A5012772846- Neurobiology of Language and Bilingualism
- Dementia and Cognitive Impairment Research
- Language Development and Disorders
- Health, Environment, Cognitive Aging
- Alzheimer's disease research and treatments
- Reading and Literacy Development
- Ethics in Clinical Research
- Air Quality and Health Impacts
- Phonetics and Phonology Research
- Stuttering Research and Treatment
- Spatial Neglect and Hemispheric Dysfunction
- Cerebrovascular and Carotid Artery Diseases
- Second Language Acquisition and Learning
- Cognitive and developmental aspects of mathematical skills
- Action Observation and Synchronization
- Face Recognition and Perception
- Interpreting and Communication in Healthcare
- S100 Proteins and Annexins
- Text Readability and Simplification
- Medical Imaging Techniques and Applications
- Health Systems, Economic Evaluations, Quality of Life
- Amyotrophic Lateral Sclerosis Research
- Acute Ischemic Stroke Management
- Hearing Loss and Rehabilitation
- Functional Brain Connectivity Studies
University Memory and Aging Center
2020-2025
University of California, San Francisco
2018-2025
Global Brain Health Institute
2018-2025
Buddhist Tzu Chi General Hospital
2017-2023
Center for Neurosciences
2023
Trinity College Dublin
2023
Tzu Chi University
2018-2022
Education University of Hong Kong
2022
Hualien Tzu Chi Medical Center
2017-2019
National Taiwan University Hospital
2012-2016
The US aging population is rapidly becoming more racially and ethnically diverse. Early diagnosis of dementia a health care priority.
Abstract INTRODUCTION Clinical research in Alzheimer's disease (AD) lacks cohort diversity despite being a global health crisis. The Asian Cohort for Disease (ACAD) was formed to address underrepresentation of Asians research, and limited understanding how genetics non‐genetic/lifestyle factors impact this multi‐ethnic population. METHODS ACAD started fully recruiting October 2021 with one central coordination site, eight recruitment sites, two analysis sites. We developed comprehensive...
Abstract INTRODUCTION With emergence of disease‐modifying therapies, efficient diagnostic pathways are critically needed to identify treatment candidates, evaluate disease severity, and support prognosis. A combination plasma biomarkers brief digital cognitive assessments could provide a scalable alternative current work‐up. METHODS We examined the accuracy 10‐minute supervised tablet‐based assessment (Tablet‐based Cognitive Assessment Tool Brain Health [TabCAT‐BHA]) in predicting amyloid β...
Background:Little is known about the distribution of medical comorbidities in Alzheimer's disease (AD). Objective:We aimed to describe comorbidity pattern AD a nested case-control study. Methods:Incident cases were identified by International Classification Diseases codes rando m sample 2 million individuals Taiwan National Health Insurance program during 2001–2011. We further restricted those treated with drugs approved reimbursement. sampled set age- and sex-matched control subjects (2:1...
Although numerous epidemiological studies revealed an association between ambient fine particulate matter (PM 2.5 ) exposure and Alzheimer’s disease (AD), the PM -induced neuron toxicity associated mechanisms were not fully elucidated. The present study assessed brain in 6-month-old female triple-transgenic AD (3xTg-AD) mice following subchronic to via inhalation system. treated whole-bodily continuously exposed real-world for 3 months, while control inhaled filtered air. Changes cognitive...
Abstract Frontotemporal dementia (FTD) is one of the leading causes before age 65 and often manifests as abnormal behavior (in behavioral variant FTD) or language impairment primary progressive aphasia). FTD's exact clinical presentation varies by culture, language, education, social norms, other socioeconomic factors; current research practice, however, mainly based on studies conducted in North America Western Europe. Changes diagnostic criteria procedures well new adapted cognitive tests...
Abstract The non-fluent/agrammatic variant of primary progressive aphasia (nfvPPA) is a neurodegenerative syndrome primarily defined by the presence apraxia speech (AoS) and/or expressive agrammatism. In addition, many patients exhibit dysarthria receptive This leads to substantial phenotypic variation within speech-language domain across individuals and time, in terms both specific combination symptoms as well their severity. How resolve such heterogeneity nfvPPA matter debate. ‘Splitting’...
Abstract INTRODUCTION Clinical understanding of primary progressive aphasia (PPA) has been primarily derived from Indo‐European languages. Generalizing certain linguistic findings across languages is unfitting due to contrasting structures. While PPA patients showed noun classes impairments, Chinese lack classes. Instead, are classifier language, and how manipulate classifiers unknown. METHODS We included 74 native speakers (22 controls, 52 PPA). For production task, participants were asked...
