Bernd Ittermann
A5031881090- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Neural and Behavioral Psychology Studies
- Attention Deficit Hyperactivity Disorder
- Neurotransmitter Receptor Influence on Behavior
- Mental Health Research Topics
- Advanced Neuroimaging Techniques and Applications
- Genetic Associations and Epidemiology
- Child and Adolescent Psychosocial and Emotional Development
- Cognitive Abilities and Testing
- Silicon and Solar Cell Technologies
- Ultrasound and Hyperthermia Applications
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Cardiac Imaging and Diagnostics
- Advanced NMR Techniques and Applications
- Semiconductor materials and interfaces
- Substance Abuse Treatment and Outcomes
- Schizophrenia research and treatment
- Cannabis and Cannabinoid Research
- Epigenetics and DNA Methylation
- Prenatal Substance Exposure Effects
- Ion-surface interactions and analysis
- Atomic and Subatomic Physics Research
- Heart Rate Variability and Autonomic Control
- Health, Environment, Cognitive Aging
Physikalisch-Technische Bundesanstalt
2016-2025
Universidade Federal de São Paulo
2022
Universidade Federal do ABC
2022
Charité - Universitätsmedizin Berlin
2011-2021
Fudan University
2018-2020
Neurim Pharmaceuticals (Israel)
2020
Lundbeck (Denmark)
2020
Cambridge Cognition (United Kingdom)
2020
Shanghai Center for Brain Science and Brain-Inspired Technology
2020
Shanghai Institute for Science of Science
2020
During rest, brain activity is synchronized between different regions widely distributed throughout the brain, forming functional networks. However, molecular mechanisms supporting connectivity remain undefined. We show that networks defined with resting-state magnetic resonance imaging can be recapitulated by using measures of correlated gene expression in a post mortem tissue data set. The set 136 genes we identify significantly enriched for ion channels. Polymorphisms this affect large...
A major methodological challenge of functional near-infrared spectroscopy (fNIRS) is its high sensitivity to haemodynamic fluctuations in the scalp. Superficial contribute on one hand physiological noise fNIRS, impairing signal-to-noise ratio, and may other be erroneously attributed cerebral changes, leading false positives fNIRS experiments. Here we explore localisation, time course origin task-evoked superficial signals present a method separate them from cortical signals. We used...
Objective: The authors examined whether alterations in the brain’s reward network operate as a mechanism across spectrum of risk for depression. They then tested these are specific to anhedonia compared with low mood and they predictive depressive outcomes. Method: Functional MRI was used collect blood-oxygen-level-dependent (BOLD) responses anticipation monetary incentive task 1,576 adolescents community-based sample. Adolescents current subthreshold depression clinical were matched healthy...
The two hemispheres of the human brain differ functionally and structurally. Despite over a century research, extent to which asymmetry is influenced by sex, handedness, age, genetic factors still controversial. Here we present largest ever analysis subcortical asymmetries, in harmonized multi-site study using meta-analysis methods. Volumetric seven structures was assessed 15,847 MRI scans from 52 datasets worldwide. There were sex differences globus pallidus putamen. Heritability estimates,...
Animal studies have shown that the adolescent brain is sensitive to disruptions in endocannabinoid signaling, resulting altered neurodevelopment and lasting behavioral effects. However, few investigated ties between cannabis use development humans.
Abstract Recent studies proposed a general psychopathology factor underlying common comorbidities among psychiatric disorders. However, its neurobiological mechanisms and generalizability remain elusive. In this study, we used large longitudinal neuroimaging cohort from adolescence to young adulthood (IMAGEN) define neuropsychopathological (NP) across externalizing internalizing symptoms using multitask connectomes. We demonstrate that NP might represent unified, genetically determined,...
Video game playing is a frequent recreational activity. Previous studies have reported an involvement of dopamine-related ventral striatum. However, structural brain correlates video not been investigated. On magnetic resonance imaging scans 154 14-year-olds, we computed voxel-based morphometry to explore differences between and infrequent players. Moreover, assessed the Monetary Incentive Delay (MID) task during functional Cambridge Gambling Task (CGT). We found higher left striatal grey...
