A5031339472- Biochemical effects in animals
- Immune Response and Inflammation
- Treatment of Major Depression
- Cholesterol and Lipid Metabolism
- Traumatic Brain Injury and Neurovascular Disturbances
- Acute Ischemic Stroke Management
- Advanced Glycation End Products research
- Neuroendocrine Tumor Research Advances
- MicroRNA in disease regulation
- Stress Responses and Cortisol
- Mental Health Research Topics
- Liver Disease Diagnosis and Treatment
- Platelet Disorders and Treatments
- Blood properties and coagulation
- Glycosylation and Glycoproteins Research
- Monoclonal and Polyclonal Antibodies Research
- Cerebrovascular and Carotid Artery Diseases
- Gut microbiota and health
- GABA and Rice Research
- Lung Cancer Research Studies
- Fibroblast Growth Factor Research
- Autophagy in Disease and Therapy
- Extracellular vesicles in disease
- Sinusitis and nasal conditions
- Asthma and respiratory diseases
Zhejiang Chinese Medical University
2024
North Sichuan Medical University
2024
University of Science and Technology of China
2024
Affiliated Hospital of Southwest Medical University
2023
Novo Nordisk (Denmark)
2014
Thomas Jefferson University
1995
Inflammatory bowel diseases (IBD), such as severe colitis, are associated with the development of lung inflammation and tissue damage. Pueraria lobata (P. lobata) plays an essential role in controlling cytokines. However, exact mechanism response is still unknown. Purpose: To investigate effects P. lobata-derived exosomes-like nanovesicles (PLDENs) on colitis their inflammatory response. In this study, we investigated PLDENs dextran sulfate sodium (DSS)-induced explored mechanisms by forming...
Understanding the impact of CYP2D6 metabolism on paroxetine, a widely used antidepressant, is essential for precision dosing.
Preclinical evidence supports targeting the C5a receptor (C5aR) in rheumatoid arthritis (RA). To support ongoing clinical development of an anti-C5aR monoclonal antibody, we have investigated for first time mechanism action and pharmacodynamics a blocking anti-murine C5aR (anti-mC5aR) surrogate antibody mouse collagen-induced (CIA). First, efficacy was demonstrated multiple-dose treatment study. Almost complete inhibition disease progression obtained, including reduced bone cartilage...
Long-term exposure to hyperglycemic conditions leads β-cell dysfunction, particularly mitochondrial and inflammatory oxidative stress responses, which are considered the primary causes of death hallmarks diabetes. Plant-active ingredients may play a key role in glycemic control. Epigallocatechin gallate (EGCG) is characteristic catechin derived from tea that possesses anti-diabetic properties. Nonetheless, its underlying mechanisms remain elusive. Herein, protective EGCG on high glucose (33...