A5019442615- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Receptor Mechanisms and Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Stress Responses and Cortisol
- Neurogenesis and neuroplasticity mechanisms
- Neurotransmitter Receptor Influence on Behavior
- Nicotinic Acetylcholine Receptors Study
- Sleep and Wakefulness Research
- Anesthesia and Neurotoxicity Research
- Genetics and Neurodevelopmental Disorders
- Neuropeptides and Animal Physiology
- Cholinesterase and Neurodegenerative Diseases
- Biochemical effects in animals
- Biochemical Analysis and Sensing Techniques
- Zebrafish Biomedical Research Applications
- Neuroendocrine regulation and behavior
- Ion channel regulation and function
- Phosphodiesterase function and regulation
- Nerve injury and regeneration
- Memory Processes and Influences
- Epilepsy research and treatment
- Synthesis and pharmacology of benzodiazepine derivatives
- Medicinal Plant Extracts Effects
- Photochromic and Fluorescence Chemistry
Institute for Cross-Disciplinary Physics and Complex Systems
2025
University of Buenos Aires
2014-2024
Buenos Aires Institute of Technology
2021-2024
Consejo Nacional de Investigaciones Científicas y Técnicas
2014-2024
National Polytechnic School
2022-2024
Instituto de Biología Molecular y Celular de Rosario
1989-2022
Experimental Medicine and Biology Institute
2022
Texas Woman's University
2021
Institute of Astronomy and Space Physics
2014-2020
Universidade Federal do Rio Grande do Norte
2015
Persistence is a characteristic attribute of long-term memories (LTMs). However, little known about the molecular mechanisms that mediate this process. We recently showed persistence LTM requires late protein synthesis- and BDNF-dependent phase in hippocampus. Here, we show intrahippocampal delivery BDNF reverses deficit memory caused by inhibition hippocampal synthesis. Importantly, demonstrate induces itself, transforming nonlasting trace into persistent one an ERK-dependent manner. Thus,...
cAMP/cAMP-dependent protein kinase (PKA) signaling pathway has been recently proposed to participate in both the late phase of long term potentiation hippocampus and late, synthesis-dependent memory formation. Here we report that a consolidation an inhibitory avoidance learning is regulated by hippocampal cAMP activated, at least part, D 1 /D 5 receptors. Bilateral infusion SKF 38393 (7.5 μg/side), receptor agonist, into CA region dorsal hippocampus, enhanced retention step-down when given 3...
The paradigmatic feature of long-term memory (LTM) is its persistence. However, little known about the mechanisms that make some LTMs last longer than others. In rats, a long-lasting fear LTM vanished rapidly when D1 dopamine receptor antagonist SCH23390 was injected into dorsal hippocampus 12 hours, but not immediately or 9 after fearful experience. Conversely, intrahippocampal application agonist SK38393 at same critical post-training time converted decaying persistent one. This effect...
Brain-derived neurotrophic factor (BDNF) is a potent modulator of synaptic transmission and plasticity in the CNS, acting both pre- postsynaptically. We demonstrated recently that BDNF/TrkB signaling increases dendritic spine density hippocampal CA1 pyramidal neurons. Here, we tested whether activation prominent ERK (MAPK) pathway was responsible for BDNF's effects on growth. Slice cultures were transfected with enhanced yellow fluorescent protein (eYFP) by particle-mediated gene transfer,...
Abstract Information storage in the brain is a temporally graded process involving different memory types or phases. It has been assumed for over century that one more short‐term (STM) processes are involved processing new information while long‐term (LTM) being formed. Because brain‐derived neutrophic factor (BDNF) modulates both synaptic function and activity‐dependent plasticity adult hippocampus, we examined role of BDNF STM LTM formation hippocampal‐dependent one‐trial fear‐motivated...
Abstract The hippocampus and amygdala, the entorhinal cortex parietal participate, in that sequence, both formation expression of memory for a step‐down inhibitory avoidance task rats. Bilateral infusion AP5 or muscimol caused retrograde amnesia when given O min after training into 180 cortex, cortex. Therefore, requires sequential integrated activity all these areas mediated by glutamate NMDA receptors each case. Pre‐test administration CNQX 1 day 31 days 1, 60 temporarily blocked retention...
Information storage in the brain is a temporally graded process involving different memory types or phases. It has been assumed for over century that one more short-term (STM) processes are involved processing new information while long-term (LTM) being formed. repeatedly reported LTM requires<i>de novo</i> RNA synthesis around time of training. Here we show formation one-trial inhibitory avoidance training rats, hippocampal-dependent form contextual fear conditioning, depends on two...
Evidence that protein synthesis inhibitors induce amnesia in a variety of species and learning paradigms indicates the consolidation newly acquired information into stable memories requires new proteins. Because extinction response also acquisition information, extinction, like original learning, would be expected to require synthesis. The present experiments examined involvement hippocampus learned fear-based known involve hippocampus. Rats were trained one-trial inhibitory avoidance task...
Long-term habituation to a novel environment is one of the most elementary forms nonassociative learning. Here we studied effect pre- or posttraining intrahippocampal administration drugs acting on specific molecular targets retention 5-min exposure an open field measured 24 h later. We also determined whether resulted in activation same intracellular signaling cascades previously shown be activated during hippocampal-dependent associative The immediate bilateral infusion CNQX (1 μg/side),...
Upon retrieval, consolidated memories are again rendered vulnerable to the action of metabolic blockers, notably protein synthesis inhibitors. This has led hypothesis that reconsolidated at time and this depends on synthesis. Ample evidence indicates hippocampus plays a key role both in consolidation reconsolidation different memories. Despite fact, present there no studies about consequences hippocampal inhibition storage post-retrieval persistence object recognition memory. Here we report...
The mammalian target of Rapamycin (mTOR) kinase plays a key role in translational control subset mRNAs through regulation its initiation step. In neurons, mTOR is present at the synaptic region, where it modulates activity-dependent expression locally-translated proteins independently mRNA synthesis. Indeed, necessary for different forms plasticity and long-term memory (LTM) formation. However, little known about time course activation extracellular signals governing this process or identity...
Pavlovian conditioning involves the association of initially neutral conditioned stimuli (CS) with unconditioned (US) that elicit a response. In contextual fear in rodents, CS is context training apparatus and US foot shock. Retrieval memory tested by presenting alone. But retrieval test also initiates extinction That is, presentation alone results new learning, i.e., no longer predicts US. Here we report triggered two hippocampal signaling pathways underlying (the cAMP-dependent protein...
Abstract It has been recently demonstrated that ubiquitin–proteasome‐mediated proteolysis is required for long‐term synaptic facilitation in Aplysia. Here we show the hippocampal blockade of this proteolytic pathway also formation memory rat. Bilateral infusion lactacystin, a specific proteasome inhibitor, to CA1 region caused full retrograde amnesia one‐trial inhibitory avoidance learning when given 1, 4 or 7h, but not 10 h, after training. Proteasome inhibitor I produced similar effects....