A5102849527- Protein Interaction Studies and Fluorescence Analysis
- Hemoglobin structure and function
- Blood Coagulation and Thrombosis Mechanisms
- Mechanical Behavior of Composites
- Hemophilia Treatment and Research
- Neonatal Health and Biochemistry
- Protein Structure and Dynamics
- Gas Sensing Nanomaterials and Sensors
- Neuroscience and Neuropharmacology Research
- Phase-change materials and chalcogenides
- Advanced biosensing and bioanalysis techniques
- Structural Analysis of Composite Materials
- Platelet Disorders and Treatments
- Ion channel regulation and function
- Glass properties and applications
- Blood properties and coagulation
- Electric and Hybrid Vehicle Technologies
- Methemoglobinemia and Tumor Lysis Syndrome
- Temporomandibular Joint Disorders
- Advanced Battery Technologies Research
- Advanced Battery Materials and Technologies
- Textile materials and evaluations
- Dental Implant Techniques and Outcomes
- Electrochemical sensors and biosensors
- Luminescence Properties of Advanced Materials
University of Alberta
2023-2024
University of Delhi
1987-2024
Galgotias University
2024
Aligarh Muslim University
1993-2023
Uttaranchal University
2023
Creative Commons
2023
Optica
2023
Swami Vivekanand Subharti University
2021
National Medical Research Center of Dentistry and Maxillofacial Surgery
2021
University of California, Los Angeles
2009-2020
This research focuses on comparing the two progressive damage models available in explicit nonlinear finite element software LS-Dyna. To explore prediction capabilities terms of mechanical response and dominating failure modes S2 glass woven composites, low velocity impact at four different energies ranging from 27.9 J to 109.7 were considered this study. A macro-homogeneous solid formulated model was simulated understand mechanics laminate under low-velocity impact. The material modeling...
Human serum albumin (HSA), under conditions of low pH, is known to exist in two isomeric forms, the F form at around pH 4.0 and E below 3.0. We studied its conformation acid‐denatured using far‐UV near‐UV CD, binding a hydrophobic probe, 1‐anilinonaphthalene‐8‐sulfonic acid (ANS), thermal transition by tryptophan fluorescence, quenching fluorescence neutral quencher, acrylamide viscosity measurements. The results show that HSA 2.0 characterized significant amount secondary structure, as...
The unfolding of human serum albumin (HSA), a multidomain protein, by urea was followed far-UV circular dichroism (CD), intrinsic fluorescence, and ANS fluorescence measurements. urea-induced transition, which otherwise two-step process with stable intermediate at around 4.8 M concentration as monitored CD underwent single-step cooperative transition in the presence 1.0 KCl. free energy stabilization 1 KCl found to be 1,090 1,200 cal/mol determined respectively.The salt occurred first (0–5.0...
Serotonin (5-hydroxytryptamine, 5-HT) receptors (5-HTRs) play critical roles in brain and cardiovascular functions. In the vasculature, 5-HT induces potent vasoconstrictions, which aorta are mainly mediated by activation of 5-HT(2A)R subtype. We previously proposed that one signalling mechanism 5-HT-induced vasoconstriction could be c-Src, a member Src tyrosine kinase family. now provide evidence for central role c-Src 5-HT(2A)R-mediated contraction. Inhibition activity with 10 mum...
Tissue factor pathway inhibitor-2 (TFPI-2) inhibits XIa, plasma kallikrein, and VIIa/tissue factor; accordingly, it has been proposed for use as an anticoagulant. Full-length TFPI-2 or its isolated first Kunitz domain (KD1) also plasmin; therefore, antifibrinolytic agent. However, the anticoagulant properties of KD1 would diminish function. In this study, structure-based investigations analysis serine protease profiles revealed that coagulation enzymes prefer a hydrophobic residue at P2'...
This paper studies the behavior of S2-glass woven fabric reinforced polymer composite under low-velocity impact at 18–110 J energy. A macro-homogeneous finite element model for prediction their response is implemented, considering non-linear material and intralaminar interlaminar failure modes damage. The accurately predicted permanent indentation caused by impact. By applying Ramberg-Osgood formulation, different initial stiffness values are examined to assess post-impact unloading...
Abstract Purpose To determine whether a fixed partial denture (FPD) or an implant replacement of single missing tooth leads to better masticatory efficiency and patient satisfaction. Materials Methods One‐hundred twenty participants with mandibular right first molars were selected on the basis predefined inclusion exclusion criteria. After obtaining informed consent, 60 randomized teeth‐supported group placement (IMP). The study was divided into following parts: (i) Completion Likert scale...
Tissue factor pathway inhibitor-2 (TFPI-2) is a homologue of TFPI-1 and contains three Kunitz-type domains basic C terminus region. The N-terminal domain TFPI-2 the only inhibitory domain, it inhibits plasma kallikrein, XIa, plasmin. However, levels are negligible (≤20 pM) in context influencing clotting or fibrinolysis. Here, we report that platelets contain significant amounts derived from megakaryocytes. We employed RT-PCR, Western blotting, immunohistochemistry, confocal microscopy to...
Urea-induced equilibrium unfolding of human serum albumin (HSA) when studied by mean residue ellipticity at 222 nm (MRE(222)) or intrinsic fluorescence measurements showed a two-step, three-state transition with stable intermediate around 4.6-5.2 M urea. The presence 2,2,2-trifluoroethanol (TFE) resulted in single-step, two-state significant shift towards higher urea concentration, suggesting the stabilizing effect TFE. free energy stabilization (DeltaDeltaG(D)(H(2)O)) 3.0 TFE was determined...
Abstract Large‐conductance, voltage‐ and Ca 2+ ‐activated K + channels (MaxiK) are broadly expressed ion minimally assembled by four pore‐forming α‐subunits (MaxiKα) typically observed as plasma membrane proteins in various cell types. In murine astrocyte primary cultures, we show that MaxiKα is predominantly confined to the microtubule network. Distinct distribution of was visualized three independent labeling approaches: (1) MaxiKα‐specific antibodies, (2) EGFP‐labeled MaxiKα, (3)...