A5064791227- Alzheimer's disease research and treatments
- Tryptophan and brain disorders
- Nerve injury and regeneration
- Cholinesterase and Neurodegenerative Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Cholesterol and Lipid Metabolism
- Dementia and Cognitive Impairment Research
- Health, Environment, Cognitive Aging
- RNA Research and Splicing
- Drug Transport and Resistance Mechanisms
- interferon and immune responses
- 14-3-3 protein interactions
- Diet and metabolism studies
- Epigenetics and DNA Methylation
- Functional Brain Connectivity Studies
- Neuroscience and Neuropharmacology Research
- Protease and Inhibitor Mechanisms
- Molecular Biology Techniques and Applications
- Amino Acid Enzymes and Metabolism
- Neonatal and fetal brain pathology
- Nuclear Receptors and Signaling
- Pain Management and Opioid Use
- Chemokine receptors and signaling
- Nicotinic Acetylcholine Receptors Study
- Retinoids in leukemia and cellular processes
Universidad Católica de Cuyo
2010-2024
Centro Científico Tecnológico - San Juan
2010-2024
McGill University
2006-2024
Consejo Nacional de Investigaciones Científicas y Técnicas
2010-2021
Therapeutics Clinical Research
2004
In this report, we provide direct demonstration that the neurotrophin nerve growth factor (NGF) is released in extracellular space an activity-dependent manner its precursor form (proNGF) and it compartment maturation degradation takes place because of coordinated release action proenzymes enzyme regulators. This converting protease cascade endogenous regulators (including tissue plasminogen activator, plasminogen, neuroserpin, matrix metalloproteinase 9, inhibitor 1) are colocalized neurons...
Abstract Brain clocks, which quantify discrepancies between brain age and chronological age, hold promise for understanding health disease. However, the impact of diversity (including geographical, socioeconomic, sociodemographic, sex neurodegeneration) on brain-age gap is unknown. We analyzed datasets from 5,306 participants across 15 countries (7 Latin American Caribbean (LAC) 8 non-LAC countries). Based higher-order interactions, we developed a deep learning architecture functional...
Nerve growth factor (NGF)-dependent cholinergic basal forebrain neurons degenerate during the progression of Alzheimer disease (AD). Elevated proNGF and reduced levels TrkA high-affinity NGF receptor occur in prodromal advanced stages AD. We recently described a protease cascade responsible for conversion to mature (mNGF) which matrix metalloproteinase 9 (MMP-9) degrades mNGF extracellular space. To determine whether this proteolytic is altered AD, we examined human frontal parietal cortex...
We previously reported that the precursor form of nerve growth factor (pro-NGF) and not mature NGF is liberated in CNS an activity-dependent manner, its maturation degradation occur extracellular space by coordinated action proteases.Here, we present evidence diminished conversion pro-NGF to greater Alzheimer disease (AD) brain samples compared with controls. These alterations metabolic pathway likely resulted increased levels. The was largely a peroxynitrited AD samples. Intrahippocampal...
Abstract BACKGROUND Education influences brain health and dementia. However, its impact across regions, specifically Latin America (LA) the United States (US), is unknown. METHODS A total of 1412 participants comprising controls, patients with Alzheimer's disease (AD), frontotemporal lobar degeneration (FTLD) from LA US were included. We studied association education volume functional connectivity while controlling for imaging quality variability, age, sex, intracranial (TIV), recording...
Cortical cholinergic atrophy plays a significant role in the cognitive loss seen with aging and Alzheimer's disease (AD), but mechanisms leading to it remain unresolved. Nerve growth factor (NGF) is neurotrophin responsible for phenotypic maintenance of basal forebrain neurons mature fully differentiated CNS. In consequence, its implication has been suspected; however, no mechanistic explanation provided. We have previously shown that precursor NGF (proNGF) cleaved extracellularly by plasmin...
