A5100325915- Gut microbiota and health
- Infant Nutrition and Health
- IL-33, ST2, and ILC Pathways
- Trace Elements in Health
- Iron Metabolism and Disorders
- Neonatal Respiratory Health Research
- Ginseng Biological Effects and Applications
- Heavy Metal Exposure and Toxicity
- Clostridium difficile and Clostridium perfringens research
- Probiotics and Fermented Foods
- Diet and metabolism studies
- Traditional Chinese Medicine Studies
- Child Nutrition and Feeding Issues
- Clinical Nutrition and Gastroenterology
- Colorectal Cancer Screening and Detection
- Anesthesia and Neurotoxicity Research
- Animal Nutrition and Physiology
- Curcumin's Biomedical Applications
- Antioxidant Activity and Oxidative Stress
- Tryptophan and brain disorders
- Autism Spectrum Disorder Research
- Pharmacological Effects of Natural Compounds
- Breastfeeding Practices and Influences
- Phosphodiesterase function and regulation
- Oral microbiology and periodontitis research
Sixth Affiliated Hospital of Sun Yat-sen University
2013-2024
Sun Yat-sen University
2013-2024
Yangzhou University
2022-2024
China Pharmaceutical University
2019-2024
BGI Group (China)
2023
First Affiliated Hospital of Nanchang University
2023
Nanchang University
2018-2023
Guangdong Provincial People's Hospital
2023
XinHua Hospital
2019-2022
Shanghai Jiao Tong University
2021-2022
Background: Bacterial constituents, such as Gram‐negative derived lipopolysaccharide (LPS), can initiate inflammatory bone loss through induction of host‐derived cytokines. The aim this study was to establish a model aggressive alveolar in rats using LPS from the periodontal pathogen Actinobacillus actinomycetemcomitans . Methods: Eighteen female Sprague‐Dawley were divided into test (N = 12) and saline control 6) groups. All animals received injections palatal molar gingiva three times per...
Glucosinolates, phytochemicals found in cruciferous vegetables, are metabolised to bioactive isothiocyanates (ITC) by certain bacteria the human gut. Substantial individual variation urinary ITC excretion has been observed previous vegetable-feeding studies. We hypothesised that differences gut microbial community contribute glucosinolate metabolism, i.e. microbiota composition between high- and low-ITC excreters differs. recruited twenty-three healthy individuals fed them a standardised...
Lignans in plant foods are metabolized by gut bacteria to the enterolignans, enterodiol (END) and enterolactone (ENL). Enterolignans have biologic activities important prevention of cancer chronic diseases. We examined composition microbial community (GMC) as a contributor human enterolignan exposure.
Ulcerative colitis is closely associated with the dysregulation of gut microbiota. There growing evidence that natural products may improve ulcerative by regulating In this research, we demonstrated bergenin, a naturally occurring isocoumarin, significantly ameliorates symptoms in dextran sulfate sodium (DSS)-induced mice. Transcriptomic analysis and Caco-2 cell assays revealed bergenin could ameliorate inhibiting TLR4 NF-κB mTOR phosphorylation. 16S rRNA sequencing metabolomics analyses...
Abstract Objective To reveal whether gut microbiota and their metabolites are correlated with oocyte quality decline caused by circadian rhythm disruption, to search possible approaches for improving quality. Design A mouse model exposed continuous light was established. The quality, embryonic development, microbial were analyzed. Intragastric administration of conducted confirm the relationship between development. Results Firstly, we found that development decreased in mice light. Through...
BackgroundIncreased frequency of CCR9+ CD4+ T cells in peripheral blood is linked to several gastrointestinal inflammatory diseases; however, its relationship with necrotizing enterocolitis (NEC) not understood. We investigated whether the frequencies and related subsets were increased both patients mice NEC.MethodsCCR9+ evaluated by flow cytometry collected from NEC controls. The suppressive function regulatory (Treg) was assessed via vitro suppression assay. An cell polarization assay...
Background: Gram‐negative bacterial species, such as Actinobacillus actinomycetemcomitans , contain lipopolysaccharide (LPS) that initiates the innate immune system, resulting in inflammatory alveolar bone loss. LPS activates Toll‐like receptors on membrane surfaces, stimulating many intracellular signaling cascades, including p38 mitogen‐activated protein kinase (MAPK). Activation of mediates cytokine expression, contributing toward osteoclastogenesis and The aim this study was to determine...
Fibre has been shown to exert a number of benefits on gastrointestinal (GI) health, yet its intake is low. Addition novel fibres food products may increase fibre and improve gut health. The objective the present study was evaluate influence three GI outcomes in healthy human subjects. A total twenty participants (ten men ten women) with normal BMI (23 ( sem 2) kg/m 2 ) participated randomised, double-blind, cross-over five treatment periods. Participants consumed maltodextrin control or...
Hyperlipidemia is a major component of metabolic syndrome, and regarded as one the main risk factors causing diseases. We have developed therapeutic drug, akebia saponin D (ASD), determined its anti-hyperlipidemia activity potential mechanism(s) action by analyzing metabolome intestinal microbiota. Male Sprague-Dawley rats were fed high fat diet to induce hyperlipidemia, then given ASD orally for 8 weeks. Lipid levels in serum biochemically. Metabolites serum, urine feces analyzed...
Abstract Microbiome dysfunction is considered to contribute the pathogenesis of many neurodegenerative diseases. However, relationship between gut microbiome and glaucoma, a disorder remains largely unknown. Here, we identified that glaucoma patients were rich in Dysgonamonadaceae, along with lower level Barnesiellaceae by metagenomic sequencing. This pattern shown increased production short chain fatty acids (SCFAs) fecal blood samples. Reducing these glaucoma‐specific bacteria...
Different infant diets have strong effects on child development and may engender variations in fecal microbiota metabolites.
Bile acids (BAs) have increasingly been implicated in the onset and progression of necrotizing enterocolitis (NEC); multiple findings demonstrated their ability to induce damage intestinal epithelium, thereby exacerbating disease severity. Although we previously showed that melatonin was able treat NEC by correcting Treg/Th17 imbalance, modulatory effect on BAs remains unclear. In this study, conducted transcriptome analysis tissues from patients with validated these findings. Subsequently,...
Lactoferrin (LF) has been shown to be effective in attenuating some aging-related changes, although its potential alleviating cognitive decline remains clarified. In this study, we evaluated the effects of LF (2000 mg/kg/day for 3 months) on ability 16-month-old C57/BL6J mice. Spatial cognition was improved aged mice after administration, with more pyramidal cells detected hippocampi, and regular distribution. also reduced iron deposition, malondialdehyde (MDA) ROS levels hippocampus....
Background and Objective: Autism spectrum disorder (ASD) refers to a heterogeneous set of neurodevelopmental disorders with diverse symptom severity comorbidities. Although alterations in gut microbiota have been reported individuals ASD, it remains unclear whether certain microbial pattern is linked specific or comorbidity ASD. We aimed investigate the associations between social impairment cognitive functioning children Methods: A total 261 age-matched children, including 138 diagnosed 63...
Necrotizing enterocolitis (NEC) is a catastrophic gastrointestinal emergency in preterm infants, whose exact aetiology remains unknown. The role of lithocholic acid (LCA), key component secondary bile acids (BAs), NEC unclear.Clinical data were collected to analyse the changes BAs patients. In vitro studies, cell proliferation and death assessed. vivo experiments, newborn rats administered with low or high dose LCA further induced NEC.Clinically, compared control group, total patients...