A5006942783- Neuroblastoma Research and Treatments
- Chemical Synthesis and Analysis
- Wnt/β-catenin signaling in development and cancer
- RNA modifications and cancer
- Cancer Mechanisms and Therapy
- Signaling Pathways in Disease
- Epigenetics and DNA Methylation
- Cell Adhesion Molecules Research
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Cancer Cells and Metastasis
- Circular RNAs in diseases
- Microtubule and mitosis dynamics
- RNA Research and Splicing
- Angiogenesis and VEGF in Cancer
- Animal Genetics and Reproduction
- Expert finding and Q&A systems
- Cancer-related Molecular Pathways
- Neurofibromatosis and Schwannoma Cases
- Knowledge Management and Sharing
- Renin-Angiotensin System Studies
- Cancer, Hypoxia, and Metabolism
- Muscle and Compartmental Disorders
- Pluripotent Stem Cells Research
- Biocrusts and Microbial Ecology
Guangzhou Medical University
2001-2025
First Affiliated Hospital of Kunming Medical University
2023
Kunming Medical University
2023
Nanjing University of Finance and Economics
2023
The First Affiliated Hospital, Sun Yat-sen University
2019-2021
Sun Yat-sen University
2019-2021
Nanjing University
2013-2020
Nanjing Medical University
2020
Nanjing General Hospital of Nanjing Military Command
2017-2018
Breast cancer angiogenesis is key for metastasis and predicts a poor prognosis. Angiotensin-converting enzyme 2 (ACE2), as member of the renin-angiotensin system (RAS), was reported to restrain progression hepatocellular carcinoma (HCC) non-small cell lung (NSCLC) through inhibiting angiogenesis. However, relationship between ACE2 breast remains unclear.The prognosis relative gene selection were analysed using GEPIA, GEO, TCGA STRING databases. expression in tissue estimated by reverse...
Kinesin superfamily (KIFs) has a long-reported significant influence on the initiation, development, and progress of breast cancer. However, prognostic value whole family members was poorly done. Our study intends to demonstrate kinesin as biomarkers well therapeutic target cancer.Comprehensive bioinformatics analyses were done using data from TCGA, GEO, METABRIC, GTEx. LASSO regression select tumor-related members. Nomogram constructed predict overall survival (OS) cancer patients....
Several studies have shown an important role for long non‐coding RNA (lnc ) in breast cancer progression. The present study investigated the of lnc Opa interacting protein 5‐antisense 1 ( OIP 5‐ AS 1) progression cancer. was significantly upregulated tissues and cell lines, downregulation inhibited malignant behavior vitro vivo. For in‐depth exploration mechanism cancer, we found that expression microRNA‐129‐5p(miR‐129‐5p), which to bind sites sequence 1, negatively correlated with 1. Also,...
Background: Increasing evidence has demonstrated that microRNAs play a critical role in breast cancer (BC) progression. microRNA-101 (miR-101) been considered tumor suppressive miRNA different types. This study aimed to investigate miR-101 expression BC tissues and its roles progression are mediated by Sex-determining region Y-box 2 (SOX2), oncogene various cancers. Methods: qRT-PCR immunohistochemistry were performed detect SOX2 paired normal or cell lines. MTT, transwell migration, wound...
Abstract Neuroblastoma (NB) is a common malignant and solid pediatric tumor with unfavorable prognosis. Although studies have shown the anti-tumor efficacy of lentinan (LNT), molecular mechanism that contribute to effect on NB remains unclear. The aim this study unmask role LNT in specific mechanism. At first, vivo experiments were conducted results indicated could suppress growth NB. Subsequent cellular functional assays unveiled treatment efficiently decrease cell viability, induce cycle...
Breast cancer (BC) is one of the most common female cancers, and its incidence has been increasing in recent years.Although treatments are continuously improving, prognosis patients advanced stage still unsatisfactory.Thus, an in-depth understanding molecular mechanisms necessary for curing breast cancer.KIF15 a tetrameric spindle motor which can regulate mitosis cellular process exert crucial functions several cancers.The purpose our research was to investigate KIF15 cancer.We tested...
