A5101280145- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Cerebrovascular and Carotid Artery Diseases
- Genomics and Rare Diseases
- Antiplatelet Therapy and Cardiovascular Diseases
- Metabolism and Genetic Disorders
- Infective Endocarditis Diagnosis and Management
- Advanced MRI Techniques and Applications
- Iron Metabolism and Disorders
- Inflammatory Biomarkers in Disease Prognosis
- Dialysis and Renal Disease Management
- Breastfeeding Practices and Influences
- Cardiovascular Function and Risk Factors
- Epigenetics and DNA Methylation
- Cardiac Valve Diseases and Treatments
- Cancer, Hypoxia, and Metabolism
- Hormonal Regulation and Hypertension
- Erythropoietin and Anemia Treatment
- Folate and B Vitamins Research
- Lipoproteins and Cardiovascular Health
- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiac Structural Anomalies and Repair
- Acute Myocardial Infarction Research
- Biochemical and Molecular Research
- Renal cell carcinoma treatment
Sixth Affiliated Hospital of Sun Yat-sen University
2024-2025
Sun Yat-sen University
2024-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2024
China-Japan Friendship Hospital
2023-2024
Peking Union Medical College Hospital
2024
Harbin Medical University
2019-2023
Second Affiliated Hospital of Harbin Medical University
2020-2023
Heilongjiang Provincial Hospital
2016-2019
This study seeks to elucidate the clinical and biochemical features of Ornithine transcarbamylase deficiency (OTCD), a pleomorphic congenital hyperammonemia disorder with non-specific phenotype. Additionally, research aims analyze mutation spectrum OTC gene its potential association phenotype, as well perform an in silico analysis novel variants their structure-function relationship. In this study, we conducted retrospective 12 patients OTCD examined metabolite profiles. reviewed existing...
Objective This study compares the cardiovascular risk in anemic chronic kidney disease patients treated with Roxadustat versus erythropoietin stimulating agents (ESAs). It also explores impact of Roxadustat. Methods We searched PubMed, EMBASE, Cochrane, Scopus, and Web Science databases up to 13 August 2023, using terms such as “ESA,” “Roxadustat,” “MACE,” “stroke,” “death,” “myocardial infarction,” “heart failure.” Two researchers independently selected extracted data based on predefined...
Blood glucose levels significantly affect the clinical prognosis of patients with coronary artery disease (CAD), and systemic immune inflammation is a common risk factor for both CAD diabetes. However, relationship between poor in different metabolic statuses remains unclear.Between January 2007 December 2020, we recruited 84,645 CAD. The index (SII) was used to comprehensively reflect inflammatory calculated using following formula: neutrophils × platelets/lymphocytes. were classified into...
Diabetic kidney disease (DKD) is the leading cause of chronic worldwide and strongest predictor mortality in patients with diabetes. Despite its significance, pathological mechanism underlying onset progression DKD remains incompletely understood. In this study, we have shown that mitochondrial ribosomal protein L12 (MRPL12) plays a significant role by modulating function. We demonstrated MRPL12 was mainly ubiquitinated at K150 renal tubular epithelial cells. found Cullin3 (CUL3), an E3...
In-stent restenosis (ISR) still exists after drug-eluting stent (DES) implantation, even up to one year. The incidence and risk factors for neoatherosclerosis in patients with early ISR have not yet been elucidated. Here, we used optical coherence tomography (OCT) evaluate the predictors of ISRs.OCT was performed on lesions 185 order detect neoatherosclerosis. median follow-up 180 days, detected 37% lesions. According presence neoatherosclerosis, were divided into two groups: (group A, n =...
Aims This study aimed to investigate the progression and vascular shrinkage of vulnerable plaque lesions with a burden at least 70% among patients coronary artery disease by optical coherence tomography (OCT) intravascular ultrasound (IVUS). Methods Fifty-six OCT-identified plaques from 47 were included angiography-identified nonculprit/nontarget lesions. Serial IVUS images used assess shrinkage. Results Thirty-five small (plaque <70%, group A) 21 large ≥70%, B) identified. The results...
// Zulong Xie 1,2,* , Nana Dong 1,3,* Rong Sun 1,3 Xinxin Liu Xia Gu 4 Yong Hongwei Du Jiannan Dai Youbin Jingbo Hou Jinwei Tian and Bo Yu 1 Department of Cardiology, The Second Affiliated Hospital Harbin Medical University, Harbin, China 2 Chongqing Chongqing, 3 Key Laboratory Myocardial Ischemia, Chinese Ministry Education, Heilongjiang Provincial Hospital, * These authors have contributed equally to this work Correspondence to: Tian, email: Yu, Keywords : atherosclerosis; plaque...
To accurately verify the pathogenicity of variants uncertain significance (VUS) in
Background Citrullinemia type I disorders (CTLN1) is a genetic metabolic disease caused by argininosuccinate synthetase (ASS1) gene mutation. To date, the human genome mutation database has documented over 100 variants of ASS1 gene. This study reported novel deletion-insertion variant and employed various prediction tools to determine its pathogenicity. Methods We case early-onset CTLN1. Whole exome sequencing was conducted identify mutations. structure generate accurate 3D models utilized...
Bile acids are closely associated with necrotizing enterocolitis (NEC), and their accumulation has cytotoxic effects on cells. However, the specific bile acid subtype involved in NEC its underlying mechanisms remains poorly understood, limiting therapeutic potential of as treatment targets. In present study, deoxycholic (DCA) intestinal lumen exacerbated NEC-induced damage. DCA suppressed expression mesenchymal-epithelial transition factor (MET), a proto-oncogene located chromosome 7q31.2...
Background: Dilated cardiomyopathy (DCM) has a poor prognosis and high mortality. The relationship between the deformation capacity of biatrial biventricular regions in patients with DCM remains unclear. Methods: This retrospective study used cardiovascular magnetic resonance (CMR) to assess patient enrollment September 2020 May 2022. Feature tracking (FT) was evaluate global radial strain (GRS), circumferential (GCS) longitudinal (GLS). Fast long-axis method GLS by analyzing balanced...
Congenital heart diseases can be treated without surgery through advances in interventional cardiology. Complications such as infection and thrombus formation may develop due to foreign materials used during these procedures. Paradoxical embolism is a rare complication of transcatheter closure ventricular septal defect (VSD) could responsible for acute myocardial infarction. Herein, we present case coronary thrombosis 2-year-old patient with VSD, which was closed the Amplatzer VSD device....