A5100364243- Myasthenia Gravis and Thymoma
- Pituitary Gland Disorders and Treatments
- Meningioma and schwannoma management
- Sarcoma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Peripheral Neuropathies and Disorders
- Protein Tyrosine Phosphatases
- RNA modifications and cancer
- Galectins and Cancer Biology
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Traumatic Brain Injury and Neurovascular Disturbances
- Vascular Tumors and Angiosarcomas
- Ubiquitin and proteasome pathways
- Cancer-related Molecular Pathways
- Thyroid and Parathyroid Surgery
- Diabetes and associated disorders
- Cardiac, Anesthesia and Surgical Outcomes
- RNA Interference and Gene Delivery
- Silk-based biomaterials and applications
- Lung Cancer Treatments and Mutations
- Wnt/β-catenin signaling in development and cancer
- Intracerebral and Subarachnoid Hemorrhage Research
Jining First People's Hospital
2025
Southern Medical University
2009-2025
Northeast Agricultural University
2017-2025
Zhujiang Hospital
2009-2025
First Hospital of Jilin University
2020-2025
Jilin University
2020-2025
Tianjin Medical University General Hospital
2015-2024
Henan Cancer Hospital
2014-2024
Zhengzhou University
2014-2024
Soochow University
2010-2024
The mechanisms underlying hypermethylation of tumor-suppressor gene promoters in cancer is not well understood. Here, we report that lysine acetylation the oncogenic transcription factor STAT3 elevated tumors. We also show genetically altering at Lys685 reduces tumor growth, which accompanied by demethylation and reactivation several genes. Moreover, mutating disrupts DNA methyltransferase 1–STAT3 interactions cultured cells These observations are confirmed treatment with an inhibitor,...
Rationale: Aortic aneurysm is a life-threatening cardiovascular disorder caused by the predisposition for dissection and rupture. Genetic studies have proved involvement of transforming growth factor-β (TGF-β) pathway in aortic aneurysm. Smad4 central mediator canonical TGF-β signaling pathway. However, exact role smooth muscle cells (SMCs) leading to pathogenesis aneurysms largely unknown. Objective: To determine aneurysms. Methods Results: Conditional gene knockout strategy combined with...
Toll-like receptor (TLR) signaling is critical in innate response against invading pathogens. However, the molecular mechanisms for full activation of TLR-triggered immunity need to be fully elucidated. The broad complex tramtrack bric-a-brac/poxvirus and zinc finger (BTB/POZ) family a class transcription factors involved many biological processes. few BTB/POZ proteins were reported function immune response. Zinc BTB domain-containing 20 (ZBTB20), member family, functions neurogenesis...
Abstract Gene fusions and their chimeric products are common features of neoplasia. Given that many cancers arise by the dysregulated recapitulation processes in normal development, we hypothesized comparable gene may exist cells. Here, show a RNA, PAX3–FOXO1, identical to found alveolar rhabdomyosarcoma, is transiently present cells undergoing differentiation from pluripotent into skeletal muscle. Unlike these do not seem harbor t(2;13) chromosomal translocation. Importantly, both...
Abstract Receptor protein tyrosine phosphatase sigma (RPTPσ) regulates neuronal extension and acts as a presynaptic nexus for multiple proteoglycan interactions during synaptogenesis. Unknown mechanisms govern the shift in RPTPσ function, from outgrowth promotion to synaptic organization. Here, we report crystallographic, electron microscopic small-angle X-ray scattering analyses, which reveal sufficient inter-domain flexibility extracellular region interaction with both cis (same cell)...
Increasing studies have shown that specific mRNAs and miRNAs expressed in mature sperm may be related to motility. However, the expression profiles roles of lncRNAs remain unknown. In present study, numerous were identified human sperm, some exclusively testis. Compared with those normal lncRNA asthenozoospermia (AZS) showed significant differences. Gene ontology pathway analyses function differentially targets between AZS closely linked many processes involved spermatogenesis function....
Introduction: Chronic osteomyelitis remains a clinical challenge in orthopedics. Methods: In this study, silk fibroin microspheres (SFMPs) loaded with vancomycin are entrapped an injectable hydrogel to form delivery system for treatment of chronic osteomyelitis. Results and Discussion: Vancomycin showed continuous release from the up 25 days. The shows strong antibacterial activity against both Escherichia coli Staphylococcus aureus long duration 10 days without decrease effect. injection...
Abstract Hematological malignancies (HM) like acute myeloid leukemia (AML) are often intractable. Cancer vaccines possibly inducing robust and broad anti‐tumor immune responses may be a promising treatment option for HM. Few effective against blood cancers are, however, developed to date partly owing insufficient stimulation of dendritic cells (DCs) in the body lacking appropriate tumor antigens (Ags). Here it is found that systemic multifunctional nanovaccines consisting nucleotide‐binding...
The co-delivery of DNA and antitumor drugs has the potential to treat cancer. In this study, we aimed develop surface-modified, co-encapsulated solid lipid nanoparticles (SLN) containing enhanced green fluorescence protein plasmid (pEGFP) doxorubicin (DOX) in order create a multifunctional delivery system that targets lung cancer cells, an effort improve efficacy therapy. DOX- pEGFP-loaded SLN were prepared separately then mixed form (SLN/DE). Transferrin (Tf)-containing ligands used for...
Cell penetrating peptides (CPPs) are commonly utilized for intracellular delivery of functional materials to circumvent biomembrane barrier.However, further application CPPs is hindered by lacking selectivity toward targeted cells.The spider venom peptide, lycosin-I, a CPP with potent cytotoxicity cancer cells, which might enable lycosin-I deliver into cells selectively.In this study, we demonstrated that the lycosin-I-conjugated spherical gold nanoparticles (LGNPs) not only exhibited...
Accumulating evidence reveals the principal role of long noncoding RNAs in progression clear cell renal carcinoma (ccRCC).However, little is known about underlying mechanism ADAM metallopeptidase with thrombospondin type 1 motif, 9 antisense RNA 2 (ADAMTS9-AS2) ccRCC.Here, bioinformatics analyses verified ADAMTS9-AS2 a and its high expression was associated better prognosis ccRCC.ADAMTS9-AS2 clearly downregulated ccRCC clinical samples lines.Clinical data showed lowexpressed correlated worse...
Abstract Acute myeloid leukemia (AML) is the most refractory hematologic malignancy characterized by acute onset, rapid progression, and high recurrence rate. Here, codelivery of BCL2 (ABT199) MCL1 (TW37) inhibitors using phenylboronic acid‐functionalized polypeptide nanovehicles to achieve synergetic potent treatment AML adopted. Leveraging dynamic boronic ester bonds, BN coordination, π – stacking, reveal remarkably efficient robust drug coencapsulation. ABT199 can induce a series...
Transplantation of olfactory ensheathing cells (OECs) is a potential treatment for spinal cord injury (SCI). However, this process lacks extracellular matrix guiding cell growth, tissue morphogenesis, and remodeling. In order to solve problem, we fabricated silk fibroin scaffolds (SFS) with different fiber diameters by electrospinning. The behaviors OECs on 300 1800 nm SFS were studied analyzing morphological feature, distribution, proliferation. results showed the good guide growth....
To evaluate the surgical outcomes of tumor resection with or without total thymectomy for thymic epithelial tumors (TETs) using Chinese Alliance Research in Thymomas (ChART) retrospective database.Patients preoperative therapy, who underwent surgery early-stage (Masaoka-Koga stage I and II) tumors, were enrolled study. They divided into thymomectomy groups according to extent thymus. Demographic compared between two patients groups.A 1,047 enrolled, 796 cases group 251 group. Improvement...