A5100345386- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Curcumin's Biomedical Applications
- Nanoparticle-Based Drug Delivery
- Ferroptosis and cancer prognosis
- Hearing, Cochlea, Tinnitus, Genetics
- Hearing Loss and Rehabilitation
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiovascular and Diving-Related Complications
- Gout, Hyperuricemia, Uric Acid
- Respiratory Support and Mechanisms
- Sleep and Wakefulness Research
- Asthma and respiratory diseases
- Circular RNAs in diseases
- Vestibular and auditory disorders
- Prenatal Screening and Diagnostics
- Autophagy in Disease and Therapy
- Pluripotent Stem Cells Research
- Metastasis and carcinoma case studies
- Neonatal and fetal brain pathology
- Renal and related cancers
- Antibiotics Pharmacokinetics and Efficacy
- Noise Effects and Management
- Antibiotic Resistance in Bacteria
- Cancer, Lipids, and Metabolism
Tianjin Medical University General Hospital
2013-2024
Second Affiliated Hospital of Nanchang University
2023
Nanchang University
2023
Entasis Therapeutics (United States)
2020
Third Xiangya Hospital
2019
Central South University
2019
Tianjin Medical University
2019
Sichuan University
2012
Abstract Background Emerging studies showed curcumin can inhibit glioblastoma and breast cancer cells via regulating ferroptosis. However, the role of ferroptosis in inhibitory effect on non‐small‐cell lung (NSCLC) remains unclear. Methods Cell counting kit‐8 (CCK‐8) assay was used to measure viability A549 H1299 under different conditions. proliferation examined by Ki67 immunofluorescence. The morphological changes tumor tissues were observed optical microscope hematoxylin eosin (H&E)...
Multidrug resistant Gram-negative bacterial infections are an increasing public health threat due to rapidly rising resistance toward β-lactam antibiotics. The hydrolytic enzymes called β-lactamases responsible for a large proportion of the phenotype. β-Lactamase inhibitors (BLIs) can be administered in combination with antibiotics negate action β-lactamases, thereby restoring activity β-lactam. Newly developed BLIs offer some advantage over older terms enzymatic spectrum but limited...
Cigarette smoke (CS)-caused ferroptosis was involved in the pathogenesis of COPD, but role lung epithelial injury and inflammation is not clear. Rats were treated with CS or CUR BEAS-2B cells exposed to extract (CSE), ferrostatin-1 (Fer-1), deferoxamine (DFO), detect reactive oxygen species (ROS) accumulation, lipid peroxidation, iron overload, ferroptosis-related protein, which characteristic changes ferroptosis. Compared control group, CSE-treated had more cell death, higher cytotoxicity,...
The diagnosis and severity of obstructive sleep apnea (OSA) are commonly based on the hypopnea index (AHI). However, patients with similar AHIs may show widely varying comorbidities risks for cardiovascular disease, which be associated different severities nocturnal hypoxia. percentage cumulative time oxygen saturation below 90% in total (T90) is receiving increasing attention OSA research because it describes duration degree hypoxia during whole sleep. This study aimed to explore...
Curcumin has been proven to effectively inhibit tumor growth by both targeting cells and angiogenesis; however, poor water solubility limits further clinical application. In the present study, we prepared water-soluble liposomal curcumin investigate its anti-tumor effects underlying mechanism. The MTT assay was used test anti-proliferative activities for MS1 murine endothelial LL/2 Lewis lung cancer cell lines. Apoptosis cycle arrest induced were analysed flow cytometry. Anti-angiogenic...
As age-related diseases, chronic kidney disease and hearing impairment (HI) cause a serious socioeconomic burden. Due to structural similarities, there is certain connection between function hearing, but has been no large-scale epidemiological study in China that further explored this connection. Thus, aimed explore the association indicator levels of among middle-aged elderly individuals Tianjin, China.In 2020, 1539 participants aged 45 years or older from China, were recruited into study....
Little is known about the distribution of etiology in obstructive sleep apnea (OSA) combined with chronic breathlessness. A significant portion patients this group have so-called "overlap syndrome (OVS)", characterized by pulmonary disease (COPD). OVS has more complications and a poorer prognosis compared to either OSA or COPD alone, which makes it important identify early OSA. The current study was retrospective cross-sectional analysis consecutive adult who were diagnosed (n = 1062), whom...
Abstract The coexistence of chronic obstructive pulmonary disease (COPD) and sleep apnea (OSA) can cause multiple system damage, the main physiological mechanisms are continuous hypoxia intermittent (IH). Airway mucus hypersecretion is an important clinical feature COPD, which a progressive decline lung function, acute COPD aggravation, progression. purpose our study to determine influence mild OSA on airway hypersecretion. Clinical data epithelial samples 36 subjects were collected. average...
Abstract Background Numerous predictive formulas based on different ethnics have been developed to determine continuous positive airway pressure (CPAP) for patients with obstructive sleep apnea (OSA) without laboratory-based manual titrations. However, few studies focused OSA in China. Therefore, this study aimed develop a equation determining the optimal value of CPAP Methods 526 pure moderate severe attended titrations during overnight polysomnogram were spited into either formula...
Purpose: Obstructive sleep apnea (OSA) plays an important role in the pathogenesis of hypertension. The aim this cross-sectional study was to explore clinical and polysomnographic characteristics OSA patients with hypertension gender differences relationship between rapid eye movement (REM) Patients Methods: A total 808 at a tertiary hospital were enrolled study, divided into groups presenting or without compared groups. Multivariate binary logistic analysis performed assess association REM...
Hearing loss is a modifiable risk factor for dementia and cognitive decline. However, the association between cognition hearing acuity at different frequencies unknown. We aimed to assess relationships with global function five domains of among low-income elderly population in northern rural China. A population-based cross-sectional study was conducted collect basic information from residents aged 60 years older areas Tianjin, China April 2012 November 2013. Pure tone averages (PTAs) ear...
Abstract Background Obstructive sleep apnea (OSA) is currently recognized as a risk factor for dysmetabolism. However, the effect of OSA on serum uric acid (SUA) levels in patients with obesity remains unclear. This study aimed to investigate association between SUA and determine whether bariatric surgery (laparoscopic sleeve gastrectomy (LSG)) could decrease levels. Methods A total 182 were recruited this study. All patients' demographic data, polysomnography (PSG), SUA, blood glucose,...
Abstract Introduction: Pulmonary sarcomatoid carcinoma (PSC) is an extremely rare biphasic tumor characterized by a mixture of malignant epithelial and mesenchymal cells. Owing to the rarity, as well lack typical manifestations imaging signs, rate misdiagnosis high. Herein, we present case PSC misdiagnosed pleural mesothelioma in 59-year-old man. Patient concerns: A man presented with recurrent coughing, fever, chest pain. Diagnosis: Chest computed tomography showed 2 large dense masses...