A5002628039- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- Fermentation and Sensory Analysis
- Microbial Metabolism and Applications
- Electrochemical sensors and biosensors
- Biochemical and biochemical processes
- Electrochemical Analysis and Applications
- Nanocluster Synthesis and Applications
- Advanced Biosensing Techniques and Applications
- RNA Interference and Gene Delivery
- RNA and protein synthesis mechanisms
- Tea Polyphenols and Effects
- Advanced Nanomaterials in Catalysis
- Nanopore and Nanochannel Transport Studies
- Mitochondrial Function and Pathology
- Conducting polymers and applications
- SARS-CoV-2 detection and testing
- MicroRNA in disease regulation
- Carbon and Quantum Dots Applications
- Fungal Biology and Applications
- Food Quality and Safety Studies
- CRISPR and Genetic Engineering
- Horticultural and Viticultural Research
- Metabolism and Genetic Disorders
- Genomics and Rare Diseases
Sichuan Normal University
2022-2024
Fujian Medical University
2024
Fuzhou Maternity and Child Health Care Hospital
2024
University of Science and Technology of China
2018-2023
Jiangsu University
2023
Hefei University
2019-2020
Chinese Academy of Sciences
2009-2019
Northeast Agricultural University
2016-2019
National Center for Women and Children’s Health, China CDC
2019
Changchun Institute of Applied Chemistry
2015-2019
Electrochemiluminescence (ECL)-functionalized metal–organic frameworks (MOFs) have attracted increasing attention in biosensing virtue of their diverse and tunable optical properties. A famous ECL luminophore, carboxyl-rich tris(4,4′-dicarboxylic acid-2,2′-bipyridyl) ruthenium(II) (Ru(dcbpy)32+), possesses the characteristics good water solubility excellent performance also has potential to be organic ligand frameworks. Herein, functionalized MOF nanosheets (RuMOFNSs) containing plenty...
Ratiometric electrochemiluminescence (ECL) has attracted special focus in the biological analysis field, because it could eliminate environmental interference and allow for precise measurement. Herein, a dual-wavelength ratiometric ECL biosensor was designed detection of cardiac troponin I (cTnI), where (4,4′-dicarboxylic acid-2,2′-bipyridyl) ruthenium(II) (Ru(dcbpy)32+) Au nanoparticle-loaded graphene oxide/polyethylenimine (GPRu–Au) nanomaterial acts as an acceptor, nanoparticle-modified...
In this study, we proposed a ratiometric electrochemiluminescent (ECL)/electrochemical (EC) biosensor based on duplex-specific nuclease (DSN)-assisted target recycling and multilayer catalytic hairpin assembly (CHA) amplification cascades for the detection of microRNA (miRNA). The DSN-assisted transformed miRNAs into large number ssDNA, which then catalyzed CHA cascade to produce numerous long dsDNA duplexes Hn/Hn+1 (n = 2, 4, 6, ...). Then displaced ferrocene (Fc)-labeled ssDNA (Sx+1, x 1,...
The early and rapid diagnosis of acute myocardial infarction (AMI) is great significance to its treatment. Here, we developed an electrochemiluminescence biosensor based on entropy-driven strand displacement reaction (ETSD) a tetrahedral DNA nanostructure (TDN) for the detection potential AMI biomarker microRNA-133a. In presence target, numerous Ru(bpy)32+-labeled signal probes (SP) were released from preformed three-strand complexes through process ETSD. ETSD cycle greatly amplified input...
A novel ratiometric electrochemiluminescence (ECL)-electrochemical (EC) hybrid biosensor with a high accuracy and reproducibility was fabricated for the ultrasensitive detection of miRNA-133a. With help DNA tetrahedron nanostructure hybridization chain reaction dual amplification strategy, limit 12.17 aM miRNA-133a obtained.
Measurement of cardiac troponin I in the blood is crucial for early diagnosis acute myocardial infarction. Herein, a novel and ultrasensitive electrochemiluminescence (ECL) immunosensor has been developed determination (cTnI) by using Au nanoclusters hybridization chain reaction (HCR) signal amplification. In this ECL immunosensor, were dual-labeled at each end hairpin DNA (H1 H2) acted as luminophore. initiator strands (T1) secondary antibody (Ab2) conjugated on nanoparticles (AuNPs) to...
