A5100456672- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA modifications and cancer
- Cancer Cells and Metastasis
- Pluripotent Stem Cells Research
- RNA Research and Splicing
- Cancer Genomics and Diagnostics
- Chemical Synthesis and Analysis
- Epigenetics and DNA Methylation
- Photoacoustic and Ultrasonic Imaging
- Cell Adhesion Molecules Research
- Wnt/β-catenin signaling in development and cancer
- Thermography and Photoacoustic Techniques
- Histone Deacetylase Inhibitors Research
- Plant and Fungal Species Descriptions
- Cytokine Signaling Pathways and Interactions
- Genomics and Phylogenetic Studies
- CRISPR and Genetic Engineering
- Ferroptosis and cancer prognosis
- Ear and Head Tumors
- Cancer, Hypoxia, and Metabolism
- dental development and anomalies
- Renal and related cancers
- Anesthesia and Sedative Agents
Affiliated Hospital of Southwest Medical University
2023-2025
Tianjin Municipal Engineering Design and Research Institute
2025
Nanjing University
2013-2023
Nanjing General Hospital of Nanjing Military Command
2014-2023
Nanjing Maternity and Child Health Care Hospital
2023
Nanjing Medical University
2020-2023
Fuyang Second People's Hospital
2023
Anhui Medical University
2023
Yunnan Academy of Agricultural Sciences
2020-2022
Peking University
2020-2022
Background/Aims: MicroRNAs (miRNAs) play important roles in tumorigenesis. We investigated the and mechanisms of miR-138 human non-small cell lung cancer (NSCLC). Methods: The expression was first examined NSCLC lines tumourtissues by real-time PCR vitro vivo functional effect further. A luciferase reporter assay conducted to confirm target association between enhancer zeste homolog 2 (EZH2). Results: frequently downregulated cells tissues. Overexpression inhibited proliferation tumor growth...
Background: Our previous findings showed that miR-33 expressed abnormally in clinical specimens of melanoma, but the exact molecular mechanism has not been elucidated. Object: To determine miR-33's roles melanoma and confirm whether HIF-1α is a direct target gene miR-33a. Methods: First miR-33a/b expression levels were detected HM, WM35, WM451, A375 SK-MEL-1. Then lentiviral vectors constructed to intervene miR-33a cells. Cell proliferation, invasion metastasis detected. cells mice model was...
Based on the analyzed relationship between microstructure and spectral parameters of photoacoustic signal, a tomography scheme with narrowband low frequency is designed to evaluate subwavelength tissues. Experiments show that this approach can differentiate microstructures two melanomas-like samples, where their structure scales (49 199 μm) are much smaller than working wavelength 0.3–1.5 mm imaging system. Since an effective indicator tissue characteristics, proposed could have potential...
The purpose of this study was to determine the expression miR-127 and analyze its prognostic biological significance in breast cancer (BC). A quantitative reverse transcription PCR assay performed detect 15 pairs BC corresponding noncancerous tissues. detected another 110 tissues correlations with clinicopathological factors patients were examined. Univariate multivariate analyses expression. effects on malignant phenotypes cells possible molecular mechanisms further determined....
Several studies have shown an important role for long non‐coding RNA (lnc ) in breast cancer progression. The present study investigated the of lnc Opa interacting protein 5‐antisense 1 ( OIP 5‐ AS 1) progression cancer. was significantly upregulated tissues and cell lines, downregulation inhibited malignant behavior vitro vivo. For in‐depth exploration mechanism cancer, we found that expression microRNA‐129‐5p(miR‐129‐5p), which to bind sites sequence 1, negatively correlated with 1. Also,...
With the continuous increase in urbanization rate, amount of sewage received by pipe network has also been increasing annually. The phenomenon high water level operation networks emerged many cities, which seriously affects drainage efficiency. Therefore, constructing an effective evaluation method to assess hydraulic performance operating at levels, as well identifying high-risk pipelines, formulating cost-effective rehabilitation schemes, and evaluating effects become necessary solve this...
