Stefanie Danielle Piña‐Escudero
A5006248554- Dementia and Cognitive Impairment Research
- Health, Environment, Cognitive Aging
- Alzheimer's disease research and treatments
- Health disparities and outcomes
- Functional Brain Connectivity Studies
- Health Systems, Economic Evaluations, Quality of Life
- Elder Abuse and Neglect
- Genetic Associations and Epidemiology
- Intensive Care Unit Cognitive Disorders
- Aging and Gerontology Research
- Amyotrophic Lateral Sclerosis Research
- Neurobiology of Language and Bilingualism
- Aging, Elder Care, and Social Issues
- S100 Proteins and Annexins
- Aging, Health, and Disability
- Child Abuse and Trauma
- Bioinformatics and Genomic Networks
- Neuroinflammation and Neurodegeneration Mechanisms
- Mental Health and Patient Involvement
- Genomics and Rare Diseases
- Neurological diseases and metabolism
- Genetics, Aging, and Longevity in Model Organisms
- Traumatic Brain Injury Research
- Cognitive Functions and Memory
- Patient Dignity and Privacy
University Memory and Aging Center
2021-2025
University of California, San Francisco
2019-2025
Global Brain Health Institute
2019-2025
Trinity College Dublin
2020-2025
Adolfo Ibáñez University
2023
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
2011-2021
Universidad La Salle
2019
Abstract Brain clocks, which quantify discrepancies between brain age and chronological age, hold promise for understanding health disease. However, the impact of diversity (including geographical, socioeconomic, sociodemographic, sex neurodegeneration) on brain-age gap is unknown. We analyzed datasets from 5,306 participants across 15 countries (7 Latin American Caribbean (LAC) 8 non-LAC countries). Based higher-order interactions, we developed a deep learning architecture functional...
Abstract Across Latin American and Caribbean countries (LACs), the fight against dementia faces pressing challenges, such as heterogeneity, diversity, political instability, socioeconomic disparities. These can be addressed more effectively in a collaborative setting that fosters open exchange of knowledge. In this work, Consortium on Dementia (LAC‐CD) proposes an agenda for integration to deliver Knowledge Action Framework (KtAF). First, we summarize evidence‐based strategies (epidemiology,...
Global brain health initiatives call for improving methods the diagnosis of Alzheimer's disease (AD) and frontotemporal dementia (FTD) in underrepresented populations. However, diagnostic procedures upper-middle-income countries (UMICs) lower-middle income (LMICs), such as Latin American (LAC), face multiple challenges. These include heterogeneity methods, lack clinical harmonisation, limited access to biomarkers.
Dementia poses one of the greatest global health challenges, affecting 50 million people worldwide. With 10 new cases each year, dementia is a growing burden, particularly in low- and middle-income countries (LMIC). This study aimed to identify facilitators barriers providing quality assessment care LMICs from perspective.A qualitative semi-structured interview with 20 expert healthcare providers 19 countries. To be included, had to: practice or where population over age 60 projected more...
Abstract BACKGROUND Education influences brain health and dementia. However, its impact across regions, specifically Latin America (LA) the United States (US), is unknown. METHODS A total of 1412 participants comprising controls, patients with Alzheimer's disease (AD), frontotemporal lobar degeneration (FTLD) from LA US were included. We studied association education volume functional connectivity while controlling for imaging quality variability, age, sex, intracranial (TIV), recording...
To determine the association of five frailty criteria from Cardiovascular Health Study, as well cognitive impairment, with prevalent disability for instrumental (IADL) and basic activities daily living (ADL).
Abstract Limited knowledge on dementia biomarkers in Latin American and Caribbean (LAC) countries remains a serious barrier. Here, we reported survey to explore the ongoing work, needs, interests, potential barriers, opportunities for future studies related biomarkers. The results show that neuroimaging is most used biomarker (73%), followed by genetic (40%), peripheral fluids (31%), cerebrospinal fluid (29%). Regarding barriers LAC, lack of funding appears undermine implementation clinical...
Abstract The Latin American Brain Health Institute (BrainLat) has released a unique multimodal neuroimaging dataset of 780 participants from American. includes 530 patients with neurodegenerative diseases such as Alzheimer’s disease (AD), behavioral variant frontotemporal dementia (bvFTD), multiple sclerosis (MS), Parkinson’s (PD), and 250 healthy controls (HCs). This (62.7 ± 9.5 years, age range 21–89 years) was collected through multicentric effort across five countries to address the need...
Abstract Frontotemporal dementia (FTD) is one of the leading causes before age 65 and often manifests as abnormal behavior (in behavioral variant FTD) or language impairment primary progressive aphasia). FTD's exact clinical presentation varies by culture, language, education, social norms, other socioeconomic factors; current research practice, however, mainly based on studies conducted in North America Western Europe. Changes diagnostic criteria procedures well new adapted cognitive tests...
Abstract Neurodegeneration has multiscalar impacts, including behavioral, neuroanatomical, and neurofunctional disruptions. Can disease-differential alterations be captured across such dimensions using naturalistic stimuli? To address this question, we assessed comprehension of four stories, highlighting action, nonaction, social, nonsocial events, in Parkinson’s disease (PD) behavioral variant frontotemporal dementia (bvFTD) relative to Alzheimer’s patients healthy controls. Text-specific...
Abstract Global initiatives call for further understanding of the impact inequity on aging across underserved populations. Previous research in low- and middle-income countries (LMICs) presents limitations assessing combined sources outcomes (i.e., cognition functionality). In this study, we assessed how social determinants health (SDH), cardiometabolic factors (CMFs), other medical/social predict functionality an Colombian population. We ran a cross-sectional study that theory- (structural...
While education is crucial for brain health, evidence mainly relies on individual measures of years (YoE), neglecting quality (EQ). The effect YoE and EQ aging dementia has not been compared. We conducted a cross-sectional assessment the health in 7533 subjects from 20 countries, including healthy controls (HCs), Alzheimer's disease (AD), frontotemporal lobar degeneration (FTLD). was based country-level indicators provided by programme international student (PISA). After applying neuroimage...
The SARS-CoV-2 global pandemic will disproportionately impact countries with weak economies and vulnerable populations including people dementia. Latin American Caribbean (LACs) are burdened unstable economic development, fragile health systems, massive disparities, a high prevalence of Here, we underscore the selective on dementia among LACs, specific strain systems devoted to dementia, subsequent effect increasing inequalities those in region. Implementation best practices for mitigation...
The faster rates of cognitive decline and predominance atypical forms in early-onset Alzheimer's disease (EOAD) suggest that neuropsychiatric symptoms could be different EOAD compared to late-onset AD (LOAD); however, prior studies based on non-biomarker-diagnosed cohorts show discordant results. Our goal was determine the profile LOAD, a cohort with biomarker/postmortem-confirmed diagnoses. Additionally, contribution co-pathologies explored.In all, 219 participants (135 EOAD, 84 LOAD)...