Abstract Increasing studies have pointed out that small nucleolar RNAs (snoRNAs) and their host genes (SNHGs) multi-functional roles in cancer progression. Bioinformatics analysis revealed the importance of snoRNA gene 25 (SNHG25) neuroblastoma (NB). Hence, we further explored function molecular mechanism SNHG25 NB. Our study expression was upregulated NB cells. Through loss-of-function assays, discovered silencing suppressed cell proliferation, invasion, migration. Moreover, found...
Abstract Tamoxifen resistance remains a clinical problem in estrogen receptor (ER)-positive breast cancer. SUMOylation of ERα enhances ERα-induced transcription activity. Tripartite motif-containing (TRIM) proteins are new class SUMO E3 ligases, which regulate the proteins. However, precise molecular mechanism and function TRIM3 response to tamoxifen remain unclear. In present study, we observed that was dramatically overexpressed cancer, correlated with resistance. Furthermore,...
Abstract Background Sustaining proliferation is the most fundamental step for breast cancer tumor genesis. Accelerated usually linked to uncontrolled cell cycle. However, internal and external factors activation of cycle are still be investigated. Methods quantitative PCR (qPCR) Western blotting assay were used detect expression potassium channel tetramerization domain containing 12 (KCTD12) in cancer. MTT colony formation assays performed evaluate effect KCTD12 on Anchorage‐independent...
The sex-determining region Y‑box 2 (SOX2) gene, a member of the Sry‑like high-mobility group box (SOX) gene family, encodes transcription factor Sox2, which significantly contributes to regulation cell pluripotency. Sox2 is closely associated with early embryonic development, neural differentiation and other biological processes. An inreasing number recent studies suggest that exerts positive effect on malignant tumors. According these results, expected become novel target for cancer therapy...
Cancer metastasis remains a major challenge for the clinical management of breast cancer, especially triple-negative cancer (TNBC), and underlying molecular mechanisms remain largely unknown. The aim this study was to explore mechanism TNBC metastasis.The expression protein tyrosine phosphatase, non-receptor type 7 (HePTP) detected using real time-PCR, western blot. Wound healing assay transwell matrix were used evaluate pro-migration pro-invasion potential HePTP in vitro. Luciferase...
Background: RBMS3 (RNA-binding motif, single-stranded-intervacting protein 3) acts as a tumor-suppressive gene in number of human cancers, however, its role breast cancer is not fully understood. This study aimed to investigate the expression and clinicopathological significance cancer. Methods: A total 998 tissue samples The Cancer Genome Atlas (TCGA) database with survival outcomes were divided into high low groups using median cutoff. Clinicopathological characteristics prognosis compared...
Neuroblastoma is a primary malignancy mainly occurring in children. We have reported that polymorphisms of several N6-methyladenosine (m6A) RNA modification-related genes contributed to neuroblastoma risk previous studies. YTHDF2, “reader” m6A modification, involved cancer progression. Here, we estimated the association between YTHDF2 gene rs3738067 A>G polymorphism and susceptibility 898 patients 1,734 healthy individuals from China. found could decrease [AG vs. AA: adjusted odds...
Abstract Background Breast cancer (BC) is one of the commonest female cancers, which characterized with high incidence. Although treatments have been improved, prognosis BC patients in advanced stages remains unsatisfactory. Thus, exploration molecular mechanisms underneath progression necessary to find novel therapeutic methods. Frizzled class receptor 2 (FZD2) belongs family, has proven promote cell growth and invasion various human cancers. The purpose our current study was detect...
Abstract Social Q&A refers to the process of information seeking based on questioning‐and‐answering in natural language through social networks. It facilitates knowledge gathering and interacting, thus can be regarded as an appropriate environment for informal learning. This study intends explore factors affecting continuance intention using communities learning meanwhile reveal underlying mechanism among these factors. Data were obtained from 257 university students online survey. By...
Neuroblastoma (NB) is the most common extracranial malignant solid tumor in children. We found that TTF1, TrkA, and miR-204 were lowly expressed, whereas TrkB was highly expressed undifferentiated NB tissues. Meanwhile, TTF1 expression correlated positively with TrkA but negatively expression. The promoter hypermethylated tissues SK-N-BE cells, leading to downregulation. also identified miR-204, which directly targets TrkB, as a transcriptional target of TTF1. Functionally, suppressed...