A5100745312- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA modifications and cancer
- RNA Research and Splicing
- Cancer, Lipids, and Metabolism
- Signaling Pathways in Disease
- Peptidase Inhibition and Analysis
- Cancer, Stress, Anesthesia, and Immune Response
- RNA Interference and Gene Delivery
- Nutrition, Genetics, and Disease
- Extracellular vesicles in disease
- Bladder and Urothelial Cancer Treatments
- Metabolomics and Mass Spectrometry Studies
- Aluminum toxicity and tolerance in plants and animals
- Calpain Protease Function and Regulation
- Liver Disease Diagnosis and Treatment
- Peroxisome Proliferator-Activated Receptors
- Bone Metabolism and Diseases
- Toxin Mechanisms and Immunotoxins
- Carcinogens and Genotoxicity Assessment
- Multiple Myeloma Research and Treatments
- Metabolism, Diabetes, and Cancer
- Neurogenesis and neuroplasticity mechanisms
- Vibrio bacteria research studies
Sichuan University
2016-2025
State Key Laboratory of Biotherapy
2017-2025
Wuhan University
2025
Renmin Hospital of Wuhan University
2025
Xinxiang Medical University
2025
Jilin Medical University
2024
Peking Union Medical College Hospital
2022-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2024
Shaoyang University
2024
West China Hospital of Sichuan University
2022-2024
Background and Aims Tumor metastasis is a major factor of high recurrence mortality in hepatocellular carcinoma (HCC), but its underlying mechanism remains elusive. We report that PDZ LIM domain protein 1 (PDLIM1) significantly down‐regulated metastatic human HCC tissues, which predicts unfavorable prognosis, suggesting PDLIM1 may play an important inhibitory role during metastasis. Approach Results Functional studies indicate knockdown induces epithelial‐to‐mesenchymal transition (EMT)...
Abstract Background Circular RNAs (circRNAs) are differentially expressed between normal and cancerous tissues, contributing to tumor initiation progression. However, comprehensive landscape of dysregulated circRNAs across cancer types remains unclear. Methods In this study, we conducted Ribo-Zero transcriptome sequencing on tissues their adjacent samples including glioblastoma, esophageal squamous cell carcinoma, lung adenocarcinoma, thyroid cancer, colorectal gastric hepatocellular...
Hepatocellular carcinoma (HCC) is a leading cause of cancer death worldwide, but there are few effective treatments. Aberrant microRNA (miRNA) biogenesis correlated with HCC development. We previously demonstrated that peptidyl‐prolyl cis ‐ trans isomerase NIMA‐interacting 1 (Pin1) participates in miRNA and potential treatment target. However, how Pin1 modulates remains obscure. Here, we present vivo evidence overexpression directly linked to the development HCC. Administration inhibitor...
Curcumin has been widely used as a food additive for centuries and recently explored its anti-inflammatory antitumor properties. Although curcumin is pharmacologically safe efficacious to certain cancers, role against acute myeloid leukemia (AML) still remains unclear, it lacks clinical application due low water solubility in vivo bioavailability. To address these issues, we developed novel liposome modified with hyaluronan (HA-Cur-LPs) specifically deliver AML by targeting CD44 on cell...
Ultrasound has attracted great interest of both industry and scientific communities for its potential use as a physical processing preservation tool. In this study, Escherichia coli O157:H7 was selected the model microbe to investigate ultrasound-induced cell death. Slight variations in membrane ion exchanges across induced by low-intensity ultrasound increased permeability E. O157:H7, reversible sublethal effect can preserve viability meanwhile be beneficial bioprocessing application....
The Warburg effect is a promising target for the diagnosis and treatment of cancer, referring to ability cancer cells generate energy through high levels glycolysis even in presence oxygen, allowing them grow proliferate rapidly. antipsychotic Pimozide has strong anti-breast effects both vivo vitro, whether an inhibitory on aerobic not been elucidated. In this study, inhibited breast by hindering glucose uptake, ATP level lactate production; reducing extracellular acidification rate (ECAR);...
Acute myeloid leukemia (AML) is the common blood cancer in hematopoietic system-related diseases and has a poor prognosis. Studies have shown that long non-coding RNAs (lncRNAs) are closely related to pathogenesis of variety diseases, including AML. However, specific molecular mechanism remains unclear. Hence, objective this study was investigate effect lncRNA X inactive transcript (lncRNA XIST) on To achieve our objective, some tests were performed. Quantitative real-time polymerase chain...
Proanthocyanidin-rich grape seed extract (GSE) has been shown to have the potential protect bones, although underlying mechanism remains unknown. The current study aims explore GSE's preventive and therapeutic impact on bone loss induced by oestrogen deficiency through gut microbiota (GM) metabolomic responses. In oestrogen-deficient ovariectomized (OVX) mice, GSE ameliorated inhibiting expansion of marrow adipose tissue (BMAT), restoring BMAT lipolysis promoting formation. regulated...
Nanoplastics (NPs) have attracted widespread attention owing to their presence in the body. Recent studies highlighted detrimental effects of NPs on digestive tract. However, no reported an association between exposure and colitis-associated cancer (CAC). An azoxymethane/dextran sodium sulfate-induced CAC model was used, polystyrene nanoparticles (PS-NPs) were selected for long-term exposure. Non-targeted metabolomics 16S rRNA sequencing used detect changes colonic metabolites gut microbes...
Hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths globally, and the need for effective systemic therapies HCC urgent. Our previous work reveals that Pin1 potential anti-HCC target, which regulates miRNA biogenesis identifies API-1 as novel inhibitor to suppresses HCC. However, great demand in therapy well limited chemical stability pharmacokinetic feature motivated us find improved inhibitors. Herein, we designed synthesized diverse 6-O-benzylguanine derivatives...
MicroRNA (miR)-26 was found to be downregulated in cardiac diseases. In this study, the critical role of miR-26 myocardial hypertrophy both vivo and vitro investigated. Sixteen male Wistar rats that underwent sham or transverse abdominal aortic constriction (TAAC) surgery were divided into control TAAC group. Cardiomyocytes isolated from neonatal Sprague-Dawley rats. Our study demonstrated miR-26a/b rat model cardiomyocytes. The results luciferase assays also suggested glycogen synthase...
Abstract Background Non-small cell lung cancer (NSCLC) includes adenocarcinoma (LUAD) and squamous carcinoma (LUSC). MicroRNA (miRNA) plays an important role in the regulation of post-transcriptional gene expression animals plants, especially adenocarcinoma. Methods MiR-1307-5p is miRNA with significant differences screened by second generation high-throughput sequencing early stage our research group. In current study, a series vitro vivo experiments were carried out. mimic, miR-1307-5p...
Pancreatic Ductal Adenocarcinoma (PDAC) stem cells (CSCs) play a vital role in the occurrence, development and recurrence of PDAC. Previous studies have shown that long non-coding RNAs (lncRNA) are closely associated with occurrence malignant tumors. Among them, LncRNA called homeobox transcription antisense RNA (HOTAIR) plays key cancer progression variety tumors, including Numerous HOTAIR poor prognosis tumor treatment, owing to its regulating downstream microRNAs (miRNAs). However,...