A5002256272- Cancer Research and Treatments
- Hippo pathway signaling and YAP/TAZ
- Click Chemistry and Applications
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Breast Cancer Treatment Studies
- Cancer Cells and Metastasis
- Computational Drug Discovery Methods
- Peptidase Inhibition and Analysis
- Circular RNAs in diseases
- Ubiquitin and proteasome pathways
- BRCA gene mutations in cancer
- MicroRNA in disease regulation
- Microtubule and mitosis dynamics
- Advanced Breast Cancer Therapies
- interferon and immune responses
- Chemical Reactions and Isotopes
- Immune cells in cancer
- Estrogen and related hormone effects
- RNA Research and Splicing
- Glioma Diagnosis and Treatment
- Cancer Treatment and Pharmacology
Northeastern University
2024-2025
Guangzhou University of Chinese Medicine
2025
Qinhuangdao Science and Technology Bureau
2025
Nagoya City University
2025
Sun Yat-sen University
2019-2024
The First Affiliated Hospital, Sun Yat-sen University
2019-2024
Bridge University
2022
University of Macau
2022
Army Medical University
2021
Southwest Hospital
2021
Abstract Long non‐coding RNAs (lncRNAs) take various effects in cancer mostly through sponging with microRNAs (miRNAs). lncRNA NR2F1‐AS1 is found to promote tumour progression hepatocellular carcinoma, endometrial and thyroid cancer. However, the role of breast angiogenesis remains unknown. In this study, we was positively related CD31 CD34 Pearson's correlation analysis, while transfection promoted human umbilical vascular endothelial cell (HUVEC) tube formation. cells, enhanced HUVEC...
Abstract Introduction Cancer‐associated fibroblasts (CAFs) are correlated with the immunotherapy response. However, culprits that link CAFs to resistance still rarely investigated in real‐world studies. Objectives This study aims systematically assess landscape of cancer patients by combining single‐cell and bulk profiling data from pan‐cancer cohorts. We further sought decipher expression, survival predictive value association response biglycan (BGN), a proteoglycan extracellular matrix,...
Emotion recognition in conversation (ERC) is an important research direction the field of human-computer interaction (HCI), which recognizes emotions by analyzing utterance signals to enhance user experience and plays role several domains. However, existing on ERC mainly focuses constructing graph networks directly modeling interactions multimodal fused features, cannot adequately capture complex dialog dependency based time, speaker, modalities, etc. In addition, multi-task learning...
Background: A need exists for effective treatments prostate cancer (PCA) due its re-emergence following androgen deprivation therapy, a major clinical problem. In previous study, we presented evidence on the chemopreventive and chemotherapeutic potential of luteolin, flavonoid, in PCA including castration-resistant PCA. this single-arm phase I clinically examined safety oral intake luteolin patients under active surveillance (AS). Methods: Between March September 2022, five with...
Breast cancer (BC) is one of the most common female cancers, and its incidence has been increasing in recent years.Although treatments are continuously improving, prognosis patients advanced stage still unsatisfactory.Thus, an in-depth understanding molecular mechanisms necessary for curing breast cancer.KIF15 a tetrameric spindle motor which can regulate mitosis cellular process exert crucial functions several cancers.The purpose our research was to investigate KIF15 cancer.We tested...
Abstract Cancer metastasis is an extremely complex process affected by many factors. An acidic microenvironment can drive cancer cell migration toward blood vessels while also hampering immune activity. Here, we identified a mechanism mediated sialyltransferases that induces tumor-permissive (ATPME) in BRCA1-mutant and most BRCA1-low breast cancers. Hypersialylation ST8SIA4 perturbed the mammary epithelial bilayer structure generated ATPME immunosuppressive with increased PD-L1 PD1...
Transgelin 2 (TAGLN2) is a cytoskeletal protein of the calponin family. Abnormal expression TAGLN2 was observed in various types cancer. Our previous study reported that reduced lymph node‑positive breast cancer patients; however, role metastasis remains unknown. In present study, investigated vitro and vivo via Transwell migration, luciferase flow cytometry assays, mouse xenograft model. Proteins interacting with were identified co‑immunoprecipitation assays liquid chromatography/mass...
Abstract Tamoxifen resistance remains a clinical problem in estrogen receptor (ER)-positive breast cancer. SUMOylation of ERα enhances ERα-induced transcription activity. Tripartite motif-containing (TRIM) proteins are new class SUMO E3 ligases, which regulate the proteins. However, precise molecular mechanism and function TRIM3 response to tamoxifen remain unclear. In present study, we observed that was dramatically overexpressed cancer, correlated with resistance. Furthermore,...
Background: Long noncoding RNAs (lncRNAs) substantially affect tumor metastasis and are aberrantly expressed in various cancers.However, its role breast cancer (BC) remains unclear.Methods: A microarray assay of differentially lncRNAs epithelial-mesenchymal transition (EMT) non-EMT cells was performed.The prognostic value lnc NR2F1-AS1 expression patients with BC analyzed using The Cancer Genome Atlas database.Lnc levels different cell lines were assessed quantitative real-time PCR.The...
Abstract Background Sustaining proliferation is the most fundamental step for breast cancer tumor genesis. Accelerated usually linked to uncontrolled cell cycle. However, internal and external factors activation of cycle are still be investigated. Methods quantitative PCR (qPCR) Western blotting assay were used detect expression potassium channel tetramerization domain containing 12 (KCTD12) in cancer. MTT colony formation assays performed evaluate effect KCTD12 on Anchorage‐independent...
Metastasis is a major factor weakening the long-term survival of breast cancer patients. Increasing evidence revealed that long non-coding RNAs (lncRNAs) were involved in occurrence and development cancer. In this study, we aimed to investigate role LGALS8-AS1 metastatic progression cells its potential mechanisms.The lncRNA was highly expressed associated with poor survival. functioned as an oncogenic promoted metastasis both vitro vivo. It upregulated SOX12 via competing endogenous RNA...
Clinical significance and biological functions of the ferroptosis pathway were addressed in all aspect cancer regarding multi-omics level; however, overall status alteration was hard to evaluate. The aim this study is comprehensively analyze putative biological, pathological, clinical breast on a level. By adopting bioinformatic algorithm "pathifier", we quantified five programmed cell death (PCD) pathways (KO04210 Apoptosis; KO04216 Ferroptosis; KO04217 Necroptosis; GO:0070269 Pyroptosis;...
// Min He 1,4 , Xin Hu 1 Li Chen A-Yong Cao Ke-Da Yu Ting-Yan Shi 2 Xia-Ying Kuang Wen-Biao Hong Ling Shan Feng Qiao Yao Qingyi Wei 3,5 Gen-Hong Di and Zhi-Ming Shao 1,3,4 Department of Breast Surgery, Key Laboratory Cancer in Shanghai, Fudan University Shanghai Center, China Gynecologic Oncology, 3 Institute, 4 Medical College, University, 5 Duke Durham, NC, United States America Correspondence: Shao, email: Hu, Keywords : XRCC4, homozygous variant, nuclear localization, susceptibility,...
<p>All supplementary tables in one excel file</p>
<p>Original picture</p>
<p>All supplementary tables in one excel file</p>
<p>Original picture</p>
<p>Original picture</p>
<p>supp. figure legends S1-S7</p>
<p>Original picture</p>
<p>Original picture</p>