Robert Whelan
A5050499058- Functional Brain Connectivity Studies
- Attention Deficit Hyperactivity Disorder
- Mental Health Research Topics
- Neural and Behavioral Psychology Studies
- Health, Environment, Cognitive Aging
- Child and Adolescent Psychosocial and Emotional Development
- Dementia and Cognitive Impairment Research
- EEG and Brain-Computer Interfaces
- Behavioral and Psychological Studies
- Advanced Neuroimaging Techniques and Applications
- Neural dynamics and brain function
- Genetic Associations and Epidemiology
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neurotransmitter Receptor Influence on Behavior
- Autism Spectrum Disorder Research
- Substance Abuse Treatment and Outcomes
- Cannabis and Cannabinoid Research
- Memory and Neural Mechanisms
- Prenatal Substance Exposure Effects
- Heart Rate Variability and Autonomic Control
- Cognitive Abilities and Testing
- Schizophrenia research and treatment
- Epigenetics and DNA Methylation
- Obsessive-Compulsive Spectrum Disorders
- Stress Responses and Cortisol
Trinity College Dublin
2016-2025
Global Brain Health Institute
2018-2025
King's College London
2017-2025
MRC Centre for Regenerative Medicine
2025
University of Edinburgh
2025
Inserm
2017-2024
University of California, San Francisco
2022-2024
Universidad Complutense de Madrid
2024
University of Strathclyde
2024
Sorbonne Université
2018-2024
Response inhibition is essential for navigating everyday life. Its derailment considered integral to numerous neurological and psychiatric disorders, more generally, a wide range of behavioral health problems. Response-inhibition efficiency furthermore correlates with treatment outcome in some these conditions. The stop-signal task an tool determine how quickly response implemented. Despite its apparent simplicity, there are many features (ranging from design data analysis) that vary across...
Prominent theories suggest that compulsive behaviors, characteristic of obsessive-compulsive disorder and addiction, are driven by shared deficits in goal-directed control, which confers vulnerability for developing rigid habits. However, recent studies have shown deficient control accompanies several disorders, including those without an obvious element. Reasoning this lack clinical specificity might reflect broader issues with psychiatric diagnostic categories, we investigated whether a...
The traditional view that mental disorders are distinct, categorical has been challenged by evidence highly comorbid and exist on a continuum (e.g., Caspi et al., 2014; Tackett 2013). first objective of this study was to use structural equation modeling model the structure psychopathology in an adolescent community-based sample (N = 2,144) including conduct disorder, attention-deficit/hyperactivity disorder (ADHD), oppositional-defiant (ODD), obsessive-compulsive eating disorders, substance...
Animal studies have shown that the adolescent brain is sensitive to disruptions in endocannabinoid signaling, resulting altered neurodevelopment and lasting behavioral effects. However, few investigated ties between cannabis use development humans.
Abstract Recent studies proposed a general psychopathology factor underlying common comorbidities among psychiatric disorders. However, its neurobiological mechanisms and generalizability remain elusive. In this study, we used large longitudinal neuroimaging cohort from adolescence to young adulthood (IMAGEN) define neuropsychopathological (NP) across externalizing internalizing symptoms using multitask connectomes. We demonstrate that NP might represent unified, genetically determined,...
Abstract Brain clocks, which quantify discrepancies between brain age and chronological age, hold promise for understanding health disease. However, the impact of diversity (including geographical, socioeconomic, sociodemographic, sex neurodegeneration) on brain-age gap is unknown. We analyzed datasets from 5,306 participants across 15 countries (7 Latin American Caribbean (LAC) 8 non-LAC countries). Based higher-order interactions, we developed a deep learning architecture functional...
Cannabis use during adolescence is known to increase the risk for schizophrenia in men. Sex differences dynamics of brain maturation may be particular importance with regard vulnerability male cannabis exposure.
Longitudinal and family-based research suggests that conduct disorder, substance misuse, ADHD involve both unique forms of dysfunction as well more specific dysfunctions to each condition. Using direct measures brain function, this study also found evidence in disorder-specific perturbations.
Rates of cannabis use among adolescents are high, and increasing concurrent with changes in the legal status marijuana societal attitudes regarding its use. Recreational is understudied, especially adolescent period when neural maturation may make users particularly vulnerable to effects Δ-9-tetrahydrocannabinol (THC) on brain structure. In current study, we used voxel-based morphometry compare gray matter volume (GMV) forty-six 14-year-old human (males females) just one or two instances...
Genetic factors and socioeconomic status (SES) inequalities play a large role in educational attainment, both have been associated with variations brain structure cognition. However, genetics SES are correlated, no prior study has assessed their neural associations independently. Here we used polygenic score for attainment (EduYears-PGS), as well SES, longitudinal of 551 adolescents to tease apart genetic environmental development Subjects received structural MRI scan at ages 14 19. At time...
Abstract The functional neuroanatomy and connectivity of reward processing in adults are well documented, with relatively less research on adolescents, a notable gap given this developmental period's association altered sensitivity. Here, large sample ( n = 1,510) adolescents performed the monetary incentive delay (MID) task during magnetic resonance imaging. Probabilistic maps identified brain regions that were reliably responsive to anticipation receipt, prediction errors derived from...
Importance Biomarkers that are predictive of outcomes in individuals at risk psychosis would facilitate individualized prognosis and stratification strategies. Objective To investigate whether proteomic biomarkers may aid prediction transition to psychotic disorder the clinical high-risk (CHR) state adolescent experiences (PEs) general population. Design, Setting, Participants This diagnostic study comprised 2 case-control studies nested within European Network National Schizophrenia...
Alzheimer's disease (AD) is the leading cause of dementia, accounting for 70% cases worldwide. By 2050, dementia prevalence will have tripled, with most new occurring in low- and middle-income countries. Mild cognitive impairment (MCI) a stage between healthy aging marked by deficits that do not impair daily living. People MCI are at increased risk an average progression rate 39% within 5 years. There urgent need low-cost, accessible objective methods to facilitate early detection....
The predictive coding theory of allostatic-interoceptive load states that brain networks mediating autonomic regulation and interoceptive-exteroceptive balance regulate the internal milieu to anticipate future needs environmental demands. These functions seem be distinctly compromised in behavioral variant frontotemporal dementia (bvFTD), including alterations network (AIN). Here, we hypothesize bvFTD is typified by an overload.