A5101776800- HER2/EGFR in Cancer Research
- Advanced Breast Cancer Therapies
- Computational Drug Discovery Methods
- Radiomics and Machine Learning in Medical Imaging
- Advanced Biosensing Techniques and Applications
- Cancer Genomics and Diagnostics
- Ferroptosis and cancer prognosis
- Breast Cancer Treatment Studies
- Cancer, Lipids, and Metabolism
- PARP inhibition in cancer therapy
- Monoclonal and Polyclonal Antibodies Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Tumors and Oncological Cases
- Air Quality and Health Impacts
- Neonatal and fetal brain pathology
- Pregnancy-related medical research
- Metastasis and carcinoma case studies
- Retinopathy of Prematurity Studies
- Clinical Laboratory Practices and Quality Control
- Cancer Diagnosis and Treatment
- Peroxisome Proliferator-Activated Receptors
- Gastric Cancer Management and Outcomes
- RNA modifications and cancer
- Fungal Infections and Studies
- Cancer Immunotherapy and Biomarkers
Fudan University Shanghai Cancer Center
2018-2025
Shanghai Medical College of Fudan University
2018-2025
Third Affiliated Hospital of Sun Yat-sen University
2022-2025
Sun Yat-sen University
2022-2025
Fudan University
2021-2024
Children's Hospital of Los Angeles
2022-2023
University of Southern California
2022
Nanjing Medical University
2022
Soochow University
2022
Second Affiliated Hospital of Soochow University
2022
An emerging view regarding cancer metabolism is that it heterogeneous and context-specific, but remains to be elucidated in breast cancers. In this study, we characterized the energy-related metabolic features of cancers through integrative analyses multiple datasets with genomics, transcriptomics, metabolomics, single-cell transcriptome profiling. Energy-related signatures were used stratify tumors into two prognostic clusters: cluster 1 exhibits high glycolytic activity decreased survival...
Intratumor heterogeneity (ITH) profoundly affects therapeutic responses and clinical outcomes. However, the widespread methods for assessing ITH based on genomic sequencing or pathological slides, which rely limited tissue samples, may lead to inaccuracies due potential sampling biases. Using a newly established multicenter breast cancer radio-multiomic dataset ( n = 1474) encompassing radiomic features extracted from dynamic contrast–enhanced magnetic resonance images, we formulated...
Triple-negative breast cancer (TNBC) is the most aggressive subtype of with poor prognosis. TNBCs high homologous recombination deficiency (HRD) scores benefit from DNA-damaging agents, including platinum drugs and poly(ADP-ribose) polymerase (PARP) inhibitors, whereas those low HRD still lack therapeutic options. Therefore, we sought to exploit metabolic alterations induce sensitize agents in scores. We systematically analyzed TNBC metabolomics identified a metabolite, guanosine diphosphate...
HER2-positive breast cancer is an aggressive subtype that accounts for 15% to 20% of all cancers. Recent studies have suggested a group heterogeneous diseases with different sensitivities standard treatment regimens. Revealing the molecular heterogeneity could potentially enable more precise strategies. In this study, we performed multiomics profiling on cohort and identified four transcriptome-based subtypes. The classical HER2 (HER2-CLA) comprised 28.3% samples displayed high ERBB2...
Hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-) breast cancer is the most common type of cancer, with continuous recurrence remaining an important clinical issue. Current relapse predictive models in HR+/HER2- patients still have limitations. The integration multidimensional data represents a promising alternative for predicting relapse. In this study, we leverage our multi-omics cohort comprising 579 (200 complete across 7 modalities) and develop...
Triple-negative breast cancer (TNBC) is known for frequent copy number alterations (CNAs) and metabolic reprogramming. However, the mechanism by which CNAs of genes drive distinct reprogramming affect disease progression remains unclear. Through an integrated analysis our TNBC multiomic dataset (n = 465) subsequent experimental validation, we identify amplification gene flavin-adenine dinucleotide synthetase 1 (FLAD1) as a crucial genetic event that drives progression. Mechanistically,...
Background: Pulmonary lymphoepithelioma-like carcinoma (pLELC) is a rare subtype of non-small-cell lung cancer that predominantly affects younger, non-smoking individuals in southern and southeast Asia, where Epstein–Barr virus (EBV) prevalence high. The efficacy safety immunotherapy pLELC, especially second-line settings, remain inadequately explored. Objectives: This study aimed to evaluate the immunotherapy, either alone or combination with chemotherapy, improving progression-free...
Background: Occult breast cancer (OBC) is a rare type of that has not been well studied. The clinicopathological characteristics and treatment recommendations for OBC are based on limited number retrospective studies thus remain controversial. Patients methods: We identified 479 patients 115,739 non-OBC from 2004 to 2014 in the Surveillance, Epidemiology, End Results (SEER) database. survival outcomes were compared between patients. used propensity score 1:1 matching analysis evaluate vs...
Triple-negative breast cancers (TNBCs), especially those non-immune-inflamed tumors, have a poor prognosis and limited therapies. Human leukocyte antigen (HLA)-I not only contributes to antitumor immune response the phenotype of tumor microenvironment, but also is negative predictor outcomes after immunotherapy. However, importance HLA functional status in TNBCs remains poorly understood. Using largest original multiomics datasets on TNBCs, we systematically characterized HLA-Ⅰ from...
<div>Abstract<p>HER2-positive breast cancer is an aggressive subtype that accounts for 15% to 20% of all cancers. Recent studies have suggested HER2-positive a group heterogeneous diseases with different sensitivities standard treatment regimens. Revealing the molecular heterogeneity could potentially enable more precise strategies. In this study, we performed multiomics profiling on cohort and identified four transcriptome-based subtypes. The classical HER2 (HER2-CLA) comprised...
Abstract The associated article reports multiomic analysis of breast cancers, where we provided a unique public resource that contributes novel insights into the cancer, holding promise for further precision treatment approaches. This protocol not only delineates detailed experimental procedures sample preparation and data generation but also comprehensive methods genomics, transcriptomics, proteomics, metabolomics from cancer samples. Furthermore, regarding radiomics pathomics, describes...
The association between exposure to ambient fine particulate matter with an aerodynamic diameter of ≤ 2.5 μm (PM ) and short- medium-term lung function recovery (LFR) in patients undergoing lobectomy remains uncertain. This study investigated the associations PM concentrations LFR adult ( n = 526) who underwent video-assisted thoracoscopic (VATS) Guangzhou, China January 2018 June 2021. All at least two spirometry tests. Environmental same period were collected from nearest monitoring...
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<p>Supplemental Materials and Methods</p>