The standard model of system consolidation proposes that memories are initially hippocampus dependent and become independent over time. Previous studies have demonstrated the involvement medial prefrontal cortex (mPFC) in retrieval remote memories. transformations required to make a memory undergo system's thought require synaptic plasticity. In this study, we investigated participation mitogen-activated protein kinase (MAPK)/ERK pathway acquisition, consolidation, recent recall Morris water...
Previously, we developed a proteolytically stable small molecule peptidomimetic termed D3 as selective ligand of the extracellular domain TrkA receptor for NGF. Ex vivo was defined selective, partial agonist. Here, in efficacy potential therapeutic cholinergic neurons tested cognitively impaired aged rats, and compared consequence activation (D3) versus full TrkA/p75 (NGF). We show that binds to receptors affords significant long-lived phenotypic rescue phenotype both cortex nucleus basalis....
<i>Background:</i> Intracellular accumulation of β-amyloid (Aβ) is one the early features in neuropathology Alzheimer’s disease (AD) and Down’s syndrome. This can be reproduced cell transgenic animal models AD-like amyloid pathology. In a rat model, our lab has previously shown that intracellular Aβ sufficient to provoke cognitive impairments biochemical alterations cerebral cortex hippocampus absence plaques. <i>Objective:</i> To investigate an early, pre-plaque...
The progressive accumulation of amyloid-beta (Aβ) in specific areas the brain is a common prelude to late-onset Alzheimer's disease (AD). Although activation liver X receptors (LXR) with agonists decreases Aβ levels and ameliorates contextual memory deficit, concomitant hypercholesterolemia/hypertriglyceridemia limits their clinical application. DMHCA (N,N-dimethyl-3β-hydroxycholenamide) an LXR partial agonist that, despite inducing expression apolipoprotein E (main responsible drainage from...
Abstract Ocular and periocular traumatisms may result in loss of vision. Hypothermia provides a beneficial intervention for brain heart conditions and, here, we study whether hypothermia can prevent retinal damage caused by traumatic neuropathy. Intraorbital optic nerve crush (IONC) or sham manipulation was applied to male rats. Some animals were subjected (8 °C) 3 h following surgery. Thirty days later, electroretinography behavioral tests. IONC treatment resulted amplitude reduction the...
<title>Abstract</title> Brain clocks, which quantify discrepancies between brain age and chronological age, hold promise for understanding health disease. However, the impact of multimodal diversity (geographical, socioeconomic, sociodemographic, sex, neurodegeneration) on gap (BAG) is unknown. Here, we analyzed datasets from 5,306 participants across 15 countries (7 Latin American -LAC, 8 non-LAC). Based higher-order interactions in signals, developed a BAG deep learning architecture...
Real-time reverse transcription PCR (qPCR) normalized to an internal reference gene (RG), is a frequently used method for quantifying expression changes in neuroscience. Although RG assumed be constant independent of physiological or experimental conditions, several studies have shown that commonly RGs are not expressed stably. The use unstable has profound effect on the conclusions drawn from expression, and almost universally results spurious estimation target expression. Approaches aimed...
Abstract Background Predicting Alzheimer's disease (AD) and frontotemporal dementia (FTD) using polygenic risk scores (PRS) for late‐onset forms holds promise, but its accuracy might be influenced by social determinants of health (SDOH). This study explores how considering SDOH alongside genes can improve prediction, focusing on potential differences each disease. Methods Employing logistic regression in 677 individuals (287 AD, 102 FTD, 288 controls) aged 40‐80 from the ReDLat across six...
Abstract Background Chronic pain (CP) is defined as the persistence of beyond expected recovery period an injury, or alternatively, with a duration exceeding three months. It has been recognized risk factor for dementia in European and North American cohorts . However, Latin America (LA), there remains significant gap understanding CP prevalence, its factors, association Alzheimer’s disease (AD) frontotemporal (FTD). Our study aims to shed light on impact LA population, along implications AD...