Frontotemporal dementia (FTD) includes behavioral-variant FTD (bvFTD) with predominant frontal atrophy and semantic (sbvFTD) right anterior temporal lobe (rATL) atrophy. These variants present diagnostic challenges because of overlapping symptoms neuroanatomy. Accurate differentiation is crucial for clinical trial inclusion targeting TDP-43 proteinopathies. This study investigated whether automated speech analysis can distinguish between FTD-related rATL atrophy, potentially offering a...
Background Primary progressive aphasia (PPA) is a neurodegenerative syndrome that impairs language and speech abilities. Limited research exists on PPA in Indonesia, understanding neurologists’ perspectives crucial for improving early diagnosis management. Objective This study aimed to assess Indonesian knowledge, attitudes, practices regarding PPA. Methods neurologists were invited complete an online questionnaire covering demographics, clinical experiences, of variants treatments,...
<h3>Background and Objectives</h3> Most primary progressive aphasia (PPA) literature is based on English language users. Linguistic features that vary from English, such as logographic writing systems, are underinvestigated. The current study characterized the dysgraphia phenotypes of patients with PPA who write in Chinese investigated their diagnostic utility classifying variants. <h3>Methods</h3> This recruited 40 participants 20 cognitively normal San Francisco, Hong Kong, Taiwan. We...
Despite a high rate of concurrent mathematical difficulties among children with dyslexia, we still have limited information regarding the prevalence and severity deficits in this population. To address gap, developed comprehensive battery cognitive tests, known as UCSF Mathematical Cognition Battery (MCB), aim identifying four distinct domains: number processing, arithmetical procedures, arithmetic facts retrieval, geometrical abilities. The abilities cohort 75 referred to Dyslexia Center...
Abstract Background Air pollution, especially fine particulate matter (PM), can cause brain damage, cognitive decline, and an increased risk of neurodegenerative disease, alzheimer’s disease (AD). Typical pathological findings amyloid tau protein accumulation have been detected in the after exposure animal studies. However, these observations were based on high levels PM exposure, which far from WHO guidelines those present our environment. In addition, white involvement by air pollution has...
Abstract Underserved and underrepresented populations have historically been excluded from neurological research. This lack of representation has implications for translation research findings into clinical practice given the impact social determinants health on disease risk, progression, outcomes. Lack inclusion in is driven by individual-, investigator-, study-level barriers as well larger systemic injustices (e.g., structural racism, discriminatory practices). Although strategies to...
Abstract Developmental dyslexia is typically associated with difficulties in basic auditory processing and manipulating speech sounds. However, the neuroanatomical correlates of developmental (DD) their contribution to individual clinical phenotypes are still unknown. Recent intracranial electrocorticography findings sound amplitude rises sounds posterior middle superior temporal gyrus (STG), respectively. We hypothesize that regional STG anatomy will relate specific abilities DD, behavioral...
The significant increase in Alzheimer's disease and related dementia prevalence is a global health crisis, acutely impacting low- lower-middle upper-middle-income countries (LLMICs/UMICs).
Clinical phenotyping of primary progressive aphasia has largely focused on speech and language presentations, leaving other cognitive domains under-examined. This study investigated the diagnostic utility visuospatial profiles examined their neural basis among three main variants. We studied neuropsychological performances 118 participants 30 cognitively normal controls, across 11 measures cognition, correlates via voxel-based morphometry analysis using composite scores derived from...
Abstract It is debated whether primary progressive apraxia of speech (PPAOS) and agrammatic aphasia (PAA) belong to the same clinical spectrum, traditionally termed non-fluent/agrammatic variant (nfvPPA), or exist as two completely distinct syndromic entities with specific pathologic/prognostic correlates. We analysed speech, language disease severity features in a comprehensive cohort patients motor impairment and/or agrammatism ascertain evidence naturally occurring, clinically meaningful...
Clinical understanding of primary progressive aphasia (PPA) has been established based on English-speaking population. The lack linguistic diversity in research hinders the diagnosis PPA non-English speaking patients. This case report describes tonal and orthographic deficits a multilingual native Cantonese-speaking woman with nonfluent/agrammatic variant (nfvPPA) supranuclear palsy. Our findings suggest that nfvPPA patients exhibit tone production impairments, perception at lexical...