A5004382569- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Viral Infectious Diseases and Gene Expression in Insects
- Neuroinflammation and Neurodegeneration Mechanisms
- Neural dynamics and brain function
- Memory Processes and Influences
- Sleep and Wakefulness Research
- Insect Resistance and Genetics
- Receptor Mechanisms and Signaling
- Action Observation and Synchronization
- Neuroendocrine regulation and behavior
- Virtual Reality Applications and Impacts
- Retinal Development and Disorders
- Stress Responses and Cortisol
- Traumatic Brain Injury Research
- Nerve injury and regeneration
- Neurobiology and Insect Physiology Research
- Motor Control and Adaptation
- CRISPR and Genetic Engineering
- Diabetes Management and Education
- Circadian rhythm and melatonin
- Chemical and Physical Properties in Aqueous Solutions
- Protein purification and stability
- Nursing care and research
- Developmental and Educational Neuropsychology
Consejo Nacional de Investigaciones Científicas y Técnicas
2012-2024
Favaloro University
2017-2024
Instituto de Neurología Cognitiva
2017-2024
Université de Montpellier
2021-2024
Centre National de la Recherche Scientifique
2023-2024
Inserm
2021-2024
Institut de Génomique Fonctionnelle
2021-2023
Fundación Instituto Leloir
2022
Centro Científico Tecnológico - San Juan
2021
University of Buenos Aires
2009-2019
Recent frameworks in cognitive neuroscience and behavioral neurology underscore interoceptive priors as core modulators of negative emotions. However, the field lacks experimental designs manipulating priming emotions via interoception exploring their multimodal signatures neurodegenerative models. Here, we designed a novel task that involves control-exteroceptive conditions followed by post-interoception post-exteroception facial emotion recognition (FER). We recruited 114 participants,...
Context-dependent memories may guide adaptive behavior relaying in previous experience while updating stored information through reconsolidation. Retrieval can be triggered by partial and shared cues. When the cue is presented, most relevant memory should updated. In a contextual version of object recognition task, we examined effect medial PFC (mPFC) serotonin 2a receptor (5-HT2aR) blockade during retrieval reconsolidation competing objects memories. We found that mPFC 5-HT2aR controls...
Successful memory involves not only remembering over time but also keeping memories distinct. The ability to separate similar experiences into distinct is a main feature of episodic memory. Discrimination overlapping representations has been investigated in the dentate gyrus hippocampus (DG), little known about this process other regions such as perirhinal cortex (Prh). We found male rats that brain-derived neurotrophic factor (BDNF) required for separable storage overlapping, distinct,...
The ability to separate similar experiences into differentiated representations is proposed be based on a computational process called pattern separation, and it one of the key characteristics episodic memory. Although separation has been mainly studied in dentate gyrus hippocampus, this cognitive function if thought take place also other regions brain. perirhinal cortex important for acquisition storage object memories, particular memory differentiation. present study was devoted...
<h3>INTRODUCTION</h3> An intronic germline mutation in the <i>MSH2</i> gene, A→T at nt942+3, interferes with exon 5 donor splicing mechanism leading to a mRNA lacking 5. This causes typical hereditary non-polyposis colorectal cancer (HNPCC) and has been observed numerous probands families world wide. Recurrent mutations either arise repeatedly de novo or emanate from ancestral founding mutational events. The had previously shown be enriched population of Newfoundland where most shared...
Changes in memory performance are one of the main symptoms normal aging. The storage similar experiences as different memories (ie. behavioral pattern separation), becomes less efficient aging progresses. Studies have focused on hippocampus dependent spatial and their role related deficits separation (BPS) by targeting high similarity interference conditions. However, parahippocampal cortices such perirhinal cortex also particularly vulnerable to Middle age is thought be stage where mild...
Abstract Differentiating between similar memories is a crucial cognitive function that enables correct episodic memory formation. The ability to separate the components of into distinct representations thought rely on computational process known as pattern separation, by which differences are amplified disambiguate events. Although separation has been localized dentate gyrus (DG) hippocampus and shown occur in spatial domain, this takes place also during processing other types information....
Associative learning provides a mean to learn appropriate valence and salience value signals that animal can later use make value-based choices. By generalizing from prior aversive experience comparing motivational current one, animals the relative (better or worse than) positive safety between experiences. Yet, how such are acquired during remain poorly known. The paraventricular nucleus of thalamus (PVT) is critical for control signals, therefore it well-placed be involved in learned...
Episodic memory is essential to navigate in a changing environment by recalling past events, creating new memories, and updating stored information from experience. Although the mechanisms for acquisition consolidation have been profoundly studied, much less known about retrieval. Hippocampal spatial representations are key retrieval of contextually guided episodic memories. Indeed, hippocampal place cells exhibit stable location-specific activity which thought support contextual memory, but...
Physical activity benefits both fitness and cognition. However, its effect on long-term memory is unclear. In this study, we evaluated the of acute chronic exercise spatial for a new virtual reality task. Participants were immersed in environment navigated wide arena that included target objects. We assessed two conditions (encoded targets separated by short or long distance) found 25 min cycling after encoding - but not before retrieval was sufficient to improve retention short, distance....
Abstract Active forgetting occurs in many species, but how the mechanisms that control behavior contribute to determining which memories are forgotten is still unknown. We previously found when rats need retrieve particular guide exploration, it reduces later retention of other encoded environment. As with humans, this retrieval-induced relies on prefrontal processes. The dopaminergic input cortex important for executive functions and cognitive flexibility. that, a similar way, dopamine...
A process of directed evolution applied to obtain a library mutants horseradish peroxidase (HRP) enzyme is described. We have introduced slight variations into the original DNA shuffling protocol. template was prepared by PCR amplification and digested with Dnase I during 1 hour. products were concentrated precipitation isopropanol. Gel electrophoresis showed fragments desired size range (20-600 pb) without full-length remaining in reaction mixture. high concentration crucial for performing...