Persistence is a characteristic attribute of long-term memories (LTMs). However, little known about the molecular mechanisms that mediate this process. We recently showed persistence LTM requires late protein synthesis- and BDNF-dependent phase in hippocampus. Here, we show intrahippocampal delivery BDNF reverses deficit memory caused by inhibition hippocampal synthesis. Importantly, demonstrate induces itself, transforming nonlasting trace into persistent one an ERK-dependent manner. Thus,...

The mammalian target of Rapamycin (mTOR) kinase plays a key role in translational control subset mRNAs through regulation its initiation step. In neurons, mTOR is present at the synaptic region, where it modulates activity-dependent expression locally-translated proteins independently mRNA synthesis. Indeed, necessary for different forms plasticity and long-term memory (LTM) formation. However, little known about time course activation extracellular signals governing this process or identity...

Memory formation is a temporally graded process during which transcription and translation steps are required in the first hours after acquisition. Although persistence key characteristic of memory storage, its mechanisms scarcely characterized. Here, we show that long-lasting but not short-lived inhibitory avoidance long-term associated with delayed expression c-Fos hippocampus. Importantly, this late wave necessary for maintenance storage. Moreover, inhibition dorsal hippocampus 24 h...

The retrosplenial cortex (RSC) is involved in a range of cognitive functions. However, its precise involvement memory processing unknown. Pharmacological and behavioral experiments demonstrate that protein synthesis c-Fos expression the anterior part RSC (aRSC) are necessary late after training to maintain for many days fear-motivated memory. Long-lasting storage regulated by D1/D5 dopamine receptors aRSC depends on functional interplay between dorsal hippocampus aRSC. These results suggest...

Abstract The retrosplenial cortex (RSC) is implicated on navigation and contextual memory. Lesions studies showed that the RSC shares functional similarities with hippocampus (HP). Here we evaluated role of anterior (aRSC) in “what” “where” components recognition memory contrasted it dorsal HP (dHP). Our behavioral molecular findings show differences between aRSC dHP inactivation aRSC, but not dHP, impairs consolidation expression component. In addition, object task accompanied by c-Fos...

Memory storage is a temporally graded process involving different phases and structures in the mammalian brain. Cortical plasticity essential to store stable memories, but little known regarding its involvement memory processing. Here we show that fear consolidation requires early post-training macromolecular synthesis anterior part of retrosplenial cortex (aRSC), reversible pharmacological inactivation this cortical region impairs recall recent as well remote memories. These results...

Medial prefrontal cortex (mPFC) is essential for initial memory processing and expression but its involvement in persistent storage has seldom been studied. Using the hippocampus dependent inhibitory avoidance learning task hippocampus-independent conditioned taste aversion paradigm together with specific dopamine receptor agonists antagonists we found that persistence not formation of long-tem aversive memories requires D1/D5 receptors activation mPFC immediately after training and,...

During the past few years, there has been growing interest in role of retrosplenial cortex (RSC) memory processing. However, little is known about molecular changes that take place this brain region during formation. In present work, we studied early post-training participation RSC formation a long-lasting rats. We found an increase c-Fos levels anterior part (aRSC) after inhibitory avoidance (IA) training. Interestingly, was associated with durability, since blocking expression using...

Understanding how stored information emerges is a main question in the neurobiology of memory that now increasingly gaining attention. However, molecular events underlying this stage, including involvement protein synthesis, are not well defined. Mammalian target rapamycin complex 1 (mTORC1), central regulator has been implicated synaptic plasticity and required for formation. Using inhibitory avoidance (IA), we evaluated role mTORC1 retrieval. Infusion selective inhibitor, rapamycin, into...

The synaptic tagging and capture (STC) hypothesis provides a compelling explanation for specificity facilitation of long-term potentiation. Its implication on memory (LTM) formation led to postulate the behavioral mechanism. Here we show that maintenance process may operate in hippocampus late after acquisition persistence long-lasting storage. proposed has several characteristics: (1) tag is transient time-dependent; (2) it sets critical time window an aversive training which induces...

Abstract Learning to avoid threats in the environment is highly adaptive. However, sometimes a dysregulation of fear memories processing may underlie fear-related disorders. Despite recent advances, major question how effectively attenuate persistent safe manner remains unresolved. Here we show experiments employing behavioural tool target specific time window after training limit persistence memory rats. We observed that exposure novel 11 h an inhibitory avoidance (IA) induces long-lasting...

The retrosplenial cortex (RSC) has been widely related to spatial and contextual memory. However, we recently demonstrated that the anterior part of RSC (aRSC) is required for object recognition (OR) memory consolidation. In this study, aimed analyze requirement dopaminergic inputs into aRSC OR consolidation in male rats. We observed amnesia at 24-h long-term when infused SCH23390, a D1/D5 dopamine receptors antagonist, immediately after training session. same infusion had no effect on...

In the retrosplenial cortex (RSC), role of cholinergic modulation via α7 nicotinic receptors and their involvement in memory is unknown. recent years, RSC has been shown to deteriorate early stages Alzheimer’s disease (AD). Likewise, system postulated as one those responsible for cognitive impairment patients with AD. Great interest arisen study more specific targets treatment this disease. For reason, we aim processing. We infused a selective receptor antagonist into anterior part (aRSC)...

Background and objectives A controversy regarding the duration of generalized anxiety disorders (GAD) depressive symptoms during COVID-19 pandemic arose, stating that these last a short time, perhaps few months, or they are more persistent over time. After than three years pandemic, this is still question requires an answer. The main goal work was to record levels self-perceived GAD depression in Argentine population at several time points characterize whether were transient persisted...

Since the irruption of coronavirus disease 2019 (COVID-19) planet has submerged in a time concern and uncertainty, with direct impact on people's mental health. Moreover, recurrent outbreaks that periodically harry different regions world constantly refocus concerns to pandemic. Yet, each new wave heats diverse countries situations, including advances their vaccination campaigns. In this research, we studied levels general anxiety disorder (GAD) depression Argentine population across first...

Abstract Background Due to the coronavirus disease 2019 (COVID-19), planet is going through a historical time of exceptional concern and uncertainty, which impacts people’s mental health. Here, we explored levels depression Generalized Anxiety Disorder (GAD) their relation with degree physical activity social interaction during pandemic. Methods We performed structured survey containing PHQ-9 GAD-7 tests evaluate depressive symptoms GAD levels. also asked about weekly level interaction....