Inspired by the coreactive activity of carbon nanodots (CDs) and branched polyethylenimine (BPEI) toward electrochemiluminescence (ECL) Ru(bpy)32+, a highly luminescent self-enhanced ECL nanohybrid (Ru-BCDs) was synthesized through covalently linking BPEI-coated dots (BCDs) with Tris (4,4′-dicarboxylic acid-2,2′-bipyridyl) ruthenium(II) dichloride (Ru(dcbpy)32+). The composition morphological characterization demonstrated that spherical Ru-BCDs particles 12.1 ± 1.4 nm diameter were obtained....
<h3>Objective:</h3> To identify a new genetic cause of distal hereditary motor neuropathy (dHMN), which is also known as variant Charcot-Marie-Tooth disease (CMT), in Chinese family. <h3>Methods:</h3> We investigated family with dHMN clinically, electrophysiologically, and genetically. screened for the mutations 28 CMT or related pathogenic genes using an originally designed microarray resequencing DNA chip. <h3>Results:</h3> Investigation history revealed autosomal dominant transmission...
A versatile and sensitive quantum dot (QD)-based "signal-off" electrochemiluminescence (ECL) sensing system was constructed using target-initiated dual Mg2+-dependent DNAzyme (MNAzyme) recycling catalytic hairpin assembly (CHA) amplification strategies. After the cascade amplification, numerous ferrocene-labeled Y-shaped DNA complexes generated on QD-modified electrode surface. In presence of hemin, moreover, terminal sequence formed complex could assemble into hemin/G-quadruplex. Therefore,...
Achieving rapid and highly sensitive detection of biomarkers is crucial for disease diagnosis treatment. Here, a versatile dual-amplification electrochemiluminescence (ECL) biosensing platform was constructed target based on DNA nanostructures catalyzed hairpin assembly (CHA). Specifically, when the present, it would hybridize with auxiliary strands (D1 D2) to form an I-shaped nanostructure, which in turn triggered subsequent catalytic reaction generate plenty double-stranded complexes...
Abstract Formaldehyde is susceptible to illegal addition foodstuffs extend their shelf life due its antimicrobial, preservative and bleaching properties. In this study, a self‐supporting “nanosheet on nanosheet” arrays electrocatalyst with core‐shell heterostructure was prepared in situ by coupling NiCo layer double hydroxide 2D ZIF derived Co‐nitrogen‐doped porous carbon cloth (Co−N/C@NiCo‐LDH NSAs/CC). Co−N/C nanosheet act as scaffold core good electrical conductivity, providing more...
Ethyl acetate, a characteristic flavor compound in light-flavor Baijiu (LFB), plays pivotal role defining its sensory profile. Insufficient concentrations fermented grains may diminish the quality of Baijiu. Indigenous microbial bioaugmentation has proven effective improving by reshaping community and modulating metabolism within fermentation ecosystems. This study investigated effects Jiuqu fortified with an indigenous Saccharomycopsis fibuligera Y162 on community, physicochemical...
In recent years, self-enhanced tris(bipyridine) ruthenium(II)-based luminescence systems have achieved great development in electrochemiluminescence (ECL) but are seldom mentioned chemiluminescence (CL). Herein, a CL luminophore with excellent behavior was synthesized by covalently cross-linking tris(4,4'-dicarboxylic acid-2,2'-bipyridyl) ruthenium(II) dichloride ([Ru(dcbpy)3]Cl2) branched polyethylenimine (BPEI) one molecule (BPEI-Ru(II)), which then self-assembled into nanoparticles...
The detection of multiple biomarkers is great significance to the accurate diagnosis diseases. Herein, in this work, we constructed an electrochemiluminescence (ECL) cascade amplification platform for dual acute myocardial infarction (AMI)-related microRNA detection. Zn2+-dependent DNAzyme digestion reaction initiated by miR-133a and duplex-specific nuclease (DSN) cleavage circuit miR-499 were carried out independently form a fuel hairpin DNA active initiator strand, respectively, trigger...
Abstract Herein, a label‐free and immobilization‐free electrochemiluminescence resonance energy transfer (ECL‐RET) system based on graphitic carbon nitride nanosheets (GCNNs)/Ru(phen) 3 2+ donor/acceptor pair is developed, in which the ECL‐RET regulated by regulating diffusivity of Ru(phen) molecules toward negatively charged GCNNs through logically programmed DNA hybridization reactions. The two optical signals (445 nm) (593 show completely opposite changes same one‐time reaction. Based...