Increased risk-taking behavior has been associated with addiction, a disorder also linked to abnormalities in reward processing. Specifically, an attenuated response of reward-related areas (e.g., the ventral striatum) nondrug cues reported addiction. One unanswered question is whether preference striatal processing absence substance abuse.Functional and structural MRI was performed 266 healthy young adolescents 31 reporting potentially problematic use. Activation during anticipation (using...
T1 mapping and extracellular volume (ECV) have the potential to guide patient care serve as surrogate end-points in clinical trials, but measurements differ between cardiovascular magnetic resonance (CMR) scanners pulse sequences. To help deliver global care, we developed a phantom-based quality assurance (QA) system for verification of measurement stability over time at individual sites, with further aims generalization results across vendor systems, software versions imaging We thus...
Transcranial direct current stimulation (tDCS) modulates human behavior, neuronal patterns, and metabolite concentrations, with exciting potential for neurorehabilitation. However, the understanding of tDCS-induced alterations on level is incomplete, conclusions from young adults, in whom majority studies have been conducted, cannot be easily transferred to older populations. Here, we investigated effects adults ( N = 48; age range, 50–79 years) using magnetic resonance spectroscopy quantify...
Novelty-seeking tendencies in adolescents may promote innovation as well problematic impulsive behaviour, including drug abuse. Previous research has not clarified whether neural hyper- or hypo-responsiveness to anticipated rewards promotes vulnerability these individuals. Here we use a longitudinal design track 144 novelty-seeking at age 14 and 16 determine activity response predicts use. We find that diminished BOLD mesolimbic (ventral striatal midbrain) prefrontal cortical (dorsolateral...
Playing video games is a common recreational activity of adolescents. Recent research associated frequent game playing with improvements in cognitive functions. Improvements cognition have been related to grey matter changes prefrontal cortex. However, fine-grained analysis human brain structure relation gaming lacking. In magnetic resonance imaging scans 152 14-year old adolescents, FreeSurfer was used estimate cortical thickness. Cortical thickness across the whole surface correlated...
Rates of cannabis use among adolescents are high, and increasing concurrent with changes in the legal status marijuana societal attitudes regarding its use. Recreational is understudied, especially adolescent period when neural maturation may make users particularly vulnerable to effects Δ-9-tetrahydrocannabinol (THC) on brain structure. In current study, we used voxel-based morphometry compare gray matter volume (GMV) forty-six 14-year-old human (males females) just one or two instances...
Abstract The functional neuroanatomy and connectivity of reward processing in adults are well documented, with relatively less research on adolescents, a notable gap given this developmental period's association altered sensitivity. Here, large sample ( n = 1,510) adolescents performed the monetary incentive delay (MID) task during magnetic resonance imaging. Probabilistic maps identified brain regions that were reliably responsive to anticipation receipt, prediction errors derived from...
Genetic factors and socioeconomic status (SES) inequalities play a large role in educational attainment, both have been associated with variations brain structure cognition. However, genetics SES are correlated, no prior study has assessed their neural associations independently. Here we used polygenic score for attainment (EduYears-PGS), as well SES, longitudinal of 551 adolescents to tease apart genetic environmental development Subjects received structural MRI scan at ages 14 19. At time...
The firing of mesolimbic dopamine neurons is important for drug-induced reinforcement, although underlying genetic factors remain poorly understood. In a recent genome-wide association metaanalysis alcohol intake, we identified suggestive SNP rs26907 in the ras-specific guanine-nucleotide releasing factor 2 ( RASGRF2 ) gene, encoding protein that mediates Ca 2+ -dependent activation ERK pathway. We performed functional characterization this gene relation to alcohol-related phenotypes and...
Objective To investigate the damage to retinal nerve fiber layer as part of anterior visual pathway well an impairment neuronal and axonal integrity in cortex posterior with complementary neuroimaging techniques, correlate our results patients' clinical symptoms concerning pathway. Design, Subjects Methods Survey 86 patients relapsing-remitting multiple sclerosis that were subjected thickness (RNFLT) measurement by optical coherence tomography, a routine MRI scan including calculation brain...