A5022062828- Neurotransmitter Receptor Influence on Behavior
- Memory and Neural Mechanisms
- Attention Deficit Hyperactivity Disorder
- Neural and Behavioral Psychology Studies
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Receptor Mechanisms and Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Obsessive-Compulsive Spectrum Disorders
- Neural dynamics and brain function
- Intracerebral and Subarachnoid Hemorrhage Research
- Olfactory and Sensory Function Studies
- Functional Brain Connectivity Studies
- Regulation of Appetite and Obesity
- Neuroscience of respiration and sleep
- Tryptophan and brain disorders
- Sleep and Wakefulness Research
- Neurogenesis and neuroplasticity mechanisms
- Infant Health and Development
- Circadian rhythm and melatonin
- Behavioral and Psychological Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Pain Mechanisms and Treatments
New York University
2015-2024
NYU Langone Health
2018-2024
Neurosciences Institute
2015-2023
Columbia University Irving Medical Center
2015-2021
University of Cambridge
2011-2020
Inserm
2013-2020
Université Paris Cité
2019-2020
Sorbonne Paris Cité
2020
Université Paris-Sud
2019
Neuroscience Institute
2014-2019
Both impulsivity and novelty-seeking have been suggested to be behavioral markers of the propensity take addictive drugs. However, their relevance for vulnerability compulsively seek drugs, which is a hallmark feature addiction, unknown. We report here that, whereas high reactivity novelty predicts initiate cocaine self-administration, development addiction-like behavior in rats, including persistent or compulsive drug-taking face aversive outcomes. This study shows experimental evidence...
Maternal care, including by non-biological parents, is important for offspring survival1-8. Oxytocin1,2,9-15, which released the hypothalamic paraventricular nucleus (PVN), a critical maternal hormone. In mice, oxytocin enables neuroplasticity in auditory cortex recognition of pup distress15. However, it unclear how initial parental experience promotes signalling and cortical plasticity reliable care. Here we continuously monitored behaviour female virgin mice co-housed with an experienced...
Physical exercise improves motor performance in individuals with Parkinson9s disease and elevates mood those depression. Although underlying factors have not been identified, clues arise from previous studies showing a link between cognitive benefits of increases brain-derived neurotrophic factor (BDNF). Here, we investigated the influence voluntary wheel-running on BDNF levels striatum young male wild-type (WT) mice, striatal release key motor-system transmitter, dopamine (DA). Mice were...
The orbitofrontal cortex (OFC) is implicated in a variety of adaptive decision-making processes. Human studies suggest that there functional dissociation between medial and lateral OFC (mOFC lOFC, respectively) subregions when performing certain choice procedures. However, little work has examined the consequences manipulations on decision making rodents. In present experiments, impulsive was assessed by evaluating intolerance to delayed, but economically optimal, reward options using...
The stop-signal paradigm measures the ability to stop a motor response after its execution has been initiated. Impairments in inhibiting inappropriate behavior and prolonged reaction times (SSRTs) are characteristic of several psychiatric disorders, most notably attention deficit/hyperactivity disorder. While there is relative consensus regarding anatomical substrates behavioral inhibition, neurochemical imbalance responsible for deficits stopping displayed by impulsive individuals still...
Defining the neural and neurochemical substrates of response inhibition is crucial importance for study treatment pathologies characterized by impulsivity such as attention-deficit/hyperactivity disorder addiction. The stop-signal task (SST) one most popular paradigms used to speed efficacy inhibitory processes in humans other animals. Here we investigated effect temporarily inactivating different prefrontal subregions rat means muscimol microinfusions on SST performance. We found that...
Dopamine and dopamine-receptor function are often implicated in behavioral inhibition, deficiencies within inhibition processes linked to attention deficit/hyperactivity disorder (ADHD), schizophrenia, obsessive-compulsive disorder, drug addiction. In the stop-signal task, which measures speed of process [stop-signal reaction time (SSRT)], psychostimulant-related improvement SSRT ADHD is with dopamine function. However, precise nature dopaminergic control over remains unclear. This study...
Novelty-seeking tendencies in adolescents may promote innovation as well problematic impulsive behaviour, including drug abuse. Previous research has not clarified whether neural hyper- or hypo-responsiveness to anticipated rewards promotes vulnerability these individuals. Here we use a longitudinal design track 144 novelty-seeking at age 14 and 16 determine activity response predicts use. We find that diminished BOLD mesolimbic (ventral striatal midbrain) prefrontal cortical (dorsolateral...
Researchers are becoming increasingly interested in the role of hippocampus pattern separation, a process which keeps items distinct memory. In this study, we develop and test new automated touchscreen-based method for studying separation rodents. Rats were trained to discriminate locations on computer screen that varied their similarity, is, distance apart screen. Animals with lesions dorsal impaired when discriminated close together but not they far apart, indicating separation. This...
Previous work has demonstrated a profound effect of N-methyl-D: -aspartic acid receptor (NMDAR) antagonism in the infralimbic cortex (IL) to selectively elevate impulsive responding rodent reaction time paradigm. However, mechanism underlying this is unclear.
Significance We characterize in humans a coordinated network of brain activity describing neurobehavioral correlates reward anticipation. The involves nodes striatal and cortical regions, which are preferentially associated with distinct externalizing behaviors—hyperactivity alcohol consumption—suggesting that the heterogeneity reward-related behaviors might be accounted for by different association patterns their connecting links. In genome-wide study node subsequent functional validation...
Abstract Introduction Cerebrovascular pathology is an early and causal hallmark of Alzheimer's disease (AD), in need effective therapies. Methods Based on the success our previous vitro studies, we tested for first time a model AD cerebral amyloid angiopathy (CAA), carbonic anhydrase inhibitors (CAIs) methazolamide acetazolamide, Food Drug Administration–approved against glaucoma high‐altitude sickness. Results Both CAIs reduced cerebral, vascular, glial beta (Aβ) accumulation caspase...