A5047720959- Fermentation and Sensory Analysis
- Liver Disease Diagnosis and Treatment
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Gut microbiota and health
- Food Quality and Safety Studies
- Chronic Kidney Disease and Diabetes
- Acute Kidney Injury Research
- Biochemical and biochemical processes
- Diet and metabolism studies
- Lipid metabolism and disorders
- Gastric Cancer Management and Outcomes
- Extracellular vesicles in disease
- Circular RNAs in diseases
- Tea Polyphenols and Effects
- Salivary Gland Tumors Diagnosis and Treatment
- Acne and Rosacea Treatments and Effects
- Hepatitis B Virus Studies
- Lung Cancer Diagnosis and Treatment
- RNA Research and Splicing
- Nutrition and Health in Aging
- Immune Response and Inflammation
- Fungal Biology and Applications
- Gastrointestinal Tumor Research and Treatment
Beijing Anding Hospital
2025
Capital Medical University
2020-2025
Zhongda Hospital Southeast University
2022-2024
Beijing University of Chemical Technology
2024
Anhui Medical University
2010-2024
Second Hospital of Anhui Medical University
2022-2024
Shanghai Ocean University
2024
Jiangsu University
2018-2024
West China Hospital of Sichuan University
2011-2023
Chinese University of Hong Kong
2020-2023
The microbiome in fermentation has direct impacts on the quality of fermented foods and is great scientific commercial interest. Despite considerable effort to explain microbial metabolism associated with food fermentation, role pu-erh tea remains unknown. Here, we applied integrated meta-omics approaches characterize two repeated fermentations tea. Metabarcoding analysis bacterial 16S rRNA genes showed a decrease proportion Proteobacteria an increase abundance Firmicutes during...
Backgrounds and Aims Activation of hepatic stellate cells (HSCs) is a central driver fibrosis. This study aimed to elucidate the role deacetylase sirtuin 6 (Sirt6) in HSC activation liver Approach Results Gain‐of‐function loss‐of‐function models were used function Sirt6 activation. Mass spectrometry was determine specific acetylation site. The lecithin retinol acyltransferase–driven cyclization recombination recombinase construct (CreERT2) mouse line created generate HSC‐specific conditional...
Acne vulgaris is a chronic inflammatory dermatosis affecting approximately 85% of adolescents. There are many factors contributing to the development this ailment. A recent study indicated that gut microbiota takes part in pathogenesis acne. We aimed investigate link between acne and microbiota. total 31 moderate severe patients healthy controls were enrolled. collected their feces, was evaluated by hypervariable regions 16S rRNA genes through high-throughput sequencing. identified links...
Crop and aquatic animal co-culture systems have been used for over 1200 years can very efficiently utilize nutrients materials available in agroecology settings. These are sustainable forms of agriculture, extensively practiced worldwide. Microorganisms play critical roles promoting ecosystem nutrient transformations material circulations. However, the long-term effects this farming system on soil health microbial community stability, addition to their relationships with rice yields, remain...
Obesity is associated with altered gut microbiome composition but data across different populations remain inconsistent. We meta-analyzed publicly available 16S-rRNA sequence datasets from 18 studies and identified differentially abundant taxa functional pathways of the obese microbiome. Most genera (
Sarcopenia is recognized as a major public health concern because of its association with several adverse events. Beta-hydroxy-beta-methylbutyrate (HMB) supplementation reportedly delays the loss muscle mass and function; however, effect HMB on sarcopenia remains inconclusive. We aimed to evaluate impact intervention strength, physical performance, body compositions, inflammatory factors in older adults sarcopenia. Randomized, double-blind, placebo-controlled trial. This study included...
Extracellular signal-regulated kinases 1 and 2 (ERK1/2) are serine/threonine function as regulators of cellular proliferation differentiation. Recently, we demonstrated that inhibition ERK1/2 alleviates the development progression hyperuricemia nephropathy (HN). However, its potential roles in uric acid-induced tubular epithelial-mesenchymal transition (EMT) epithelial cell injury unknown. In this study, showed hyperuricemic induced EMT characterized by downregulation E-cadherin upregulation...
Epigenetic targeting of the maladaptive vascular niche in fibrotic liver blocks fibrosis by alleviating fibrogenic angiocrine IGFBP7 and ADAMTS1.
: Cisplatin nephrotoxicity is an important cause of acute kidney injury (AKI), limiting cisplatin application in cancer therapy. Growing evidence has suggested that genome instability, telomeric dysfunction, and DNA damage were involved the tubular epithelial cells (TECs) cisplatin-induced AKI (cAKI). However, exact mechanism largely unknown.
The transition from acute kidney injury (AKI) to chronic disease (CKD) is a critical clinical issue. Although previous studies have suggested macrophages as key player in promoting inflammation and fibrosis during this transition, the heterogeneity dynamic characterization of are still poorly understood. Here, we used integrated single-cell RNA sequencing spatial transcriptomic characterize spatiotemporal murine AKI-to-CKD model unilateral ischemia-reperfusion injury. A marked increase...
Suicide is a complex behavior strongly associated with depression. Despite extensive research, an objective biomarker for evaluating suicide risk precisely and timely still lacking. Using the precision resting-state fMRI method, we studied 61 depressive patients ideation (SI) or attempt (SA), 35 without SI to explore functional biomarkers of risk. Among them, 21 participants also completed electroconvulsive therapy (ECT) treatment, allowing examination changes across different states within...
Ethyl acetate, a characteristic flavor compound in light-flavor Baijiu (LFB), plays pivotal role defining its sensory profile. Insufficient concentrations fermented grains may diminish the quality of Baijiu. Indigenous microbial bioaugmentation has proven effective improving by reshaping community and modulating metabolism within fermentation ecosystems. This study investigated effects Jiuqu fortified with an indigenous Saccharomycopsis fibuligera Y162 on community, physicochemical...
To investigate the alterations and functions of intrahepatic B (IHB) cells in non-alcoholic fatty liver disease (NAFLD) model induced by high-fat diet (HFD).C57BL/6 J mice were fed with HFD for 16 weeks to induce NAFLD. Flow cytometry was used analyze lymphocytes from liver, spleen peripheral blood mononuclear (PBMC). Real-time polymerase chain reaction immunofluorescence stain applied cytokine expression IHB cells. CD4(+) T (IHT) enriched a magnetic-activated cell sorting method cultured...
Acute kidney injury (AKI) is a common renal dysfunction.Renal ischemia-reperfusion (I/R) contributes to AKI progression.The microRNA miR-195-5p can act as crucial tumor inhibitor in various cancers.However, the potential biological effects of on are not well-understood.We found that levels were decreased serum samples patients with AKI.Next, we determined expression tissues rats and it was downregulated.Renal function evaluated confirmed using blood urea nitrogen Cr levels.In parallel,...
Renal ischaemia-reperfusion (RI/R) injury is one major pathological state of acute kidney (AKI) with a mortality rate ranking 50% to 80%. MiR-144-5p acts as molecular trigger in various diseases. We presumed that miR-144-5p might be involved RI/R progression. found decreased expression rat models. downregulation promoted cell apoptosis and activated Wnt/β-catenin signal rats. By performing bioinformatic analysis, RIP, RNA pull-down, luciferase reporter experiments, we circ-AKT3 sponged its...