A5059343269- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Cancer-related Molecular Pathways
- Cancer Genomics and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Epigenetics and DNA Methylation
- Tracheal and airway disorders
- Vascular Anomalies and Treatments
- Sphingolipid Metabolism and Signaling
- Immunotherapy and Immune Responses
- Aldose Reductase and Taurine
- Genetics and Neurodevelopmental Disorders
- Autophagy in Disease and Therapy
- Diet, Metabolism, and Disease
- Biological Activity of Diterpenoids and Biflavonoids
- Endoplasmic Reticulum Stress and Disease
- Hippo pathway signaling and YAP/TAZ
- Cancer, Hypoxia, and Metabolism
- PARP inhibition in cancer therapy
- Cytomegalovirus and herpesvirus research
- Genomics and Chromatin Dynamics
- Natural product bioactivities and synthesis
- DNA Repair Mechanisms
- RNA modifications and cancer
Fudan University Shanghai Cancer Center
2020-2025
Affiliated Hospital of North Sichuan Medical College
2024
Guangzhou University of Chinese Medicine
2021-2023
Renmin Hospital of Wuhan University
2023
Wuhan University
2023
Shanghai Medical College of Fudan University
2020
Shenzhen Second People's Hospital
2019
Second Military Medical University
2016
Shenzhen Third People’s Hospital
2013
Guangdong Medical College
2013
MORC family CW-type zinc finger 2 (MORC2) is an oncogenic chromatin-remodeling enzyme with emerging role in DNA repair. Here, we report a novel function for MORC2 cell-cycle checkpoint control through acetylation-dependent mechanism. acetylated by the acetyltransferase NAT10 at lysine 767 (K767Ac) and this process counteracted deacetylase SIRT2 under unperturbed conditions. DNA-damaging chemotherapeutic agents ionizing radiation stimulate K767Ac enhancing interaction between NAT10. Notably,...
Abstract The remarkable advances in next-generation sequencing technology have enabled the wide usage of as a clinical tool. To promote advance precision oncology for breast cancer China, here we report large-scale prospective program using Fudan-BC panel, and comprehensively analyze genomic characteristics Chinese cancer. mutational landscape 1,134 cancers reveals that most significant differences between Western patients occurred hormone receptor positive, human epidermal growth factor 2...
Triple-negative breast cancer (TNBC) is the most aggressive subtype of with poor prognosis. TNBCs high homologous recombination deficiency (HRD) scores benefit from DNA-damaging agents, including platinum drugs and poly(ADP-ribose) polymerase (PARP) inhibitors, whereas those low HRD still lack therapeutic options. Therefore, we sought to exploit metabolic alterations induce sensitize agents in scores. We systematically analyzed TNBC metabolomics identified a metabolite, guanosine diphosphate...
Hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-) breast cancer is the most common type of cancer, with continuous recurrence remaining an important clinical issue. Current relapse predictive models in HR+/HER2- patients still have limitations. The integration multidimensional data represents a promising alternative for predicting relapse. In this study, we leverage our multi-omics cohort comprising 579 (200 complete across 7 modalities) and develop...
Stress granules (SGs) could be formed under different stimulation to inhibit cell injury.To investigate whether SGs protect hepatocytes from hypoxia-induced damage during acute liver failure (ALF) by reducing endoplasmic reticulum stress (ERS) mediated apoptosis.The agonist of SGs, arsenite (Ars) was used intervene hepatocyte injury cellular model and ALF mice models. Further, the siRNA activating transcription factor 4 (ATF4) inhibitor anisomycin then in models.With increase hypoxia time h...
Herein, we describe the discovery of potent and highly selective inhibitors both CDK4 CDK6 via structure-guided optimization a fragment-based screening hit. X-ray crystallography pharmacokinetic data steered efforts in identifying compound 6, which showed >1000-fold selectivity for over CDKs 1 2 an enzymatic assay. Furthermore, 6 demonstrated vivo inhibition pRb-phosphorylation oral efficacy Jeko-1 mouse xenograft model.
Abstract Background We established a radiogenomic model to predict pathological complete response (pCR) in triple-negative breast cancer (TNBC) and explored the association between high-frequency mutations drug resistance. Methods From April 2018 September 2019, 112 patients who had received neoadjuvant chemotherapy were included. randomly split study population into training validation sets (2:1 ratio). Contrast-enhanced magnetic resonance imaging scans obtained at baseline after two cycles...
Lipid accumulation, oxidative stress, and inflammation in hepatocytes are features of nonalcoholic fatty liver disease (NAFLD). Garcinia biflavonoid 1a (GB1a) is a natural product capable hepatic protection. In this study, the effect GB1a on anti-inflammatory, antioxidant, regulation accumulation HepG2 cells mouse primary (MPHs) was investigated, its regulatory mechanism further explored. The result showed that reduced triglyceride (TG) content lipid by regulating expression SREBP-1c PPARα;...
Garcinia biflavonoid 1 (GB1) is one of the active chemical components kola and reported to be capable reducing intracellular lipid deposition, which most significant characteristic non-alcoholic fatty liver disease. However, its bioactive mechanism remains elusive. In current study, deposition was induced in HepG2 cells by exposure oleic acid palmitic (OA&PA), then effect GB1 on metabolism oxidative stress role regulating PPARα these investigated. We found that could ameliorate triglycerides...
Hepatoma Research is an open access journal and focuses on all topics related to hepatoma. The following articles are especially welcome: pathogenesis, clinical examination early diagnosis of hepatoma, complications their preventions treatments, etc.