A5017552936- Histone Deacetylase Inhibitors Research
- Cancer-related Molecular Pathways
- Hippo pathway signaling and YAP/TAZ
- Cancer Genomics and Diagnostics
- Advanced Breast Cancer Therapies
- Epigenetics and DNA Methylation
- Cancer Mechanisms and Therapy
- PI3K/AKT/mTOR signaling in cancer
- Cytomegalovirus and herpesvirus research
- PARP inhibition in cancer therapy
- Ubiquitin and proteasome pathways
- Ovarian function and disorders
- Medical Imaging Techniques and Applications
- Breast Implant and Reconstruction
- Reconstructive Facial Surgery Techniques
- Cancer-related molecular mechanisms research
- Redox biology and oxidative stress
- Reconstructive Surgery and Microvascular Techniques
- Estrogen and related hormone effects
- Mechanisms of cancer metastasis
- Protein Degradation and Inhibitors
- Immunotherapy and Immune Responses
- Statistical Methods in Clinical Trials
- Reproductive Biology and Fertility
- Radiomics and Machine Learning in Medical Imaging
Shanghai Medical College of Fudan University
2024
Fudan University Shanghai Cancer Center
2015-2024
University of Palermo
2024
National Natural Science Foundation of China
2015
Fudan University
2008
Estrogen receptor-positive (ER+) breast cancers represent approximately two-thirds of all and have a sustained risk late disease recurrence. Cyclin-dependent kinase 4 6 (CDK4/6) inhibitors shown significant efficacy in ER+ cancer. However, their effects are still limited by drug resistance. In this study, we aim to explore the role long noncoding RNA TROJAN cancer.The expression level cancer tissue cell lines was determined quantitative real-time PCR. vitro vivo assays as well patient...
Triple-negative breast cancer (TNBC) is the most aggressive subtype of with poor prognosis. TNBCs high homologous recombination deficiency (HRD) scores benefit from DNA-damaging agents, including platinum drugs and poly(ADP-ribose) polymerase (PARP) inhibitors, whereas those low HRD still lack therapeutic options. Therefore, we sought to exploit metabolic alterations induce sensitize agents in scores. We systematically analyzed TNBC metabolomics identified a metabolite, guanosine diphosphate...
The study of this is to assess the current status and trend application breast reconstruction in China. A retrospective review all patients who had received surgical treatment for cancer Fudan University Shanghai Cancer Center between January 1999 June 2014 was performed. clinicopathological epidemiological parameters follow-up information each patient were collected. total 20,551 with 20,974 surgeries identified. Of those, rates mastectomy, conserving therapy, 81.2% (17,040 cases), 15.3%...
Background: With our growing insight into the molecular heterogeneity and biological characteristics of breast cancer, individualized treatment is future cancer treatment. In this prospective Fudan University Shanghai Cancer Center Breast Precision Platform Series study – neoadjuvant therapy (FASCINATE-N) trial, we classify patients using multiomic different subtypes to evaluate efficacy precision-based targeted therapies compared standard chemotherapy. Methods design: The FASCINATE-N trial...
Despite the high prevalence of mammographic calcifications, our understanding remains limited regarding clinical and molecular features calcifications within triple-negative breast cancer (TNBC). To investigate relevance biological basis TNBC with suspicion for malignancy, we established a study cohort (N = 312) by integrating records data genomic, transcriptomic, metabolomic profiling. similar clinicopathological features, patients highly suspicious exhibited worse overall survival than...
<p>Supplementary Data</p>
<p>Supplementary Data</p>
<p>PDF file - 250K, The expression of EMT marker in MDA-MB-231 and MCF-7 cells</p>
Abstract Here, we prospectively collected what is currently the largest Chinese breast cancer cohort of 1,143 patients for clinical sequencing and performed integrated analysis their genomic characteristics. All samples were via needle biopsy. A custom-designed genetic panel was used in this study. The a hybridization capture-based assay, including 484 genes that are targets approved experimental therapies as well frequently mutated cancer. designed detecting mutations small insertions...