A5054235872- Obstructive Sleep Apnea Research
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Neuroscience of respiration and sleep
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cancer, Lipids, and Metabolism
- Autophagy in Disease and Therapy
- Metastasis and carcinoma case studies
- Lymphatic System and Diseases
- 3D Printing in Biomedical Research
- Cancer Diagnosis and Treatment
- Cardiovascular and Diving-Related Complications
- Ovarian cancer diagnosis and treatment
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Sirtuins and Resveratrol in Medicine
- Polyomavirus and related diseases
- Viral-associated cancers and disorders
- interferon and immune responses
- Inflammatory Biomarkers in Disease Prognosis
- Lymphoma Diagnosis and Treatment
- RNA Research and Splicing
- Fatty Acid Research and Health
- Endoplasmic Reticulum Stress and Disease
Guizhou Provincial People's Hospital
2023-2025
Wenzhou Medical University
2024
Ruian People's Hospital
2024
Tianjin Medical University General Hospital
2018-2023
Lanzhou Petrochemical Polytechnic
2018
Abstract Background Emerging studies showed curcumin can inhibit glioblastoma and breast cancer cells via regulating ferroptosis. However, the role of ferroptosis in inhibitory effect on non‐small‐cell lung (NSCLC) remains unclear. Methods Cell counting kit‐8 (CCK‐8) assay was used to measure viability A549 H1299 under different conditions. proliferation examined by Ki67 immunofluorescence. The morphological changes tumor tissues were observed optical microscope hematoxylin eosin (H&E)...
Abstract Background Quercetin, a natural flavonoid compound, is potent cancer therapeutic agent widely found in fruit and vegetables. It has been reported to induce growth inhibition apoptosis both A549 H1299 human lung cells. However, the effect of quercetin‐induced autophagy on possible mechanism cells have not yet critically examined. Methods were treated with different concentrations quercetin for 24 hours. Cell was measured by cell counting kit‐8 (CCK‐8) assay, whereas assessed western...
Recently, increased tumor incidence and cancer-related mortality have been reported among patients with obstructive sleep apnea (OSA). Intermittent hypoxia (IH), the hallmark feature of OSA, contributes to metastasis tumors. However, molecular mechanisms by which is accelerated OSA-like IH remain be elucidated. C57BL/6 J male mice were subjected intravenous injection B16F10 melanoma cells before receiving treatment. Then, animals randomly distributed into three groups (n = 8 each): normoxia...
Background: Pulmonary lymphoepithelioma-like carcinoma (pLELC) is a rare subtype of non-small-cell lung cancer that predominantly affects younger, non-smoking individuals in southern and southeast Asia, where Epstein–Barr virus (EBV) prevalence high. The efficacy safety immunotherapy pLELC, especially second-line settings, remain inadequately explored. Objectives: This study aimed to evaluate the immunotherapy, either alone or combination with chemotherapy, improving progression-free...
Abstract Background Maintaining intestinal health is crucial for the overall well-being and productivity of livestock, as it impacts nutrient absorption, immune function, disease resistance. Oxidative stress inflammation are key threats to integrity. This study explored antioxidant, anti-inflammatory, barrier-strengthening properties a fermented plant macerate (FPM) derived from 45 local herbs, using specifically developed fermentation process utilizing plants’ inherent microbiota enhance...
Abstract Background m 6 A modification affects the pathological progress of many diseases by affecting RNA stability and translocation. YTHDC2, a reader, is associated with multiple cancers; however, little known its role in non‐small cell lung cancer (NSCLC). Methods The GEPIA, Oncomine GEO databases were analyzed to assess expression YTHDC2 NSCLC patients. Quantitative polymerase chain reaction, western blot immunohistochemistry used detect different lines (H1299, H460, H292 A549) effects...
RET rearrangements are rare, and occur in 1%-2% of all non-small cell lung cancer (NSCLC) patients. Pralsetinib has a significant anti-tumor effect patients with advanced NSCLC rearrangement. Previous studies have confirmed the efficiency neoadjuvant target therapy for NSCLC. Herein we present case involving female patient who was diagnosed stage IIIA adenocarcinoma harbored KIF5B-RET rearrangement based on next-generation sequencing. Radiologic downstaging indicated after pralsetinib...
Abstract Metastasis remains major cause of treatment failure in non-small cell lung cancer (NSCLC). A comprehensive characterization the transcriptomic landscape NSCLC-cells with organ-specific metastatic potentials would advance our understanding NSCLC metastasis process. In this study, we established bone-metastatic (BoM), brain-metastatic (BrM), and lymph-metastatic (LnM) cells by an vivo spontaneous model. Subsequently, analyzing entire profiles BoM, BrM, LnM, LuM, comparison their...
To investigate the protein expressions of steroid receptor coactivator amplified in breast cancer 1 (AIB1), apoptosis-related p53 and B-cell lymphoma-2 (Bcl-2) epithelial ovarian cancer; to analyze correlations among these three proteins; explore their with clinical pathological features prognosis.Immunohistochemistry streptavidin-peroxidase (IHC-SP) method was performed detect positive AIB1, Bcl-2, sections normal tissues, benign tumor, cancer, thereby analyzing expression rates genes...
Eliciting tumour microenvironment (TME) activation in triple-negative breast cancer (TNBC) is crucial for effective anti-tumour therapies. The aim of this study to employ pharmaceutical approaches precisely deliver Ganoderma polysaccharide (GPS) sites, thereby enhancing TME activation. We first established a direct link between the accumulation GPS within tumours and its efficacy Building upon insight, we then engineered mannose/hyaluronic acid dual-coated GPS-loaded superparamagnetic iron...
Cigarette smoke may play a direct role in proliferation of human pulmonary artery smooth muscle cells (HPASMCs). However, the mechanism involved and effect interventions remain unclear. We aimed to evaluate cigarette extract (CSE) on HPASMCs, explore inflammation oxidative stress, effects Tempol PDTC this process.HPASMCs were subjected normal control (NC), CSE, CSE+Tempol (CSE+T), CSE+PDTC (CSE+P) groups. Proliferation HPASMCs was measured by CCK-8 Western blot. TNF-α, IL-6, MDA, SOD levels...
Abstract The coexistence of chronic obstructive pulmonary disease (COPD) and sleep apnea (OSA) can cause multiple system damage, the main physiological mechanisms are continuous hypoxia intermittent (IH). Airway mucus hypersecretion is an important clinical feature COPD, which a progressive decline lung function, acute COPD aggravation, progression. purpose our study to determine influence mild OSA on airway hypersecretion. Clinical data epithelial samples 36 subjects were collected. average...
Abstract Background Numerous predictive formulas based on different ethnics have been developed to determine continuous positive airway pressure (CPAP) for patients with obstructive sleep apnea (OSA) without laboratory-based manual titrations. However, few studies focused OSA in China. Therefore, this study aimed develop a equation determining the optimal value of CPAP Methods 526 pure moderate severe attended titrations during overnight polysomnogram were spited into either formula...
Abstract Introduction: Pulmonary sarcomatoid carcinoma (PSC) is an extremely rare biphasic tumor characterized by a mixture of malignant epithelial and mesenchymal cells. Owing to the rarity, as well lack typical manifestations imaging signs, rate misdiagnosis high. Herein, we present case PSC misdiagnosed pleural mesothelioma in 59-year-old man. Patient concerns: A man presented with recurrent coughing, fever, chest pain. Diagnosis: Chest computed tomography showed 2 large dense masses...