A5101983657- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Functional Brain Connectivity Studies
- Mental Health Research Topics
- Cancer-related cognitive impairment studies
- Neural and Behavioral Psychology Studies
- Treatment of Major Depression
- Heart Failure Treatment and Management
- Obsessive-Compulsive Spectrum Disorders
- Urban Green Space and Health
- Cardiomyopathy and Myosin Studies
- Employment and Welfare Studies
- Cardiovascular Effects of Exercise
- Workplace Health and Well-being
- Mind wandering and attention
- Transcranial Magnetic Stimulation Studies
- Mental Health Treatment and Access
- Pulmonary Hypertension Research and Treatments
- Psychosomatic Disorders and Their Treatments
- COVID-19 and Mental Health
- Health, psychology, and well-being
- Neuroscience and Music Perception
- Electroconvulsive Therapy Studies
- Neurological diseases and metabolism
- Music Therapy and Health
- Neurological disorders and treatments
Anhui Medical University
2014-2025
Bengbu Medical College
2018-2025
Jiaxing University
2020-2025
Tongji University
2013-2024
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2024
University of Electronic Science and Technology of China
2024
University of Hong Kong
2024
Chinese University of Hong Kong
2024
Shanghai Tenth People's Hospital
2013-2024
Sichuan Agricultural University
2020-2024
Abstract Chimeric antigen receptor (CAR)‐T cell immunotherapy is approved in the treatment of hematological malignancies, but remains far from satisfactory solid tumor due to inadequate intra‐tumor CAR‐T infiltration. Herein, an injectable supramolecular hydrogel system, based on self‐assembly between cationic polymer mPEG‐PCL‐PEI (PPP) conjugated with T targeting anti‐CD3e f(ab')2 fragment and α‐cyclodextrin (α‐CD), designed load plasmid CAR (pCAR) a specific CD2 promoter, which...
Abstract Oral mucositis (OM) is the most common and refractory complication of cancer chemotherapy radiotherapy, severely affecting patients’ life quality, lowering treatment tolerance, discouraging patient compliance. Current OM delivery systems mostly affect comfort use lead to poor compliance unsatisfactory effects. Herein, salivary amylases (SAs)‐responsive buccal tablets consisting porous manganese‐substituted Prussian blue (PMPB) nanocubes (NCs), anti‐inflammatory apremilast (Apr)...
Moyamoya disease (MMD) is a rare cerebral vasculopathy characterized by bilateral internal carotid artery stenosis and often leads to stroke in children or young adults. Although familial inheritance well recognized, the genetic basis of MMD remains poorly understood.A 2-stage genome-wide association study was conducted involving 1492 cases 5084 controls. In discovery stage, logistic regression used test associations, imputation based on genotyped single-nucleotide polymorphisms (SNPs)....
Obsessive-compulsive disorder (OCD) affects ∼1 to 3% of the world's population. However, neural mechanisms underlying excessive checking symptoms in OCD are not fully understood. Using viral neuronal tracing mice, we found that glutamatergic neurons from basolateral amygdala (BLAGlu) project onto both medial prefrontal cortex glutamate (mPFCGlu) and GABA (mPFCGABA) locally innervate mPFCGlu neurons. Next, developed an mouse model with quinpirole-induced repetitive behaviors. This...
Abstract Chronic disease, mental health symptoms and poor social relations are reported common causes for self-rated in older people. To assess the co-occurrence rate of chronic diseases, relationships people, determine their association with health. 6,551 people Zhongshan, China, participated a large surveillance program were randomly selected questioned about SRH, conditions, relationships. The between health, relationships, analyzed. 56.4% participants 39.1% experienced at least one...
Virtual urban green environment images and audio stimuli had been proven to have restorative effects on subjects’ physical mental health. In this area, researchers predominantly focused visual, auditory olfactory aspects, while tactile gustatory senses minimally explored. However, the optimal combination of sensory for promoting recovery remains unclear. Therefore, a simulated stimulation approach involving 240 participants was employed, with 30 individuals included in each eight...
Understanding the impact of CYP2D6 metabolism on paroxetine, a widely used antidepressant, is essential for precision dosing.
We hypothesize that the amplitude of low-frequency fluctuations (ALFF) is involved in altered regional baseline brain function social anxiety disorder (SAD). The aim study was to analyze activity drug-naive adult patients with SAD.We investigated spontaneous and activities by obtaining resting-state functional magnetic resonance imaging data 20 drug-naïve SAD 19 healthy controls. Voxels were used ALFF values using one- two-sample t-tests. A post-hoc correlation clinical symptoms also...
Tamoxifen is the most widely used drug for treating patients with estrogen receptor-sensitive breast cancer. There evidence that cancer treated tamoxifen exhibit cognitive dysfunction. However, underlying neural mechanism remains unclear. The present study aimed to investigate mechanisms working memory deficits in combination functional connectivity changes premenopausal women who received long-term treatment.A total of 31 and 32 matched healthy control participants were included. completed...
To investigate the synergistic effect and its mechanism of ginsenoside-Rg5 in combination with imatinib inhibiting proliferation chronic myeloid leukemia K562 cells. cells were treated imatinib. Cell survival was detected by CCK-8 assay, IC50 calculated separately for each drug. Based on value imatinib, an appropriate concentration gradient selected combination. The two drug analyzed using online software synergy finder. effects single or therapy apoptosis rate cell cycle distribution flow...
Abstract Idiopathic generalized epilepsy (IGE) is a brain network disease, but the location of this and its relevance for treatment remain unclear. We combine locations abnormalities in IGE (131 coordinates from 21 studies) with human connectome to identify an network. validate by showing alignment structural previously identified areas activated epileptiform discharges simultaneous electroencephalogram-functional magnetic resonance imaging. The topography aligns networks involved motor...
<title>Abstract</title> Depression disorder is a global health crisis, due to its high prevalence. Yet clinical treatments are inadequate. Uncovering the neural correlates of depression remission vital step toward developing effective therapies. Using new method termed network mapping, we found that amygdala was commonly modulated by three antidepressant therapies (pharmacotherapy, electroconvulsive therapy, and magnetic seizure therapy) in 16 experiments. This common underlying i) validated...
Stroke volume variation (SVV) has been shown to be a reliable predictor of fluid responsiveness. However, the predictive role SVV measured by FloTrac/Vigileo system in prediction responsiveness was unproven patients undergoing ventilation with low tidal volume.Fifty elective gastrointestinal surgery were randomly divided into two groups: Group C [n(1)=20, (V(t)) = 8 ml/kg, frequency (F) 12/min] and L [n(2)=30, V(t)= 6 F=16/min]. After anesthesia induction, 6% hydroxyethyl starch130/0.4...