A5114803391- Hepatocellular Carcinoma Treatment and Prognosis
- Neuroblastoma Research and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Pediatric Hepatobiliary Diseases and Treatments
- Cancer, Hypoxia, and Metabolism
- Anatomy and Medical Technology
- Adrenal and Paraganglionic Tumors
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Surgical Simulation and Training
- Sarcoma Diagnosis and Treatment
- Educational Games and Gamification
- RNA Research and Splicing
- Viral-associated cancers and disorders
- DNA Repair Mechanisms
- Pleural and Pulmonary Diseases
- Neurofibromatosis and Schwannoma Cases
- Cerebral Palsy and Movement Disorders
- Testicular diseases and treatments
- Teratomas and Epidermoid Cysts
- Intestinal Malrotation and Obstruction Disorders
- Neonatal Health and Biochemistry
- Congenital Anomalies and Fetal Surgery
- Stroke Rehabilitation and Recovery
Guangzhou Medical University
2015-2025
Shanghai Ninth People's Hospital
2024
Shanghai Jiao Tong University
2024
Nanjing University
2024
Nanjing General Hospital of Nanjing Military Command
2024
Twelfth Guangzhou City People's Hospital
2023
Guangzhou Women and Children Medical Center
2015-2020
Tongji University
2019
Chinese Academy of Medical Sciences & Peking Union Medical College
2019
Inner Mongolia Medical University
2012
Objective To investigate the impact of using a three-dimensional (3D) printed liver model for patient education. Methods Children with hepatic tumours who were scheduled hepatectomy enrolled, and patient-specific 3D models photosensitive resin, based on computed tomography (CT) images. Before surgery, their parents received information regarding anatomy, physiology, tumour characteristics, planned surgical risks these CT Then, completed questionnaires this information. Thereafter, each...
Abstract Neuroblastoma (NB) is a common malignant and solid pediatric tumor with unfavorable prognosis. Although studies have shown the anti-tumor efficacy of lentinan (LNT), molecular mechanism that contribute to effect on NB remains unclear. The aim this study unmask role LNT in specific mechanism. At first, vivo experiments were conducted results indicated could suppress growth NB. Subsequent cellular functional assays unveiled treatment efficiently decrease cell viability, induce cycle...
Hepatoblastoma (HB) is the most common hepatic malignancy in children, accounting for approximately 80% of all childhood liver tumors. Previous genome-wide association studies (GWASs) have found that LINC00673 rs11655237 C>T polymorphism associated with risk several different adult cancers. However, between this and HB susceptibility remains unclear.We analyzed a hospital-based study Chinese children. We enrolled 213 patients 958 healthy controls genotypes determined by TaqMan, strength...
Abstract Background H19 polymorphisms have been reported to correlate with an increased susceptibility a few types of cancers, although their role in neuroblastoma has not yet clarified. Materials and methods We investigated the association between three single (rs2839698 G>A, rs3024270 C>G, rs217727 G>A) Chinese Han populations. Three hundred ninety-three patients 812 healthy controls were enrolled from Henan Guangdong provinces. Odds ratios (ORs) 95% confidence...
Abstract Increasing studies have pointed out that small nucleolar RNAs (snoRNAs) and their host genes (SNHGs) multi-functional roles in cancer progression. Bioinformatics analysis revealed the importance of snoRNA gene 25 (SNHG25) neuroblastoma (NB). Hence, we further explored function molecular mechanism SNHG25 NB. Our study expression was upregulated NB cells. Through loss-of-function assays, discovered silencing suppressed cell proliferation, invasion, migration. Moreover, found...
Hepatoblastoma is the most common hepatic malignancy in children, accounting for approximately 80% of all childhood liver tumors. KRAS and NRAS, members RAS gene family, are closely linked to tumorigenesis, frequently mutated a variety malignancies. They may thus play critical roles tumorigenesis. However, there few studies on association between polymorphisms risk hepatoblastoma. We investigated whether at these genes associated with hepatoblastoma susceptibility hospital-based study 213...
The TP53 gene encodes an important class of cell cycle and tumor-suppressing factors that play critical roles in maintaining genomic stability. Arg72Pro (rs1042522 C>G) polymorphism has been reported to be associated with the risk several types adult cancers; however, its for pediatric cancers remains unclear. Here, we analyzed association rs1042522 C>G hepatoblastoma (HB) susceptibility a hospital-based study among Chinese children. A total 213 HB patients 958 healthy controls were enrolled...
