A5100319986- Cerebrovascular and genetic disorders
- Coral and Marine Ecosystems Studies
- Gut microbiota and health
- Cancer-related gene regulation
- Genetics, Bioinformatics, and Biomedical Research
- Cancer Cells and Metastasis
- Mycobacterium research and diagnosis
- Cancer-related molecular mechanisms research
- Marine and coastal plant biology
- Parasite Biology and Host Interactions
- Marine and fisheries research
- SARS-CoV-2 and COVID-19 Research
- Ocean Acidification Effects and Responses
- CRISPR and Genetic Engineering
- Gene expression and cancer classification
- Aquaculture disease management and microbiota
- Diet and metabolism studies
- Probiotics and Fermented Foods
- PARP inhibition in cancer therapy
- Marine Bivalve and Aquaculture Studies
- MicroRNA in disease regulation
- Biomedical Text Mining and Ontologies
- Health Systems, Economic Evaluations, Quality of Life
- Epigenetics and DNA Methylation
- Transplantation: Methods and Outcomes
Chinese Academy of Sciences
2012-2024
South China Sea Institute Of Oceanology
2012-2024
Institute of Oceanology
2012-2024
Institute of Deep-Sea Science and Engineering
2024
University of Hong Kong
2024
Zhejiang Wanli University
2022-2024
Indiana University – Purdue University Indianapolis
2018-2024
Indiana University School of Medicine
2018-2024
First Affiliated Hospital of Anhui Medical University
2012-2024
Anhui Medical University
2012-2024
Little is known about the transcriptomic plasticity and adaptive mechanisms of circulating tumor cells (CTCs) during hematogeneous dissemination. Here we interrogate transcriptome 113 single CTCs from 4 different vascular sites, including hepatic vein (HV), peripheral artery (PA), (PV) portal (PoV) using single-cell full-length RNA sequencing in hepatocellular carcinoma (HCC) patients. We reveal that transcriptional dynamics were associated with stress response, cell cycle immune-evasion...
Abstract Chiral polyfluoroarene derivatives are an important scaffold in chemistry. An unprecedented enantioselective C−H alkylation of polyfluoroarenes with alkenes is described. The reaction employs bulky chiral N‐heterocyclic carbene (NHC) ligands for nickel catalysts to enable exclusive activation bonds over C−F and complete endo ‐selective annulation excellent enantioselectivity. A wide variety fluorotetralins, compounds otherwise difficultly accessed but serve as bioisosteric analogs...
Significance Retinopathy is the leading cause of blindness, and development effective therapy urgently needed. Here, we defined an unprecedented subgroup microglia that responsible for causing retinopathy under hypoxia. Mechanistic studies demonstrated signaling pathway hypoxia-induced necroptosis retinal microglia, i.e., hypoxia–RIP1–RIP3–MLKL axis, triggered explosive release FGF2, which in its turn to induce neovascularization. Simultaneous targeting necroptosis–FGF2 VEGF produces...
SARS-CoV-2, the causative agent for COVID-19, infect human mainly via respiratory tract, which is heavily inhabited by local microbiota. However, interaction between SARS-CoV-2 and nasopharyngeal microbiota, association with metabolome has not been well characterized. Here, metabolomic analysis of blood, urine, swabs from a group COVID-19 non-COVID-19 patients, metagenomic pharyngeal samples were used to identify key features COVID-19. Results showed lactic acid, l-proline, chlorogenic acid...
Lipid droplets (LDs) are cellular organelles critical for lipid homeostasis, with intramyocyte LD accumulation implicated in metabolic disorder-associated heart diseases. Here we identify a human long non-coding RNA, Lipid-Droplet Transporter (LIPTER), essential transport cardiomyocytes. LIPTER binds phosphatidic acid and phosphatidylinositol 4-phosphate on surface membranes the MYH10 protein, connecting LDs to MYH10-ACTIN cytoskeleton facilitating transport. deficiencies impair trafficking,...
Intestinal microbiota is closely associated with various metabolic diseases such as type 2 diabetes (T2D), and definitely affected by diet. However, more work required to gain detailed information about gut metagenome their impact diet in T2D patients. We used a streptozotocin-high-fat (HFD) induce mouse model investigated the effect of standard chow HFD on composition function microbiota. found that could worsen status compared 16S rRNA gene sequencing revealed caused large disturbance...
The gut microbiota is associated with cardiovascular diseases, including atherosclerosis. However, the composition, functional capacity, and metabolites of microbiome about atherosclerosis have not been comprehensively studied. Here, we reanalyzed 25 metagenomic stool samples from Sweden 385 China using HUMAnN2, PanPhlAn, MelonnPan to obtain more sufficient information. We found that atherosclerotic patients in both cohorts were depleted Bacteroides xylanisolvens, Odoribacter splanchnicus,...
The noninflamed microenvironment in prostate cancer represents a barrier to immunotherapy. Genetic alterations underlying cell-intrinsic oncogenic signaling are increasingly appreciated for their role shaping the immune landscape. Recently, we identified Pygopus 2 (
A novel 3-layer organic film was fabricated on silicon wafer with a polydopamine coating (coded as PDAc) the interlayer by multistep self-assembly process. The formation and structure of films were analyzed means ellipsometric thickness measurement, water contact angle attenuated total reflection-Fourier transform infrared spectrometry (ATR-FTIR). Meanwhile, an atomic force microscope (AFM) characterization performed to evaluate adhesive microtribological behaviors film, ball-on-plate...
Kupffer cells (KCs) were a significant source of cytokine release during the early stage severe burns. High mobility group box protein 1 (HMGB1) was recently identified as new type proinflammatory cytokine. The ability HMGB1 to generate inflammatory responses after burn trauma has not been well characterized. KCs isolated from sham animals and rats with 30% full-thickness burn, then stimulated increasing concentrations HMGB1. levels Tumor necrosis factor (TNF)-α interleukin (IL)-1β in...
Abstract Background Sepsis is a fatal disease referring to the presence of known or strongly suspected infection coupled with systemic and uncontrolled immune activation causing multiple organ failure. However, current knowledge role lncRNAs in sepsis still extremely limited. Methods We performed an silico investigation gene coexpression pattern for patients response all-cause consecutive intensive care unit (ICU) admissions. modules were identified using WGCNA enrichment analysis....
The vaginal microbiota dysbiosis is closely associated with the development of reproductive diseases. However, contribution mycobiome to intrauterine adhesion (IUA) disease remains unknown. Harnessing 16S and ITS2 rDNA sequencing analysis, we investigate both bacterial fungal compositions across 174 samples taken from cervical canal (CC) middle vagina (MV) sites IUA patients. Overall, there no significant difference in microbial diversity between healthy subjects (HS) observe IUA-specific...
Abstract Background Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a cerebral small vessel disease that carries mutations in NOTCH3 . The clinical manifestations are influenced by genetic environmental factors may include gut microbiome. Results We investigated the fecal metagenome, metabolome, serum neurotransmitters, cytokines cohort of 24 CADASIL patients 28 healthy household controls. integrated-omics study showed harbored an...
Luhuitou fringing reef, which has been seriously affected by human activities and terrestrial runoff, degraded quickly in recent decades. However, direct impact hyperthermal stress probably minimal because of the influence Qiongdong upwelling summer. Seawater temperature anomalies 2010 resulted mean monthly seawater temperatures summer to be 1–2°C higher than same period 3 preceding years. Moderate coral bleaching at reef was observed due high thermal stress. Montipora most susceptible...