A5009565241- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Memory Processes and Influences
- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Nicotinic Acetylcholine Receptors Study
- Neural dynamics and brain function
- Tryptophan and brain disorders
- Psychedelics and Drug Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Child and Adolescent Psychosocial and Emotional Development
- Sirtuins and Resveratrol in Medicine
- Sleep and Wakefulness Research
- Ion channel regulation and function
- Axon Guidance and Neuronal Signaling
- Genomics and Rare Diseases
- Nitric Oxide and Endothelin Effects
- Attention Deficit Hyperactivity Disorder
- Biochemical Analysis and Sensing Techniques
- Photoreceptor and optogenetics research
- Genetic Associations and Epidemiology
- Neurogenesis and neuroplasticity mechanisms
- Cholinesterase and Neurodegenerative Diseases
Favaloro University
2018-2024
Consejo Nacional de Investigaciones Científicas y Técnicas
2014-2024
Instituto de Neurología Cognitiva
2018-2024
University of Buenos Aires
2012-2019
Columbia University
2003-2008
New York State Psychiatric Institute
2006-2008
New York Psychoanalytic Society and Institute
2006-2008
Institute of Astronomy and Space Physics
2002-2005
Experimental Medicine and Biology Institute
2002-2005
Nathan Kline Institute for Psychiatric Research
2003
Various chronic antidepressant treatments increase adult hippocampal neurogenesis, but the functional importance of this phenomenon remains unclear. Here, using genetic and radiological methods, we show that disrupting antidepressant-induced neurogenesis blocks behavioral responses to antidepressants. Serotonin 1A receptor null mice were insensitive neurogenic effects fluoxetine, a serotonin selective reuptake inhibitor. X-irradiation restricted region mouse brain containing hippocampus...
Serotonin [5-hydroxytryptamine (5-HT)] neurotransmission in the central nervous system modulates depression and anxiety-related behaviors humans rodents, but responsible downstream receptors remain poorly understood. We demonstrate that global disruption of 5-HT2A receptor (5HT2AR) signaling mice reduces inhibition conflict anxiety paradigms without affecting fear-conditioned depression-related behaviors. Selective restoration 5HT2AR to cortex normalized These findings indicate a specific...
Most neuropharmacological agents and many drugs of abuse modulate the activity heptahelical G-protein-coupled receptors. Although effects these ligands result from changes in cellular signaling, their neurobehavioral may not correlate with results vitro signal transduction assays. 5-Hydroxytryptamine 2A receptor (5-HT2AR) partial agonists that have similar pharmacological profiles differ behavioral responses they elicit. In studies suggest different acting at same establish distinct patterns...
Significance Neuronal mitochondria are crucial organelles that regulate bioenergetics and also modulate survival function under environmental challenges. Here, we show the neurotransmitter serotonin (5-HT) plays an important role in making of new (mitochondrial biogenesis) cortical neurons, through 5-HT 2A receptor via master regulators mitochondrial biogenesis, SIRT1 PGC-1α. Mitochondrial is enhanced by 5-HT, increasing cellular respiration ATP, energy currency cell. We found reduces...
Often, retrieval cues are not uniquely related to one specific memory, which could lead memory interference. Controlling interference is particularly important during episodic or when remembering events in a spatiotemporal context. Despite clear involvement of prefrontal cortex (PFC) human studies, information regarding the mechanisms and neurotransmitter systems PFC involved scarce. Although serotoninergic system has been linked functionality modulation, its role processing poorly...
Forgetting is a ubiquitous phenomenon that actively promoted in many species. The act of remembering some experiences can cause the forgetting others both humans and rats. We previously found when rats need to retrieve memory guide exploration, it reduces later retention other competing memories encoded environment. As with humans, retrieval-induced (RIF) relies on prefrontal control processes, competition-dependent, cue-independent. RIF thought be driven by inhibitory signals from cortex...
