A5002661716- Neurobiology of Language and Bilingualism
- Functional Brain Connectivity Studies
- Action Observation and Synchronization
- EEG and Brain-Computer Interfaces
- Dementia and Cognitive Impairment Research
- Health, Environment, Cognitive Aging
- Neural dynamics and brain function
- Reproductive biology and impacts on aquatic species
- Autism Spectrum Disorder Research
- Language, Metaphor, and Cognition
- Neural and Behavioral Psychology Studies
- Psychosomatic Disorders and Their Treatments
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Aquaculture Nutrition and Growth
- Transcranial Magnetic Stimulation Studies
- Animal Behavior and Reproduction
- Memory and Neural Mechanisms
- Child and Animal Learning Development
- Genetic Neurodegenerative Diseases
- Epilepsy research and treatment
- Motor Control and Adaptation
- Advanced Neuroimaging Techniques and Applications
- Neurology and Historical Studies
- Multisensory perception and integration
- Face Recognition and Perception
Universidad de La Laguna
2023-2024
Centro Científico Tecnológico - San Juan
2017-2024
University of San Andrés
2020-2024
Consejo Nacional de Investigaciones Científicas y Técnicas
2016-2024
Universidad Nacional de Córdoba
2020-2024
Adolfo Ibáñez University
2020-2024
Instituto de Neurología Cognitiva
2016-2022
Favaloro University
2016-2020
Universidad Nacional de Cuyo
2020
Universidad de Santiago de Chile
2020
Abstract Brain clocks, which quantify discrepancies between brain age and chronological age, hold promise for understanding health disease. However, the impact of diversity (including geographical, socioeconomic, sociodemographic, sex neurodegeneration) on brain-age gap is unknown. We analyzed datasets from 5,306 participants across 15 countries (7 Latin American Caribbean (LAC) 8 non-LAC countries). Based higher-order interactions, we developed a deep learning architecture functional...
Recursive social decision-making requires the use of flexible, context-sensitive long-term strategies for negotiation. To succeed in bargaining, participants' own perspectives must be dynamically integrated with those interactors to maximize self-benefits and adapt other's preferences, respectively. This is a prerequisite develop successful self-other integration strategy. While such form strategic interaction critical decision-making, little known about its neurocognitive correlates. bridge...
Recent frameworks in cognitive neuroscience and behavioral neurology underscore interoceptive priors as core modulators of negative emotions. However, the field lacks experimental designs manipulating priming emotions via interoception exploring their multimodal signatures neurodegenerative models. Here, we designed a novel task that involves control-exteroceptive conditions followed by post-interoception post-exteroception facial emotion recognition (FER). We recruited 114 participants,...
Interoception (the sensing of inner-body signals) is a multi-faceted construct with major relevance for basic and clinical neuroscience research. However, the neurocognitive signatures this domain (cutting across behavioral, electrophysiological, fMRI connectivity levels) are rarely reported in convergent or systematic fashion. Additionally, various controversies field might reflect caveats standard interoceptive accuracy (IA) indexes, mainly based on heartbeat detection (HBD) tasks. Here we...
The predictive coding theory of allostatic-interoceptive load states that brain networks mediating autonomic regulation and interoceptive-exteroceptive balance regulate the internal milieu to anticipate future needs environmental demands. These functions seem be distinctly compromised in behavioral variant frontotemporal dementia (bvFTD), including alterations network (AIN). Here, we hypothesize bvFTD is typified by an overload.
Brain functional connectivity in dementia has been assessed with dissimilar EEG metrics and estimation procedures, thereby increasing results' heterogeneity. In this scenario, joint analyses integrating information from different may allow for a more comprehensive characterization of brain interactions subtypes. To test hypothesis, resting-state electroencephalogram (rsEEG) was recorded individuals Alzheimer's Disease (AD), behavioral variant frontotemporal (bvFTD), healthy controls (HCs)....
Diversity in brain health is influenced by individual differences demographics and cognition. However, most studies on diseases have typically controlled for these factors rather than explored their potential to predict signals. Here, we assessed the role of (age, sex, education; n = 1,298) cognition (n 725) as predictors different metrics usually used case-control studies. These included power spectrum aperiodic (1/f slope, knee, offset) metrics, well complexity (fractal dimension...
Abstract Objective. The differential diagnosis of behavioral variant frontotemporal dementia (bvFTD) and Alzheimer’s disease (AD) remains challenging in underrepresented, underdiagnosed groups, including Latinos, as advanced biomarkers are rarely available. Recent guidelines for the study highlight critical role biomarkers. Thus, novel cost-effective complementary approaches required clinical settings. Approach . We developed a framework based on gradient boosting machine learning...
