Dirk Lanzerath
A5027263612- Ethics in medical practice
- Mental Health and Psychiatry
- Medical and Health Sciences Research
- Neuroethics, Human Enhancement, Biomedical Innovations
- Ethics in Clinical Research
- Ethics and Legal Issues in Pediatric Healthcare
- Medical History and Research
- Ecology, Conservation, and Geographical Studies
- Biomedical Ethics and Regulation
- Palliative Care and End-of-Life Issues
- Attention Deficit Hyperactivity Disorder
- Space Science and Extraterrestrial Life
- Economic and Social Issues
- CRISPR and Genetic Engineering
- Neurotransmitter Receptor Influence on Behavior
- Functional Brain Connectivity Studies
- Ethics in Business and Education
- Innovation, Technology, and Society
- Environmental Science and Technology
- Academic integrity and plagiarism
- Innovative Approaches in Technology and Social Development
- Nutrition, Genetics, and Disease
- Substance Abuse Treatment and Outcomes
- Bioeconomy and Sustainability Development
- Artificial Intelligence in Healthcare and Education
University of Bonn
2015-2023
Amsterdam University Medical Centers
2023
Vrije Universiteit Amsterdam
2023
Deutsches Herzzentrum der Charité
2017-2021
Association of European Renewable Energy Research Centres
2017-2021
Pensoft Publishers (Bulgaria)
2020
National Museum of Natural History
2020
Kiel University
2020
Coburg University of Applied Sciences
2020
European Research Council
2017
During rest, brain activity is synchronized between different regions widely distributed throughout the brain, forming functional networks. However, molecular mechanisms supporting connectivity remain undefined. We show that networks defined with resting-state magnetic resonance imaging can be recapitulated by using measures of correlated gene expression in a post mortem tissue data set. The set 136 genes we identify significantly enriched for ion channels. Polymorphisms this affect large...
Novelty-seeking tendencies in adolescents may promote innovation as well problematic impulsive behaviour, including drug abuse. Previous research has not clarified whether neural hyper- or hypo-responsiveness to anticipated rewards promotes vulnerability these individuals. Here we use a longitudinal design track 144 novelty-seeking at age 14 and 16 determine activity response predicts use. We find that diminished BOLD mesolimbic (ventral striatal midbrain) prefrontal cortical (dorsolateral...
As COVID-19 continues to spread, a variety of tracking apps (CTAs) have been introduced help contain the pandemic. Deployment this technology poses serious challenges effectiveness, technological problems and risks privacy equity. The ethical use CTAs depends heavily on protection voluntariness. Voluntary implies not only absence legal obligation employ app but also more subtle forms coercion such as enforced exclusion from certain social work activities. individual rights voluntary can be...
Significance We characterize in humans a coordinated network of brain activity describing neurobehavioral correlates reward anticipation. The involves nodes striatal and cortical regions, which are preferentially associated with distinct externalizing behaviors—hyperactivity alcohol consumption—suggesting that the heterogeneity reward-related behaviors might be accounted for by different association patterns their connecting links. In genome-wide study node subsequent functional validation...
Alcohol abuse is highly prevalent, but little understood about the molecular causes. Here, we report that Ras suppressor 1 (Rsu1) affects ethanol consumption in flies and humans. Drosophila lacking Rsu1 show reduced sensitivity to ethanol-induced sedation. We required adult nervous system for normal it acts downstream of integrin cell adhesion molecule upstream Ras-related C3 botulinum toxin substrate (Rac1) GTPase regulate actin cytoskeleton. In an preference assay, global loss causes high...
Universities and other research institutions are increasingly providing additional training in integrity to improve the quality reliability of research. Various courses have been developed, with diverse learning goals content. Despite importance that focuses on moral character professional virtues, there remains a lack adopts virtue ethics approach. To address this, we, European Commission-funded consortium, designed train-the-trainer programme for integrity. The is based (1) ethics, (2)...
Abstract Für die Forschung mit Gesundheitsdaten aus der Versorgung stellt informierte Einwilligung eine große Herausforderung dar. ‚Broad consent‘ und trust-basierte Governance-Strukturen werden diskutiert, um Datenschutz Gemeinwohl auszubalancieren. Gleichzeitig muss aber auch – wenn an den Gemeinsinn Patient:innen zum Datenteilen appelliert wird auf gerechte Verteilung Ergebnisse geachtet werden. Ein Access and Benefit-Sharing-Ansatz könnte Solidarität Gerechtigkeit stärken, Transparenz...
Abstract Traditional models of future alcohol use in adolescents have used variable-centered approaches, predicting from a set variables across entire samples or populations. Following the proposition that predictive factors may vary as function family history, we two-pronged approach by first defining clusters familial risk, followed prediction analyses within each cluster. Thus, for time adolescents, tested whether with history drug abuse exhibit predictors different without history. We...
The Path2Integrity project is a two-component coordination and support action to enhance research integrity cultures. develops fosters role-models rotatory role-play scenarios for secondary school students, undergraduates, graduates, early career researchers. A campaign scientific facts about role-models, raises awareness of within schools universities. complementary handbook instructions, which contains vivid stories involving role-playing increases students’ ability form judgements the...
To reduce the global burden of COVID-19 pandemic, there is an urgent need to develop a safe vaccine. Vaccine development usually takes many years as it goes through several different phases. hasten vaccine development, has been suggested that final stage could be replaced with human challenge trial (HCT). Volunteers would intentionally infected SARS-CoV-2 see how candidate works. infect healthy being potentially deadly virus contrary highest ethical standards in medical research. This...
Importance The development of an alcohol use disorder in adolescence is associated with increased risk future dependence. differential associations factors over the course 8 years are important for preventive measures. Objective To determine risk-taking aspects personality, social factors, brain functioning, and familial hazardous adolescents years. Design, Setting, Participants IMAGEN multicenter longitudinal cohort study included recruited from European schools Germany, UK, France, Ireland...
Objectives To investigate whether life-sustaining measures in medical emergency situations are less accepted for an anticipated own future of living with dementia, and to test a resource-oriented, contrast deficit-oriented video about the same demented person, would increase acceptance such life-saving measures. Design Experimental study conducted between September 2012 February 2013. Setting Community dwelling female volunteers region Bonn, Germany. Participants 278 women aged 19 89 (mean...
Recent breakthroughs in psychiatric genetics have identified genetic risk factors of yet unknown clinical value. A main ethical principal the context research as well future testing is respect for a person's autonomy to decide whether undergo testing, and whom grant access data. However, experience within setting has indicated controversies surrounding attitudes toward this principal. This study aimed explore concerning right individuals self‐determine disclosure results, determine these are...