Pelvic lymph node metastasis is a critical factor influencing prognosis and treatment strategies in cervical cancer patients. This study aimed to identify significant clinical pathological risk factors associated with pelvic patients cancer. We conducted retrospective analysis of 186 treated at the Affiliated Hospital, Southwest Medical University from January 2010 December 2020. Patients were divided into two groups: those (n=40) without (n=146). Data on demographics, characteristics,...
Background: Increasing evidence has demonstrated that microRNAs play a critical role in breast cancer (BC) progression. microRNA-101 (miR-101) been considered tumor suppressive miRNA different types. This study aimed to investigate miR-101 expression BC tissues and its roles progression are mediated by Sex-determining region Y-box 2 (SOX2), oncogene various cancers. Methods: qRT-PCR immunohistochemistry were performed detect SOX2 paired normal or cell lines. MTT, transwell migration, wound...
Abstract To determine the prognostic value of timing circulating breast tumour cell measurement during treatment, peripheral blood from 164 patients with disease was collected. Circulating cells (CTCs) were enriched by using immunomagnetic nanospheres (IMNs) and identified immunofluorescent staining. The CTC shows nuclear-positive, EpCAM-positive, CK19-positive, CD45-negative. Patients positivity (> 19/7.5 mL blood) had shorter progression-free survival (PFS) overall (OS) than those...
Dysregulation of microRNAs (miRNAs) plays critical roles in tumor progression. The aim this study was to investigate the clinicopathologic and prognostic significance miR-497 expression human breast cancer (BC). Taqman qRT-PCR assay performed detect microRNA (miR)-497 30 pairs BC tissues corresponding noncancerous tissues. Additionally, miRNA detected another 128 its correlations with features patients were analyzed. Kaplan-Meier analyses used assess survival patients. Univariate...
Deregulation of the WNT signaling pathway is associated with development and progression breast cancer. β-catenin mutations have been found to constitutively activate β-catenin-T-cell factor (TCF) in other types acetylation regulates β-catenin-TCF4 interaction signaling, but it remains unknown whether involved WNT-induced proliferation cancer cells. In this study, a lower level acetylated (K345) was observed tissues. WNT3A stimulated downregulation promoted MCF7 The K345Q mutation inhibited...
MicroRNAs (miRs) may induce mRNA degradation or inhibit protein translation by directly binding to the 3'-untranslational region of target mRNAs. It has been reported that miR-138 is downregulated in malignant melanoma (MM) cells. However, role MM cell proliferation, invasion and energy metabolism remains unknown. These were investigated using reverse transcription‑quantitative polymerase chain reaction was used evaluate expression hypoxia-inducible factor‑1α (HIF‑1α), as HIF‑1α serves a...
PPP2R5E belongs to the phosphatase 2A regulatory subunit B family and acts as a tumor suppressor in human cancer. However, role of tumorigenesis gastric cancer is unclear. Here, we declare that downregulated by miR‐23a induces cell growth inhibition apoptosis cells. Furthermore, ASO‐miR‐23a suppresses derived from MGC803 cells vivo. identified new target miR‐23a. Moreover, overexpression reversed negative effects We highlight significance proliferation
The abnormal proliferation of vascular smooth muscle cells (VSMCs) plays an important role in the development and progression diabetic complications. In high-glucose (HG) conditions, endothelial (ECs) act as first barrier to damaging stimuli trigger a multi-response, including EC VSMC crosstalk. However, crosstalk pathways between ECs VSMCs under HG conditions remain unclear. This study aimed explore roles underlying mechanism exosomes derived from VSMCs. Our results showed that mouse aortic...
Recently, many Mo deposits genetically related to emplacement of Early Cretaceous granites have been found in the Dabie–Qinling belt. A typical intrusion that combines magmatism and metallogenesis, Bao'anzhai granite, yields a zircon 238U–206Pb age 123.2 ± 1.1 Ma molybdenite Re–Os isochron 122.5 2.7 Ma. This granite is characterized by high silica alkali, but low Mg, Fe, Ca. It enriched with light rare earth elements (REEs) large-ion lithophile (LILEs, Rb, K, Th, U) depleted heavy REEs,...