Forgetting is a ubiquitous phenomenon that actively promoted in many species. How and whether organisms' behavioral goals drive which memories are forgotten unknown. Here we show processes essential to controlling goal-directed behavior trigger active forgetting of distracting interfere with goals. When rats need retrieve particular guide exploration, it reduces later retention other encoded environment. As humans, this retrieval-induced competition-dependent, cue-independent reliant on...
Significance Recovering relevant information, while ignoring the irrelevant, is crucial for episodic memory (remembering a particular event at specific temporal and spatial context). Information presented any time could drive retrieval of more than one trace; thus, there should be mechanism to select most trace. However, how brain controls interference not well understood. Here, we analyzed communication between ventral hippocampus (vHPC) medial prefrontal cortex (mPFC) during resolution an...
Medial prefrontal cortex (mPFC) is essential for initial memory processing and expression but its involvement in persistent storage has seldom been studied. Using the hippocampus dependent inhibitory avoidance learning task hippocampus-independent conditioned taste aversion paradigm together with specific dopamine receptor agonists antagonists we found that persistence not formation of long-tem aversive memories requires D1/D5 receptors activation mPFC immediately after training and,...
Memory systems ought to store and discriminate representations of similar experiences in order efficiently guide future decisions. This problem is solved by pattern separation, implemented the dentate gyrus (DG) granule cells support episodic memory formation. Pattern separation enabled tonic inhibitory bombardment generated multiple GABAergic cell populations that strictly maintain low activity levels cells. Somatostatin-expressing are one those interneuron populations, selectively...
Serotonin receptors are targets of drug therapies for a variety neuropsychiatric and neurodegenerative disorders. Cocaine inhibits the re-uptake serotonin (5-HT), dopamine, noradrenaline, whereas caffeine blocks adenosine opens ryanodine in endoplasmic reticulum. We studied how 5-HT affected spontaneous GABAergic transmission from thalamic reticular nucleus. combined whole-cell patch clamp recordings miniature inhibitory post-synaptic currents (mIPSCs) ventrobasal neurons during local (puff)...
Episodic memory, can be defined as the memory for unique events. The serotonergic system one of main neuromodulatory systems in brain appears to play a role it. serotonin 2a receptor (5-HT2aR) principal post-synaptic receptors 5-HT brain, is involved neuropsychiatric and neurological disorders associated with deficits. Recognition ability recognize if particular event or item was previously encountered thus considered, under certain conditions, form episodic memory. As human data suggest...
Serotonin (5-hydroxytryptamine, 5-HT) receptors (5-HTRs) play critical roles in brain and cardiovascular functions. In the vasculature, 5-HT induces potent vasoconstrictions, which aorta are mainly mediated by activation of 5-HT(2A)R subtype. We previously proposed that one signalling mechanism 5-HT-induced vasoconstriction could be c-Src, a member Src tyrosine kinase family. now provide evidence for central role c-Src 5-HT(2A)R-mediated contraction. Inhibition activity with 10 mum...
Context-dependent memories may guide adaptive behavior relaying in previous experience while updating stored information through reconsolidation. Retrieval can be triggered by partial and shared cues. When the cue is presented, most relevant memory should updated. In a contextual version of object recognition task, we examined effect medial PFC (mPFC) serotonin 2a receptor (5-HT2aR) blockade during retrieval reconsolidation competing objects memories. We found that mPFC 5-HT2aR controls...
Successful memory involves not only remembering over time but also keeping memories distinct. The ability to separate similar experiences into distinct is a main feature of episodic memory. Discrimination overlapping representations has been investigated in the dentate gyrus hippocampus (DG), little known about this process other regions such as perirhinal cortex (Prh). We found male rats that brain-derived neurotrophic factor (BDNF) required for separable storage overlapping, distinct,...
The ability to separate similar experiences into differentiated representations is proposed be based on a computational process called pattern separation, and it one of the key characteristics episodic memory. Although separation has been mainly studied in dentate gyrus hippocampus, this cognitive function if thought take place also other regions brain. perirhinal cortex important for acquisition storage object memories, particular memory differentiation. present study was devoted...