, Dominican Republic, Peru, Mexico, Venezuela, Puerto Rico, China, and India reveal the prevalence between-country variation mild cognitive impairment at a population level.
<h3>Objectives</h3> Despite the growing importance of stroke in developing countries, little is known burden survivors. The authors investigated prevalence self-reported stroke, stroke-related disability, dependence and care-giver strain Latin America (LA), China India. <h3>Methods</h3> Cross-sectional surveys were conducted on individuals aged 65+ (n=15 022) living specified catchment areas. Self-reported diagnosis, care needs giver assessed using a standardised protocol. For those...
The number of older people is set to increase dramatically worldwide. Demographic changes are likely result in the rise age-related chronic diseases which largely contribute years lived with a disability and future dependence. However dependence much less studied although intrinsically linked disability. We investigated prevalence correlates among from middle income countries. A one-phase cross-sectional survey was carried out at 11 sites seven countries (urban Cuba, Venezuela, Dominican...
In countries with high incomes, frailty indicators predict adverse outcomes in older people, despite a lack of consensus on definition or measurement. We tested the predictive validity physical and multidimensional phenotypes settings Latin America, India, China. Population-based cohort studies were conducted catchment area sites Cuba, Dominican Republic, Venezuela, Mexico, Peru, Seven indicators, namely gait speed, self-reported exhaustion, weight loss, low energy expenditure,...
Abstract We evaluated the psychometric properties of 12‐item interviewer‐administered screener version World Health Organization Disability Assessment Schedule – II (WHODAS II) among older people living in seven low‐ and middle‐income countries. Principal component analysis (PCA), confirmatory factor (CFA) Mokken analyses were carried out to test for unidimensionality, hierarchical structure, measurement invariance across 10/66 Dementia Research Group sites. PCA generated a one‐factor...
Current estimates of the prevalence depression in later life mostly arise from studies carried out Europe, North America and Asia. In this study we aimed to measure using a standardised method number low middle income countries (LMIC). A one-phase cross-sectional survey involving over 17,000 participants aged 65 years living urban rural catchment areas 13 sites 9 (Cuba, Dominican Republic, Puerto Rico, Mexico, Venezuela, Peru, China, India Nigeria). Depression was assessed compared ICD-10...
Objectives In a multi‐site population‐based study in several middle‐income countries, we aimed to investigate relative contributions of care arrangements and characteristics carers recipients strain among people with dementia. Based on previous research, hypotheses focused carer sex, inputs, behavioural psychological symptoms (BPSD) socioeconomic status, together potential buffering effects informal support employing paid carers. Methods catchment area surveys 11 sites Latin America, India...
Abstract Across Latin American and Caribbean countries (LACs), the fight against dementia faces pressing challenges, such as heterogeneity, diversity, political instability, socioeconomic disparities. These can be addressed more effectively in a collaborative setting that fosters open exchange of knowledge. In this work, Consortium on Dementia (LAC‐CD) proposes an agenda for integration to deliver Knowledge Action Framework (KtAF). First, we summarize evidence‐based strategies (epidemiology,...
To date, dementia prediction models have been exclusively developed and tested in high-income countries (HICs). However, most people with live low-income middle-income (LMICs), where risk research is almost non-existent the ability of current to predict unknown. This study investigated whether HICs are applicable LMICs.
Background The World Health Organization (WHO) has reframed health and healthcare for older people around achieving the goal of healthy ageing. recent WHO Integrated Care Older People (ICOPE) guidelines focus on maintaining intrinsic capacity, i.e., addressing declines in neuromusculoskeletal, vitality, sensory, cognitive, psychological, continence domains, aiming to prevent or delay onset dependence. target group with 1 more capacity (DICs) is broad, implementation may be challenging...
The Worldwide Alzheimer's Disease Neuroimaging Initiative (WW-ADNI) is a collaborative effort to investigate imaging and biofluid markers that can inform disease treatment trials. It public-private partnership spans North America, Argentina, Australia, Canada, China, Japan, Korea, Mexico, Taiwan. In 2004, ADNI researchers began naturalistic, longitudinal study continues today around the globe. Through several successive phases (ADNI-1, ADNI-GO, ADNI-2, ADNI-3), has fueled amyloid tau...
The criterion for dementia implicit in DSM-IV is widely used research but not fully operationalised. 10/66 Dementia Research Group sought to do this using assessments from their one phase diagnostic interview, and validate the resulting algorithm a population-based study Cuba. was operationalised as computerised algorithm, applying clinical principles, based upon cognitive tests, interview informant reports; Community Screening Instrument Dementia, CERAD 10 word list learning animal naming...
Abstract Objective Brief screening tools for dementia use by non‐specialists in primary care have yet to be validated non‐western settings where cultural factors and limited education may complicate the task. We aimed derive a brief version of cognitive informant scales from Community Screening Instrument Dementia (CSI‐D) carry out initial assessments their likely validity. Methods applied Mokken analysis CSI‐D scale data 15 022 participants representative population‐based surveys Latin...
Abstract Background 1) To report site-specific normative values by age, sex and educational level for four components of the 10/66 Dementia Research Group cognitive test battery; 2) to estimate main interactive effects sex, site; 3) investigate effect site region rural or urban location. Methods Population-based cross-sectional one phase catchment area surveys were conducted in Cuba, Dominican Republic, Venezuela, Peru, Mexico, China India. The protocol included administration Community...
Background The proportion of the global population aged 60 and over is increasing, more so in Latin America than any other region. Depression common among elderly people an important cause disability worldwide. Aims To estimate prevalence correlates late-life depression, associated access to treatment five locations America. Method A one-phase cross-sectional survey 5886 65 from urban rural Peru Mexico site Venezuela. was identified according DSM–IV ICD–10 criteria, Geriatric Mental...
Abstract Background To describe patterns of recent health service utilisation, and consequent out-of-pocket expenses among older people in countries with low middle incomes, to assess the equity which services are accessed delivered. Methods 17,944 aged 65 years over were assessed one-phase population-based cross-sectional surveys geographically-defined catchment areas nine - urban rural sites China, India, Mexico Peru, Cuba, Dominican Republic, Puerto Rico Venezuela, a site Nigeria. The...
Objectives To estimate the prevalence, social patterning, treatment and control of hypertension among older people in 10/66 Dementia Research Group developing country sites. Methods Cross-sectional surveys SBP, hypertension, awareness, 17 014 aged 65 years over eight urban four rural sites Latin America, India China. Results Hypertension prevalence was higher (range 52.6–79.8%) than 42.6–56.9%), lower men women [pooled ratio 0.89, 95% confidence interval (CI) 0.85–0.93]. Educational...