Abstract H19 polymorphisms are associated with increased susceptibility to several cancers; however, their role in hepatoblastoma remains unclear. In this study, we investigated the association between three (rs2839698 G>A, rs3024270 C>G, rs217727 G>A) and 213 patients. The rs2839698 were significantly risk, GG genotype a higher risk of than CC at locus. polymorphism was decreased AG lower genotype. These findings confirmed by combined analysis, stratification analysis revealed that...
Abstract Background To report the outcomes of hepatoblastoma resected in our institution. Methods We diagnosed 135 children with at institution between January 2010 and December 2017. Patients who underwent liver resection were included for analysis. However, patients abandoned treatment after diagnosis excluded from analysis, but their clinical characteristics provided supplementary material. Results Forty-two treatment, whereas 93 statistical Thirty-six, 23, 3, 31 had PRETEXT stages II,...
Craniofacial structure and dental hard tissue used to be researched on by traditional imaging tools such as light microscope, electron microscope micro-CT. Due the limitations of principle, resolution 3D rendering reconstruction technique, are constrained for presenting fine precise measurements. Here a brand-new equipment-3D X-ray is introduced realize more efficient scanning demonstrating comparison craniofacial structures diabetes normal DBA mouse. To explore higher resolution,...
Background. Little is known about the induction of functional and brain structural reorganization in hemiplegic cerebral palsy (HCP) by constraint-induced movement therapy (CIMT). Objective. We aimed to explore specific molecular mechanism plasticity related CIMT HCP. Methods. The mice were divided into a control group HCP groups with different interventions (unconstraint-induced [UNCIMT], or siRNA-Nogo-A [SN] treatment): HCP, HCP+UNCIMT, HCP+CIMT, HCP+SN, HCP+SN+CIMT groups. Rotarod...
The rs2147578 C > G polymorphism in the long non-coding RNA gene Lnc-LAMC2-1:1 is associated with increased susceptibility to a few types of cancers. However, its role neuroblastoma has not been evaluated yet.We investigated association between lnc-LAMC2-1:1 and Chinese Han populations. A total 393 cases 812 healthy individuals from Henan Guangdong provinces were enrolled subjected genotyping. Odds ratio (OR) 95% confidence interval (CI) used determine strength interest.Combined analysis...
Traditionally, ruptured hepatoblastoma is considered a high-risk occurrence, necessitating chemotherapy regimen usually consisting of cisplatin alternating with carboplatin plus doxorubicin, based on International Childhood Liver Tumours Strategy Group studies. However, hepatoblastomas intact hepatic capsules may represent unique subgroup that be successfully treated TAE, monotherapy, and surgical excision. We herein present case (pretreatment tumor extension stage II) in 1-year-old female...
Neuroblastoma is one of the most common malignant tumors in childhood. Polymorphisms proto-oncogene MYC are implicated many cancers, although their role neuroblastoma remains unclear. In present study, we attempted to investigate association between gene polymorphisms and susceptibility Chinese children.We included two (rs4645943 rs2070583) assessed effects on risk 505 cases 1070 controls via Taqman method.In single combined locus analysis, no significant was found selected susceptibility....
Neuroblastoma (NB) is the most common extracranial malignant solid tumor in children. We found that TTF1, TrkA, and miR-204 were lowly expressed, whereas TrkB was highly expressed undifferentiated NB tissues. Meanwhile, TTF1 expression correlated positively with TrkA but negatively expression. The promoter hypermethylated tissues SK-N-BE cells, leading to downregulation. also identified miR-204, which directly targets TrkB, as a transcriptional target of TTF1. Functionally, suppressed...
Recent studies have revealed that long non-coding RNAs (lncRNAs) play critical roles in the tumorigenesis and proliferation of human cancer. Several polymorphisms lncRNAs been found to be involved risk neuroblastoma (NB). However, on relationship between lncRNA exons NB are infrequent. We evaluated association rs11752942 A > G polymorphism lnc-RNA-uc003opf.1 exon susceptibility by performing a hospital-based study with 275 patients 531 controls. Odds ratios (ORs) 95% confidence intervals...