Abstract The Latin American Brain Health Institute (BrainLat) has released a unique multimodal neuroimaging dataset of 780 participants from American. includes 530 patients with neurodegenerative diseases such as Alzheimer’s disease (AD), behavioral variant frontotemporal dementia (bvFTD), multiple sclerosis (MS), Parkinson’s (PD), and 250 healthy controls (HCs). This (62.7 ± 9.5 years, age range 21–89 years) was collected through multicentric effort across five countries to address the need...
Harmonization protocols that address batch effects and cross-site methodological differences in multi-center studies are critical for strengthening electroencephalography (EEG) signatures of functional connectivity (FC) as potential dementia biomarkers.We implemented an automatic processing pipeline incorporating electrode layout integrations, patient-control normalizations, multi-metric EEG source space connectomics analyses.Spline interpolations signals onto a head mesh model with 6067...
This study examined whether systematic whole-body stimulation and increased attention to visuospatial motion patterns can enhance the appraisal of action meanings evoked by naturalistic texts. Participants listened neutral (non-action) narratives before after videogame-based bodily training, responded questions on information realized verbs (denoting abstract processes) circumstances (conveying locative or temporal details, for example). Strategically, we worked with dyslexic children, whose...
Do embodied semantic systems play different roles depending on when and how well a given language was learned? Emergent evidence suggests that this is the case for isolated, decontextualized stimuli, but no study has addressed issue considering naturalistic narratives. Seeking to bridge gap, we assessed motor-system dynamics in 26 Spanish-English bilinguals as they engaged free, unconstrained reading of action texts (ATs, highlighting characters' movements) neutral (NTs, featuring low...
Abstract An accruing body of research has shown that interoception (the sensing signals from the body's internal milieu) relies on both a direct route (afforded by vagus nerve) and secondary (supported somatosensory mechanisms). However, no study causally tested differential role these pathways, let alone via stimulation. To bridge this gap, we whether multidimensional signatures are modulated noninvasive nerve stimulation (nVNS). Sixty‐three participants were divided into an nVNS...
Social feedback can selectively enhance learning in diverse domains. Relevant neurocognitive mechanisms have been studied mainly healthy persons, yielding correlational findings. Neurodegenerative lesion models, coupled with multimodal brain measures, complement standard approaches by revealing direct multidimensional correlates of the phenomenon. To this end, we assessed socially reinforced and non-socially 40 participants as well persons behavioural variant frontotemporal dementia (n =...
Abstract Neurodegeneration has multiscalar impacts, including behavioral, neuroanatomical, and neurofunctional disruptions. Can disease-differential alterations be captured across such dimensions using naturalistic stimuli? To address this question, we assessed comprehension of four stories, highlighting action, nonaction, social, nonsocial events, in Parkinson’s disease (PD) behavioral variant frontotemporal dementia (bvFTD) relative to Alzheimer’s patients healthy controls. Text-specific...
ABSTRACT Objective Neurological nosology, based on categorical systems, has largely ignored dimensional aspects of neurocognitive impairments. Transdiagnostic approaches interoception (the sensing visceral signals) may improve the descriptions cross-pathological symptoms at behavioral, electrophysiological, and anatomical levels. Alterations cardiac (encompassing multidimensional variables such as accuracy, learning, sensibility, awareness) its neural correlates (electrophysiological...
Abstract INTRODUCTION Verbal fluency tasks are common in Alzheimer's disease (AD) assessments. Yet, standard valid response counts fail to reveal disease‐specific semantic memory patterns. Here, we leveraged automated word‐property analysis capture neurocognitive markers of AD vis‐à‐vis behavioral variant frontotemporal dementia (bvFTD). METHODS Patients and healthy controls completed two tasks. We counted responses computed each word's frequency, granularity, neighborhood, length,...
Abstract In construing meaning, the brain recruits multimodal (conceptual) systems and embodied (modality-specific) mechanisms. Yet, no consensus exists on how crucial latter are for inception of semantic distinctions. To address this issue, we combined electroencephalographic (EEG) intracranial EEG (iEEG) to examine when nouns denoting facial body parts (FBPs) nonFBPs discriminated in face-processing networks. First, FBP words increased N170 amplitude (a hallmark early processing). Second,...
The pressing call to detect sensitive cognitive markers of frontal lobe epilepsy (FLE) remains poorly addressed. Standard frameworks prove nosologically unspecific (as they reveal deficits that also emerge across other subtypes), possess low ecological validity, and are rarely supported by multimodal neuroimaging assessments. To bridge these gaps, we examined naturalistic action non-action text comprehension, combined with structural functional connectivity measures, in 19 FLE patients,...