A5015930463- Ferroptosis and cancer prognosis
- Renal cell carcinoma treatment
- Chronic Lymphocytic Leukemia Research
- Advanced Fiber Laser Technologies
- Photorefractive and Nonlinear Optics
- RNA modifications and cancer
- Nanoplatforms for cancer theranostics
- Cancer-related molecular mechanisms research
- Cancer-related Molecular Pathways
- MicroRNA in disease regulation
- Cancer, Lipids, and Metabolism
- Peptidase Inhibition and Analysis
- Hepatitis B Virus Studies
- Multiple Myeloma Research and Treatments
- Circular RNAs in diseases
- Chemotherapy-induced cardiotoxicity and mitigation
- Acute Lymphoblastic Leukemia research
- Nonlinear Optical Materials Research
- Cell death mechanisms and regulation
- Solid State Laser Technologies
- Histone Deacetylase Inhibitors Research
- Extracellular vesicles in disease
- Lymphoma Diagnosis and Treatment
- Optical Network Technologies
- Developmental Biology and Gene Regulation
Zhuhai People's Hospital
2019-2023
Jinan University
2020-2023
Dalian University of Technology
2023
Harbin Medical University
2017-2022
Second Affiliated Hospital of Harbin Medical University
2022
First Affiliated Hospital of Harbin Medical University
2017-2019
The Ohio State University
2010-2017
University of Cincinnati
2006-2010
Cincinnati Children's Hospital Medical Center
2008-2010
Second Military Medical University
2000
Rationale: Hepatocellular carcinoma (HCC) is one of the leading causes mortality worldwide. Methyltransferase-like 3 (Mettl3), an RNA N6-methyladenosine (m6A) methyltransferase, has been shown to act as oncogene in several human cancers. However, regulatory role posttranslational modifications Mettl3 liver cancer remains elusive. Methods: SUMOylation was analyzed using immunoprecipitation and western blot assays. In vitro vivo biological functions were examined MTS, colony formation, wound...
Abstract Clear cell renal carcinoma (ccRCC) is a common genitourinary malignancy with high mortality. However, the molecular pathogenesis of ccRCC remains unclear and effective biomarkers for daily practice are still limited. Thus, we aimed to identify potential crucial genes pathways associated carcinogenesis further analyze mechanisms implicated in tumorigenesis. In present study, expression profiles GSE 66270, 53757, 36895, 76351 were downloaded from GEO database, including 244 matched...
Accumulating evidence reveals the principal role of long noncoding RNAs in progression clear cell renal carcinoma (ccRCC).However, little is known about underlying mechanism ADAM metallopeptidase with thrombospondin type 1 motif, 9 antisense RNA 2 (ADAMTS9-AS2) ccRCC.Here, bioinformatics analyses verified ADAMTS9-AS2 a and its high expression was associated better prognosis ccRCC.ADAMTS9-AS2 clearly downregulated ccRCC clinical samples lines.Clinical data showed lowexpressed correlated worse...
Histone deacetylase inhibitors (HDACi) have proven activity in hematologic malignancies, and their FDA approval multiple myeloma (MM) T-cell lymphoma highlights the need for further development of this drug class. We investigated AR-42, an oral pan-HDACi, a first-in-man phase 1 dose escalation clinical trial. Overall, treatment was well tolerated, no DLTs were evident, MTD defined as 40 mg dosed three times weekly weeks 28-day cycle. One patient each with MM mantle cell demonstrated disease...
<b><i>Article abstract</i></b> A population-based analysis of progressive multifocal leukoencephalopathy (PML) showed PML frequencies 5.1% among patients with AIDS and 0.07% hematologic malignancies, but similar clinical features in both groups. Sequencing the p53 gene, exon 4, heterozygosity (Arg-Pro) at codon 72 five six patients. These findings indicate that non–AIDS- AIDS-related differ markedly polymorphisms may influence occurrence
Background A pharmacokinetically derived schedule of flavopiridol administered as a 30 min intravenous bolus followed by 4-hour continuous infusion (IVB/CIVI) is active in fludarabine-refractory chronic lymphocytic leukemia, but no studies examining the feasibility and maximum tolerated dose this have been reported acute leukemia.Design Methods We conducted phase I escalation trial single-agent adults with relapsed/refractory leukemias, utilizing modification bolus/continuous approach,...
Background Flavopiridol is a cyclin-dependent kinase inhibitor in phase II clinical development for treatment of various forms cancer. When administered with pharmacokinetically (PK)-directed dosing schedule, flavopiridol exhibited striking activity patients refractory chronic lymphocytic leukemia. This study aimed to evaluate pharmacogenetic factors associated inter-individual variability pharmacokinetics and outcomes therapy. Methodology/Principal Findings Thirty-five who received...
