A5060222721- Immune Cell Function and Interaction
- Ginseng Biological Effects and Applications
- Osteoarthritis Treatment and Mechanisms
- Natural product bioactivities and synthesis
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- Bone Metabolism and Diseases
- Cholesterol and Lipid Metabolism
- Genomics, phytochemicals, and oxidative stress
North Sichuan Medical University
2024
Shanxi Medical University
2022-2023
Ginsenoside 24-hydroxy-ginsengdiol (24-OH-PD), extracted from red ginseng, is a novel diol-type ginsenoside, strongly inhibits the growth of human T-cell acute lymphoblastic leukaemia (T-ALL) CCRF-CEM cells. Our research aimed at investigating mechanism underlying this inhibition. Cell viability was determined using cell counting kit-8 (CCK-8) assay, and NOD/SCID mice bearing cells were used to verify therapeutic effect 24-OH-PD on T-ALL in vivo . We equally analysed pathways related RNA-Seq...
Traditional Chinese orthopedics has a long history and excellent clinical effects in the treatment of osteoarthritis (OA). Bushen Tongluowan (BSTLW) is representative prescription based on "kidney governing bones" theory medicine. However, molecular mechanism underlying its effect articular chondrocytes remains unclear. In this study, we investigated BSTLW primary analyzed gene expression after drug using RNA-Seq. The results showed that significantly improved chondrocyte proliferation...