Increasing evidence indicates that the dysregulation of circular RNAs (circRNAs) plays important roles in tumor progressions.In this study, we first analyzed circ-FOXO3 level bladder cancers (BCs), and then BC cell lines were transfected with expression vector, proliferation, migration, invasion abilities analyzed. We also used bioinformatics tools to predict potential-binding miRNAs for circ-FOXO3, luciferase reporter assay was verification binding miRNAs. For further potential...
The most common type of kidney tumor, clear-cell renal cell carcinoma (ccRCC) with relatively insidious development and easily metastatic characteristics is generally insensitive to cytotoxic chemotherapy. abundant polyunsaturated fatty acids (PUFAs) content in advanced ccRCC allows it be intrinsically vulnerable ferroptosis-based therapeutic strategies. Nevertheless, the strategy cause "iron overload" by administration iron-based nanomaterials has limited efficacy. And classic ferroptosis...
Keratinocyte is the predominant cell type in epidermis of skin, and it provides protective barrier function for body.Various signaling pathways have been implicated keratinocyte differentiation animal models; However, their temporal regulation interactions are still to be explored pluripotent stem models.In this report, we use human embryonic cells demonstrate that epidermal ectoderm subsequent fate can determined step by under defined factors.The inhibition TGFβ initiates ectodermal lineage...
Background . The role of HERV–H LTR‐associating 2 (HHLA2) in cancer remains still unclear. This study analyzed the correlation between prognosis and immune infiltrate function HHLA2 pan‐cancers. Methods expression pan‐cancers was using databases TCGA, GTEx, TIMER, GEPIA, UALCAN, GSEA databases. Multiple bioinformatic methods were used to investigate with survival, pathological stage, tumor mutation burden (TMB), microsatellite instability (MSI), microenvironment (TME), cell infiltration,...
The composition of kidney stones is related to the hardness stones. Knowing before surgery can help plan laser power and operation time percutaneous nephroscopic surgery. Moreover, patients be treated with medications if stone compounded by uric acid treatment, which relieve pain However, although literature generally reports analysis method base on dual-energy CT images, accuracy these methods not enough; they need manual delineation location, cannot analyze mixed stones.This study aimed...
Abstract: Renal cell carcinoma (RCC) is a common type of kidney cancer. Normally, surgical treatment can prolong life, but only for patients with early stage tumors. However, it difficult detection strategies to distinguish between benign and malignant Therefore, potential biomarkers diagnosis prognosis RCC are needed. Intriguingly, mounting evidence has demonstrated that many long noncoding RNAs (lncRNAs) strongly linked cancers. Indeed, promising RCC-associated lncRNA have also been...
Multimodality imaging can reveal complementary anatomic and functional information as they exploit different contrast mechanisms, which has broad clinical applications promises to improve the accuracy of tumor diagnosis. Accordingly, attain particular goal, it is critical multimodal agents. In present work, we develop novel cobalt core/carbon shell–based nanoparticles (Cobalt at carbon NPs) with both magnetization light absorption properties for dual-modality magnetic resonance (MRI)...
Riesen, S. C., Ni, W., Carnes, C. A., Lindsey, K. J., Phelps, M. Schober, E. Pharmacokinetics of oral ivabradine in healthy cats. J. vet. Pharmacol. Therap. 34 , 469–475. A liquid chromatography‐tandem mass spectrometry (LC‐MS/MS) analytical method for the measurement novel heart rate–lowering drug and its major metabolite, S‐18982, was cross‐validated plasma eight Plasma concentrations were then determined after single repeated administration ivabradine. Individual versus time from each cat...
With the increasing coexistence of cardiovascular disease and cancer in contemporary clinical practice, studies on outcomes acute myocardial infarction (AMI) patients with has not been systematically investigated. This study sought to investigated effect coexisting treatment among AMI patients.We retrospectively integrated analyzed data 6,607 between June 2016 December 2019. Patients were compared pair-matched cancer-naive patients. Cox proportional hazards models constructed compare...
Photosensitizers have emerged as cytotoxic reactive oxygen species (ROS) activators in photodynamic therapy (PDT), which induced cell apoptosis. As the major contributors to ROS and oxidative stress, mitochondria play an important role Although there are many reports about near-infrared 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) photosensitizers (PSs) for PDT, this kind of PS has rarely been used treating mitochondrial function choroidal neovascularization application at same time....
Ciliary neurotrophic factor (CNTF) acts through the JAK/STAT signal transduction pathway. However, rapid action of CNTF cannot readily be explained by reference to this Using fluorophore, Fura 2-AM, and fluorescence imaging, effect on glutamate-induced increases in hippocampal intraneuronal free Ca2+ ([Ca2+]i) was investigated. Glutamate induces a increase [Ca2+]i. Incubation neurons with for 5 min inhibited In absence glutamate, had no Pertussis toxin (PTX), G-protein antagonist, partially...